| Full name: mitochondrial ribosomal protein L35 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 51318 | HGNC ID: HGNC:14489 | Ensembl Gene: ENSG00000132313 | OMIM ID: 611841 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL35:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL35 | 51318 | 218890_x_at | 0.1576 | 0.7430 | |
| GSE20347 | MRPL35 | 51318 | 218890_x_at | 0.1630 | 0.1424 | |
| GSE23400 | MRPL35 | 51318 | 218890_x_at | 0.3120 | 0.0000 | |
| GSE26886 | MRPL35 | 51318 | 222775_s_at | -0.8415 | 0.0001 | |
| GSE29001 | MRPL35 | 51318 | 218890_x_at | -0.1029 | 0.7701 | |
| GSE38129 | MRPL35 | 51318 | 218890_x_at | 0.2650 | 0.0196 | |
| GSE45670 | MRPL35 | 51318 | 218890_x_at | 0.4495 | 0.0041 | |
| GSE63941 | MRPL35 | 51318 | 218890_x_at | 1.3847 | 0.0006 | |
| GSE77861 | MRPL35 | 51318 | 218890_x_at | 0.0799 | 0.8059 | |
| GSE97050 | MRPL35 | 51318 | A_32_P16489 | -0.2262 | 0.4896 | |
| SRP007169 | MRPL35 | 51318 | RNAseq | 0.2790 | 0.3734 | |
| SRP008496 | MRPL35 | 51318 | RNAseq | 0.0009 | 0.9969 | |
| SRP064894 | MRPL35 | 51318 | RNAseq | 0.1864 | 0.2504 | |
| SRP133303 | MRPL35 | 51318 | RNAseq | 0.3246 | 0.0338 | |
| SRP159526 | MRPL35 | 51318 | RNAseq | 0.1640 | 0.6814 | |
| SRP193095 | MRPL35 | 51318 | RNAseq | -0.3098 | 0.0278 | |
| SRP219564 | MRPL35 | 51318 | RNAseq | 0.0473 | 0.8464 | |
| TCGA | MRPL35 | 51318 | RNAseq | -0.1425 | 0.0034 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL35 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPL35:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL35 | 51318 | 9 | 2 | 19 | |
| GSE20123 | MRPL35 | 51318 | 9 | 2 | 19 | |
| GSE43470 | MRPL35 | 51318 | 4 | 2 | 37 | |
| GSE46452 | MRPL35 | 51318 | 2 | 3 | 54 | |
| GSE47630 | MRPL35 | 51318 | 7 | 0 | 33 | |
| GSE54993 | MRPL35 | 51318 | 0 | 6 | 64 | |
| GSE54994 | MRPL35 | 51318 | 10 | 0 | 43 | |
| GSE60625 | MRPL35 | 51318 | 0 | 3 | 8 | |
| GSE74703 | MRPL35 | 51318 | 4 | 1 | 31 | |
| GSE74704 | MRPL35 | 51318 | 7 | 0 | 13 | |
| TCGA | MRPL35 | 51318 | 35 | 4 | 57 |
Total number of gains: 87; Total number of losses: 23; Total Number of normals: 378.
Somatic mutations of MRPL35:
Generating mutation plots.
Highly correlated genes for MRPL35:
Showing top 20/563 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL35 | ZCCHC10 | 0.786006 | 3 | 0 | 3 |
| MRPL35 | TRAPPC6B | 0.78322 | 3 | 0 | 3 |
| MRPL35 | ELOF1 | 0.774581 | 3 | 0 | 3 |
| MRPL35 | RNF181 | 0.77025 | 5 | 0 | 5 |
| MRPL35 | APPL2 | 0.76781 | 3 | 0 | 3 |
| MRPL35 | PUS7L | 0.754137 | 3 | 0 | 3 |
| MRPL35 | TMTC3 | 0.751989 | 3 | 0 | 3 |
| MRPL35 | NDUFB3 | 0.750553 | 3 | 0 | 3 |
| MRPL35 | SRSF8 | 0.736967 | 3 | 0 | 3 |
| MRPL35 | PPP4R1 | 0.735045 | 3 | 0 | 3 |
| MRPL35 | LAMP2 | 0.734725 | 3 | 0 | 3 |
| MRPL35 | UBE2W | 0.728118 | 3 | 0 | 3 |
| MRPL35 | TMCC3 | 0.727592 | 3 | 0 | 3 |
| MRPL35 | PRELID1 | 0.725877 | 3 | 0 | 3 |
| MRPL35 | CARHSP1 | 0.72566 | 3 | 0 | 3 |
| MRPL35 | SRP68 | 0.72495 | 4 | 0 | 3 |
| MRPL35 | MB21D2 | 0.724355 | 3 | 0 | 3 |
| MRPL35 | IPMK | 0.721138 | 3 | 0 | 3 |
| MRPL35 | NT5DC2 | 0.720091 | 3 | 0 | 3 |
| MRPL35 | DDX52 | 0.719331 | 3 | 0 | 3 |
For details and further investigation, click here
