| Full name: neurofilament heavy | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 4744 | HGNC ID: HGNC:7737 | Ensembl Gene: ENSG00000100285 | OMIM ID: 162230 |
| Drug and gene relationship at DGIdb | |||
NEFH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of NEFH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEFH | 4744 | 204412_s_at | -0.0794 | 0.8648 | |
| GSE20347 | NEFH | 4744 | 204412_s_at | -0.0154 | 0.8280 | |
| GSE23400 | NEFH | 4744 | 204412_s_at | -0.0457 | 0.1012 | |
| GSE26886 | NEFH | 4744 | 204412_s_at | 0.0038 | 0.9871 | |
| GSE29001 | NEFH | 4744 | 204412_s_at | -0.0921 | 0.6570 | |
| GSE38129 | NEFH | 4744 | 204412_s_at | -0.0999 | 0.2308 | |
| GSE45670 | NEFH | 4744 | 204412_s_at | -0.0697 | 0.5320 | |
| GSE53622 | NEFH | 4744 | 19529 | -1.0458 | 0.0000 | |
| GSE53624 | NEFH | 4744 | 19529 | -0.8977 | 0.0000 | |
| GSE63941 | NEFH | 4744 | 204412_s_at | -0.0533 | 0.8851 | |
| GSE77861 | NEFH | 4744 | 204412_s_at | -0.0388 | 0.8173 | |
| GSE97050 | NEFH | 4744 | A_33_P3408152 | -0.5704 | 0.1057 | |
| SRP133303 | NEFH | 4744 | RNAseq | 0.3372 | 0.2730 | |
| SRP219564 | NEFH | 4744 | RNAseq | -0.6382 | 0.4703 | |
| TCGA | NEFH | 4744 | RNAseq | -0.6795 | 0.0317 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NEFH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEFH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEFH | 4744 | 3 | 5 | 22 | |
| GSE20123 | NEFH | 4744 | 3 | 4 | 23 | |
| GSE43470 | NEFH | 4744 | 4 | 5 | 34 | |
| GSE46452 | NEFH | 4744 | 31 | 1 | 27 | |
| GSE47630 | NEFH | 4744 | 8 | 5 | 27 | |
| GSE54993 | NEFH | 4744 | 3 | 6 | 61 | |
| GSE54994 | NEFH | 4744 | 11 | 8 | 34 | |
| GSE60625 | NEFH | 4744 | 5 | 0 | 6 | |
| GSE74703 | NEFH | 4744 | 4 | 4 | 28 | |
| GSE74704 | NEFH | 4744 | 0 | 1 | 19 | |
| TCGA | NEFH | 4744 | 27 | 16 | 53 |
Total number of gains: 99; Total number of losses: 55; Total Number of normals: 334.
Somatic mutations of NEFH:
Generating mutation plots.
Highly correlated genes for NEFH:
Showing top 20/236 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEFH | NKAIN4 | 0.748629 | 3 | 0 | 3 |
| NEFH | ISLR2 | 0.745166 | 3 | 0 | 3 |
| NEFH | RASL10B | 0.736589 | 3 | 0 | 3 |
| NEFH | WNT9A | 0.715751 | 3 | 0 | 3 |
| NEFH | SHISA7 | 0.710931 | 3 | 0 | 3 |
| NEFH | SPRED3 | 0.707082 | 3 | 0 | 3 |
| NEFH | TMEM63A | 0.697405 | 3 | 0 | 3 |
| NEFH | PPP1R12C | 0.692725 | 5 | 0 | 5 |
| NEFH | DCLK1 | 0.673704 | 4 | 0 | 4 |
| NEFH | SP7 | 0.66265 | 3 | 0 | 3 |
| NEFH | ZNF444 | 0.660092 | 4 | 0 | 3 |
| NEFH | C20orf141 | 0.65341 | 4 | 0 | 3 |
| NEFH | FAM181A | 0.653002 | 3 | 0 | 3 |
| NEFH | ZNF575 | 0.646831 | 3 | 0 | 3 |
| NEFH | REG3A | 0.642135 | 4 | 0 | 3 |
| NEFH | HSD3B1 | 0.641132 | 3 | 0 | 3 |
| NEFH | ZNF527 | 0.629928 | 3 | 0 | 3 |
| NEFH | NTNG2 | 0.623823 | 3 | 0 | 3 |
| NEFH | SHANK2-AS3 | 0.623683 | 3 | 0 | 3 |
| NEFH | HAS1 | 0.623556 | 4 | 0 | 3 |
For details and further investigation, click here
