| Full name: hyaluronan synthase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 3036 | HGNC ID: HGNC:4818 | Ensembl Gene: ENSG00000105509 | OMIM ID: 601463 |
| Drug and gene relationship at DGIdb | |||
Expression of HAS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HAS1 | 3036 | 207316_at | -0.1191 | 0.8667 | |
| GSE20347 | HAS1 | 3036 | 207316_at | -0.1494 | 0.0306 | |
| GSE23400 | HAS1 | 3036 | 207316_at | -0.1260 | 0.0369 | |
| GSE26886 | HAS1 | 3036 | 207316_at | 0.1757 | 0.4523 | |
| GSE29001 | HAS1 | 3036 | 207316_at | 0.0413 | 0.9329 | |
| GSE38129 | HAS1 | 3036 | 207316_at | -0.3534 | 0.0285 | |
| GSE45670 | HAS1 | 3036 | 207316_at | -0.0745 | 0.7128 | |
| GSE53622 | HAS1 | 3036 | 21521 | 0.2694 | 0.1586 | |
| GSE53624 | HAS1 | 3036 | 21521 | 0.4862 | 0.0023 | |
| GSE63941 | HAS1 | 3036 | 207316_at | 0.1059 | 0.4971 | |
| GSE77861 | HAS1 | 3036 | 207316_at | -0.1083 | 0.2738 | |
| GSE97050 | HAS1 | 3036 | A_33_P3295203 | 0.0931 | 0.8348 | |
| SRP159526 | HAS1 | 3036 | RNAseq | 0.5858 | 0.5470 | |
| TCGA | HAS1 | 3036 | RNAseq | -1.4051 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HAS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HAS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HAS1 | 3036 | 3 | 4 | 23 | |
| GSE20123 | HAS1 | 3036 | 3 | 3 | 24 | |
| GSE43470 | HAS1 | 3036 | 3 | 12 | 28 | |
| GSE46452 | HAS1 | 3036 | 45 | 1 | 13 | |
| GSE47630 | HAS1 | 3036 | 10 | 6 | 24 | |
| GSE54993 | HAS1 | 3036 | 17 | 4 | 49 | |
| GSE54994 | HAS1 | 3036 | 4 | 14 | 35 | |
| GSE60625 | HAS1 | 3036 | 9 | 0 | 2 | |
| GSE74703 | HAS1 | 3036 | 3 | 8 | 25 | |
| GSE74704 | HAS1 | 3036 | 3 | 1 | 16 | |
| TCGA | HAS1 | 3036 | 14 | 19 | 63 |
Total number of gains: 114; Total number of losses: 72; Total Number of normals: 302.
Somatic mutations of HAS1:
Generating mutation plots.
Highly correlated genes for HAS1:
Showing top 20/266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HAS1 | TGM2 | 0.76299 | 3 | 0 | 3 |
| HAS1 | MYCT1 | 0.720422 | 4 | 0 | 4 |
| HAS1 | SYNE1 | 0.719317 | 3 | 0 | 3 |
| HAS1 | MAP1A | 0.705224 | 4 | 0 | 3 |
| HAS1 | DMRTA1 | 0.700525 | 3 | 0 | 3 |
| HAS1 | SGCG | 0.699674 | 3 | 0 | 3 |
| HAS1 | HSPB7 | 0.69832 | 3 | 0 | 3 |
| HAS1 | PI16 | 0.697585 | 4 | 0 | 4 |
| HAS1 | EBF2 | 0.697579 | 4 | 0 | 3 |
| HAS1 | FAM124A | 0.695338 | 3 | 0 | 3 |
| HAS1 | PARD3B | 0.689358 | 3 | 0 | 3 |
| HAS1 | SLC35D3 | 0.686654 | 3 | 0 | 3 |
| HAS1 | HRH2 | 0.685231 | 4 | 0 | 3 |
| HAS1 | SCARF1 | 0.682818 | 3 | 0 | 3 |
| HAS1 | CADM2 | 0.68111 | 3 | 0 | 3 |
| HAS1 | KCNN3 | 0.680675 | 3 | 0 | 3 |
| HAS1 | MS4A6A | 0.67536 | 3 | 0 | 3 |
| HAS1 | GNA14 | 0.675331 | 3 | 0 | 3 |
| HAS1 | AGTR1 | 0.674792 | 4 | 0 | 4 |
| HAS1 | SOBP | 0.671698 | 3 | 0 | 3 |
For details and further investigation, click here
