| Full name: ELKS/RAB6-interacting/CAST family member 2 | Alias Symbol: CAST|CAST1|KIAA0378|SPBC110|Spc110|ELKSL | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 26059 | HGNC ID: HGNC:31922 | Ensembl Gene: ENSG00000187672 | OMIM ID: 617250 |
| Drug and gene relationship at DGIdb | |||
Expression of ERC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERC2 | 26059 | 213938_at | 1.0233 | 0.1878 | |
| GSE20347 | ERC2 | 26059 | 213938_at | 0.1161 | 0.0847 | |
| GSE23400 | ERC2 | 26059 | 213938_at | 0.0612 | 0.1722 | |
| GSE26886 | ERC2 | 26059 | 213938_at | 0.3901 | 0.0610 | |
| GSE29001 | ERC2 | 26059 | 213938_at | 0.4002 | 0.1523 | |
| GSE38129 | ERC2 | 26059 | 213938_at | 0.3255 | 0.0450 | |
| GSE45670 | ERC2 | 26059 | 213938_at | 0.5600 | 0.0357 | |
| GSE53622 | ERC2 | 26059 | 64915 | 0.4372 | 0.0792 | |
| GSE53624 | ERC2 | 26059 | 64915 | 0.5298 | 0.0005 | |
| GSE63941 | ERC2 | 26059 | 213938_at | 0.1345 | 0.6726 | |
| GSE77861 | ERC2 | 26059 | 213938_at | 0.0294 | 0.7931 | |
| GSE97050 | ERC2 | 26059 | A_24_P374759 | 0.3521 | 0.2110 | |
| SRP133303 | ERC2 | 26059 | RNAseq | 1.4713 | 0.0004 | |
| SRP159526 | ERC2 | 26059 | RNAseq | 2.1174 | 0.0000 | |
| SRP219564 | ERC2 | 26059 | RNAseq | 0.6042 | 0.3102 | |
| TCGA | ERC2 | 26059 | RNAseq | 0.3160 | 0.3499 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ERC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERC2 | 26059 | 0 | 16 | 14 | |
| GSE20123 | ERC2 | 26059 | 0 | 17 | 13 | |
| GSE43470 | ERC2 | 26059 | 0 | 17 | 26 | |
| GSE46452 | ERC2 | 26059 | 2 | 17 | 40 | |
| GSE47630 | ERC2 | 26059 | 1 | 24 | 15 | |
| GSE54993 | ERC2 | 26059 | 6 | 2 | 62 | |
| GSE54994 | ERC2 | 26059 | 0 | 32 | 21 | |
| GSE60625 | ERC2 | 26059 | 5 | 0 | 6 | |
| GSE74703 | ERC2 | 26059 | 0 | 14 | 22 | |
| GSE74704 | ERC2 | 26059 | 0 | 11 | 9 | |
| TCGA | ERC2 | 26059 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 229; Total Number of normals: 245.
Somatic mutations of ERC2:
Generating mutation plots.
Highly correlated genes for ERC2:
Showing top 20/104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERC2 | CA6 | 0.774781 | 3 | 0 | 3 |
| ERC2 | TMEM182 | 0.753319 | 3 | 0 | 3 |
| ERC2 | TMX2 | 0.708357 | 3 | 0 | 3 |
| ERC2 | NGFR | 0.704796 | 4 | 0 | 4 |
| ERC2 | CCDC28B | 0.70392 | 3 | 0 | 3 |
| ERC2 | STPG1 | 0.662448 | 3 | 0 | 3 |
| ERC2 | RANBP1 | 0.659954 | 4 | 0 | 4 |
| ERC2 | NRXN1 | 0.652418 | 3 | 0 | 3 |
| ERC2 | CDC6 | 0.651112 | 4 | 0 | 4 |
| ERC2 | GNB1L | 0.650486 | 4 | 0 | 3 |
| ERC2 | ZNF697 | 0.650269 | 4 | 0 | 3 |
| ERC2 | MED20 | 0.645115 | 3 | 0 | 3 |
| ERC2 | EMID1 | 0.644126 | 3 | 0 | 3 |
| ERC2 | FPR1 | 0.64082 | 3 | 0 | 3 |
| ERC2 | ENTPD6 | 0.635468 | 4 | 0 | 4 |
| ERC2 | ATP7B | 0.634176 | 4 | 0 | 3 |
| ERC2 | CCL26 | 0.626004 | 4 | 0 | 3 |
| ERC2 | UBE2T | 0.625917 | 3 | 0 | 3 |
| ERC2 | DACH1 | 0.621322 | 4 | 0 | 3 |
| ERC2 | CCT7 | 0.620098 | 3 | 0 | 3 |
For details and further investigation, click here
