| Full name: NFKB inhibitor epsilon | Alias Symbol: IKBE | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 4794 | HGNC ID: HGNC:7799 | Ensembl Gene: ENSG00000146232 | OMIM ID: 604548 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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NFKBIE involved pathways:
Expression of NFKBIE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFKBIE | 4794 | 203927_at | 0.7593 | 0.1499 | |
| GSE20347 | NFKBIE | 4794 | 203927_at | 0.5550 | 0.0000 | |
| GSE23400 | NFKBIE | 4794 | 203927_at | 0.3164 | 0.0000 | |
| GSE26886 | NFKBIE | 4794 | 203927_at | 1.4398 | 0.0000 | |
| GSE29001 | NFKBIE | 4794 | 203927_at | 0.3905 | 0.0170 | |
| GSE38129 | NFKBIE | 4794 | 203927_at | 0.5890 | 0.0000 | |
| GSE45670 | NFKBIE | 4794 | 203927_at | 0.4256 | 0.0093 | |
| GSE53622 | NFKBIE | 4794 | 23221 | 0.8671 | 0.0000 | |
| GSE53624 | NFKBIE | 4794 | 23221 | 0.8072 | 0.0000 | |
| GSE63941 | NFKBIE | 4794 | 203927_at | 0.1470 | 0.5510 | |
| GSE77861 | NFKBIE | 4794 | 203927_at | 0.0025 | 0.9887 | |
| GSE97050 | NFKBIE | 4794 | A_23_P30655 | 0.5466 | 0.1978 | |
| SRP007169 | NFKBIE | 4794 | RNAseq | 1.4556 | 0.0093 | |
| SRP008496 | NFKBIE | 4794 | RNAseq | 1.7104 | 0.0002 | |
| SRP064894 | NFKBIE | 4794 | RNAseq | 1.1746 | 0.0000 | |
| SRP133303 | NFKBIE | 4794 | RNAseq | 0.9937 | 0.0000 | |
| SRP159526 | NFKBIE | 4794 | RNAseq | 0.9258 | 0.0777 | |
| SRP193095 | NFKBIE | 4794 | RNAseq | 0.7073 | 0.0001 | |
| SRP219564 | NFKBIE | 4794 | RNAseq | 1.3345 | 0.0135 | |
| TCGA | NFKBIE | 4794 | RNAseq | 0.3167 | 0.0003 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NFKBIE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFKBIE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFKBIE | 4794 | 7 | 1 | 22 | |
| GSE20123 | NFKBIE | 4794 | 7 | 1 | 22 | |
| GSE43470 | NFKBIE | 4794 | 6 | 0 | 37 | |
| GSE46452 | NFKBIE | 4794 | 3 | 9 | 47 | |
| GSE47630 | NFKBIE | 4794 | 8 | 4 | 28 | |
| GSE54993 | NFKBIE | 4794 | 3 | 2 | 65 | |
| GSE54994 | NFKBIE | 4794 | 8 | 3 | 42 | |
| GSE60625 | NFKBIE | 4794 | 0 | 3 | 8 | |
| GSE74703 | NFKBIE | 4794 | 6 | 0 | 30 | |
| GSE74704 | NFKBIE | 4794 | 3 | 1 | 16 | |
| TCGA | NFKBIE | 4794 | 21 | 14 | 61 |
Total number of gains: 72; Total number of losses: 38; Total Number of normals: 378.
Somatic mutations of NFKBIE:
Generating mutation plots.
Highly correlated genes for NFKBIE:
Showing top 20/523 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFKBIE | NOB1 | 0.711302 | 3 | 0 | 3 |
| NFKBIE | CMTM3 | 0.700928 | 4 | 0 | 4 |
| NFKBIE | RELB | 0.684033 | 11 | 0 | 10 |
| NFKBIE | HSCB | 0.680676 | 3 | 0 | 3 |
| NFKBIE | NUDT22 | 0.668358 | 3 | 0 | 3 |
| NFKBIE | GPR84 | 0.665789 | 4 | 0 | 4 |
| NFKBIE | ICAM1 | 0.663524 | 8 | 0 | 6 |
| NFKBIE | BCAT1 | 0.662064 | 5 | 0 | 5 |
| NFKBIE | TAP1 | 0.660518 | 6 | 0 | 6 |
| NFKBIE | CHRNA5 | 0.657627 | 4 | 0 | 4 |
| NFKBIE | MARCKSL1 | 0.656171 | 9 | 0 | 8 |
| NFKBIE | FNDC3B | 0.653295 | 9 | 0 | 9 |
| NFKBIE | SNX10 | 0.650221 | 11 | 0 | 10 |
| NFKBIE | VCAN | 0.647786 | 7 | 0 | 7 |
| NFKBIE | LIN28B | 0.645702 | 4 | 0 | 4 |
| NFKBIE | PMEPA1 | 0.64405 | 9 | 0 | 7 |
| NFKBIE | ADAM8 | 0.64402 | 9 | 0 | 8 |
| NFKBIE | USB1 | 0.641902 | 7 | 0 | 6 |
| NFKBIE | PXDN | 0.640966 | 8 | 0 | 7 |
| NFKBIE | MMP12 | 0.639548 | 10 | 0 | 9 |
For details and further investigation, click here
