| Full name: NK6 homeobox 1 | Alias Symbol: Nkx6.1 | ||
| Type: protein-coding gene | Cytoband: 4q21.23 | ||
| Entrez ID: 4825 | HGNC ID: HGNC:7839 | Ensembl Gene: ENSG00000163623 | OMIM ID: 602563 |
| Drug and gene relationship at DGIdb | |||
NKX6-1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of NKX6-1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKX6-1 | 4825 | 221366_at | -0.4347 | 0.4731 | |
| GSE20347 | NKX6-1 | 4825 | 221366_at | -0.1065 | 0.1130 | |
| GSE23400 | NKX6-1 | 4825 | 221366_at | -0.2530 | 0.0000 | |
| GSE26886 | NKX6-1 | 4825 | 221366_at | -0.0020 | 0.9919 | |
| GSE29001 | NKX6-1 | 4825 | 221366_at | -0.1194 | 0.2239 | |
| GSE38129 | NKX6-1 | 4825 | 221366_at | -0.3498 | 0.0046 | |
| GSE45670 | NKX6-1 | 4825 | 221366_at | -0.1554 | 0.1163 | |
| GSE53622 | NKX6-1 | 4825 | 59400 | -1.4531 | 0.0000 | |
| GSE53624 | NKX6-1 | 4825 | 59400 | -1.2554 | 0.0000 | |
| GSE63941 | NKX6-1 | 4825 | 221366_at | 0.0357 | 0.8613 | |
| GSE77861 | NKX6-1 | 4825 | 221366_at | -0.1732 | 0.0558 | |
| GSE97050 | NKX6-1 | 4825 | A_24_P68991 | -1.3268 | 0.1215 | |
| SRP064894 | NKX6-1 | 4825 | RNAseq | -0.4144 | 0.2973 | |
| SRP133303 | NKX6-1 | 4825 | RNAseq | -1.1072 | 0.0648 | |
| SRP159526 | NKX6-1 | 4825 | RNAseq | -0.4158 | 0.5349 | |
| SRP219564 | NKX6-1 | 4825 | RNAseq | -0.9189 | 0.3927 | |
| TCGA | NKX6-1 | 4825 | RNAseq | -0.2279 | 0.4549 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NKX6-1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKX6-1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKX6-1 | 4825 | 2 | 11 | 17 | |
| GSE20123 | NKX6-1 | 4825 | 2 | 11 | 17 | |
| GSE43470 | NKX6-1 | 4825 | 0 | 13 | 30 | |
| GSE46452 | NKX6-1 | 4825 | 1 | 36 | 22 | |
| GSE47630 | NKX6-1 | 4825 | 0 | 20 | 20 | |
| GSE54993 | NKX6-1 | 4825 | 8 | 0 | 62 | |
| GSE54994 | NKX6-1 | 4825 | 1 | 9 | 43 | |
| GSE60625 | NKX6-1 | 4825 | 0 | 0 | 11 | |
| GSE74703 | NKX6-1 | 4825 | 0 | 11 | 25 | |
| GSE74704 | NKX6-1 | 4825 | 1 | 6 | 13 |
Total number of gains: 15; Total number of losses: 117; Total Number of normals: 260.
Somatic mutations of NKX6-1:
Generating mutation plots.
Highly correlated genes for NKX6-1:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKX6-1 | MRGPRF | 0.844531 | 4 | 0 | 4 |
| NKX6-1 | INMT | 0.816564 | 4 | 0 | 4 |
| NKX6-1 | XKR4 | 0.813228 | 4 | 0 | 4 |
| NKX6-1 | TNFSF12 | 0.807309 | 3 | 0 | 3 |
| NKX6-1 | PI16 | 0.804475 | 4 | 0 | 4 |
| NKX6-1 | CYS1 | 0.80411 | 4 | 0 | 4 |
| NKX6-1 | MYOCD | 0.795422 | 4 | 0 | 4 |
| NKX6-1 | RAB9B | 0.795076 | 4 | 0 | 4 |
| NKX6-1 | SLC35F1 | 0.794792 | 3 | 0 | 3 |
| NKX6-1 | PDK3 | 0.791494 | 3 | 0 | 3 |
| NKX6-1 | FAM83D | 0.789509 | 3 | 0 | 3 |
| NKX6-1 | TTLL11 | 0.781536 | 3 | 0 | 3 |
| NKX6-1 | ZEB1 | 0.77958 | 3 | 0 | 3 |
| NKX6-1 | MAGI2-AS3 | 0.774381 | 3 | 0 | 3 |
| NKX6-1 | LRRN4CL | 0.774342 | 4 | 0 | 4 |
| NKX6-1 | CAMK2G | 0.772677 | 5 | 0 | 5 |
| NKX6-1 | MAMDC2 | 0.771244 | 4 | 0 | 4 |
| NKX6-1 | CYP21A2 | 0.769885 | 3 | 0 | 3 |
| NKX6-1 | TLN1 | 0.767262 | 5 | 0 | 5 |
| NKX6-1 | ZCCHC24 | 0.766644 | 6 | 0 | 6 |
For details and further investigation, click here
