| Full name: nicotinamide nucleotide transhydrogenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5p12 | ||
| Entrez ID: 23530 | HGNC ID: HGNC:7863 | Ensembl Gene: ENSG00000112992 | OMIM ID: 607878 |
| Drug and gene relationship at DGIdb | |||
Expression of NNT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NNT | 23530 | 202783_at | 0.5732 | 0.3228 | |
| GSE20347 | NNT | 23530 | 202783_at | 0.3756 | 0.1314 | |
| GSE23400 | NNT | 23530 | 202784_s_at | 0.5371 | 0.0000 | |
| GSE26886 | NNT | 23530 | 202783_at | -0.0974 | 0.8545 | |
| GSE29001 | NNT | 23530 | 202783_at | 0.2780 | 0.6129 | |
| GSE38129 | NNT | 23530 | 202783_at | 0.2847 | 0.1783 | |
| GSE45670 | NNT | 23530 | 202783_at | 0.0034 | 0.9893 | |
| GSE53622 | NNT | 23530 | 66648 | 0.2384 | 0.0253 | |
| GSE53624 | NNT | 23530 | 66648 | 0.3614 | 0.0002 | |
| GSE63941 | NNT | 23530 | 202783_at | -1.2945 | 0.4332 | |
| GSE77861 | NNT | 23530 | 202783_at | -0.1517 | 0.7722 | |
| GSE97050 | NNT | 23530 | A_23_P70148 | 0.1905 | 0.3810 | |
| SRP007169 | NNT | 23530 | RNAseq | 1.0713 | 0.0424 | |
| SRP008496 | NNT | 23530 | RNAseq | 0.8860 | 0.0074 | |
| SRP064894 | NNT | 23530 | RNAseq | 0.0742 | 0.7003 | |
| SRP133303 | NNT | 23530 | RNAseq | 0.3085 | 0.0506 | |
| SRP159526 | NNT | 23530 | RNAseq | 1.0940 | 0.0292 | |
| SRP193095 | NNT | 23530 | RNAseq | -0.1897 | 0.1142 | |
| SRP219564 | NNT | 23530 | RNAseq | -0.1543 | 0.7203 | |
| TCGA | NNT | 23530 | RNAseq | -0.3795 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NNT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NNT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NNT | 23530 | 10 | 0 | 20 | |
| GSE20123 | NNT | 23530 | 10 | 0 | 20 | |
| GSE43470 | NNT | 23530 | 15 | 0 | 28 | |
| GSE46452 | NNT | 23530 | 5 | 22 | 32 | |
| GSE47630 | NNT | 23530 | 6 | 12 | 22 | |
| GSE54993 | NNT | 23530 | 6 | 3 | 61 | |
| GSE54994 | NNT | 23530 | 24 | 2 | 27 | |
| GSE60625 | NNT | 23530 | 0 | 0 | 11 | |
| GSE74703 | NNT | 23530 | 12 | 0 | 24 | |
| GSE74704 | NNT | 23530 | 9 | 0 | 11 | |
| TCGA | NNT | 23530 | 52 | 6 | 38 |
Total number of gains: 149; Total number of losses: 45; Total Number of normals: 294.
Somatic mutations of NNT:
Generating mutation plots.
Highly correlated genes for NNT:
Showing top 20/629 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NNT | NAB1 | 0.784872 | 3 | 0 | 3 |
| NNT | TMEM205 | 0.778027 | 3 | 0 | 3 |
| NNT | NCOA5 | 0.772846 | 3 | 0 | 3 |
| NNT | IREB2 | 0.758296 | 3 | 0 | 3 |
| NNT | C12orf43 | 0.758161 | 3 | 0 | 3 |
| NNT | EMB | 0.7507 | 3 | 0 | 3 |
| NNT | IFIT5 | 0.747983 | 3 | 0 | 3 |
| NNT | FAM160B1 | 0.739169 | 3 | 0 | 3 |
| NNT | ACP6 | 0.735083 | 3 | 0 | 3 |
| NNT | BRWD1 | 0.73028 | 3 | 0 | 3 |
| NNT | ZNF704 | 0.729156 | 3 | 0 | 3 |
| NNT | SF1 | 0.726641 | 3 | 0 | 3 |
| NNT | ZNF518B | 0.724254 | 3 | 0 | 3 |
| NNT | WTAP | 0.720714 | 3 | 0 | 3 |
| NNT | ZNF354C | 0.720068 | 3 | 0 | 3 |
| NNT | C6orf136 | 0.717023 | 3 | 0 | 3 |
| NNT | TTC4 | 0.713486 | 3 | 0 | 3 |
| NNT | DCHS1 | 0.710611 | 3 | 0 | 3 |
| NNT | PHF8 | 0.708061 | 3 | 0 | 3 |
| NNT | FBXO33 | 0.706319 | 3 | 0 | 3 |
For details and further investigation, click here
