| Full name: bromodomain and WD repeat domain containing 1 | Alias Symbol: FLJ11315|N143|DCAF19 | ||
| Type: protein-coding gene | Cytoband: 21q22.2 | ||
| Entrez ID: 54014 | HGNC ID: HGNC:12760 | Ensembl Gene: ENSG00000185658 | OMIM ID: 617824 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of BRWD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRWD1 | 54014 | 225446_at | 0.2660 | 0.6260 | |
| GSE20347 | BRWD1 | 54014 | 219280_at | -0.0249 | 0.8874 | |
| GSE23400 | BRWD1 | 54014 | 214820_at | -0.2019 | 0.0000 | |
| GSE26886 | BRWD1 | 54014 | 238890_at | -0.3667 | 0.3215 | |
| GSE29001 | BRWD1 | 54014 | 214820_at | -0.4896 | 0.3319 | |
| GSE38129 | BRWD1 | 54014 | 219280_at | 0.0267 | 0.8568 | |
| GSE45670 | BRWD1 | 54014 | 225446_at | -0.3757 | 0.0552 | |
| GSE53622 | BRWD1 | 54014 | 34369 | -0.4111 | 0.0000 | |
| GSE53624 | BRWD1 | 54014 | 34369 | -0.1513 | 0.1080 | |
| GSE63941 | BRWD1 | 54014 | 225446_at | -0.5488 | 0.2165 | |
| GSE77861 | BRWD1 | 54014 | 219280_at | -0.2546 | 0.0220 | |
| GSE97050 | BRWD1 | 54014 | A_24_P190541 | -0.5822 | 0.1421 | |
| SRP007169 | BRWD1 | 54014 | RNAseq | -0.8803 | 0.0079 | |
| SRP008496 | BRWD1 | 54014 | RNAseq | -0.3713 | 0.1571 | |
| SRP064894 | BRWD1 | 54014 | RNAseq | -0.1885 | 0.3409 | |
| SRP133303 | BRWD1 | 54014 | RNAseq | -0.3159 | 0.0189 | |
| SRP159526 | BRWD1 | 54014 | RNAseq | -0.2750 | 0.0560 | |
| SRP193095 | BRWD1 | 54014 | RNAseq | -0.3798 | 0.0000 | |
| SRP219564 | BRWD1 | 54014 | RNAseq | -0.2047 | 0.5306 | |
| TCGA | BRWD1 | 54014 | RNAseq | -0.1341 | 0.0065 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BRWD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRWD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRWD1 | 54014 | 2 | 9 | 19 | |
| GSE20123 | BRWD1 | 54014 | 2 | 10 | 18 | |
| GSE43470 | BRWD1 | 54014 | 0 | 10 | 33 | |
| GSE46452 | BRWD1 | 54014 | 1 | 21 | 37 | |
| GSE47630 | BRWD1 | 54014 | 6 | 17 | 17 | |
| GSE54993 | BRWD1 | 54014 | 8 | 1 | 61 | |
| GSE54994 | BRWD1 | 54014 | 3 | 9 | 41 | |
| GSE60625 | BRWD1 | 54014 | 0 | 0 | 11 | |
| GSE74703 | BRWD1 | 54014 | 0 | 8 | 28 | |
| GSE74704 | BRWD1 | 54014 | 1 | 6 | 13 | |
| TCGA | BRWD1 | 54014 | 8 | 41 | 47 |
Total number of gains: 31; Total number of losses: 132; Total Number of normals: 325.
Somatic mutations of BRWD1:
Generating mutation plots.
Highly correlated genes for BRWD1:
Showing top 20/530 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRWD1 | TMEM167B | 0.805847 | 3 | 0 | 3 |
| BRWD1 | ATG14 | 0.798318 | 3 | 0 | 3 |
| BRWD1 | ZMYM4 | 0.769438 | 3 | 0 | 3 |
| BRWD1 | C2orf76 | 0.769034 | 3 | 0 | 3 |
| BRWD1 | GPBP1 | 0.764865 | 3 | 0 | 3 |
| BRWD1 | PDIK1L | 0.757761 | 3 | 0 | 3 |
| BRWD1 | TADA1 | 0.756235 | 3 | 0 | 3 |
| BRWD1 | BLZF1 | 0.75221 | 4 | 0 | 4 |
| BRWD1 | KIAA1143 | 0.73921 | 3 | 0 | 3 |
| BRWD1 | RAP1GDS1 | 0.738798 | 3 | 0 | 3 |
| BRWD1 | DMTF1 | 0.737714 | 3 | 0 | 3 |
| BRWD1 | ACADM | 0.73254 | 5 | 0 | 5 |
| BRWD1 | UBP1 | 0.731781 | 4 | 0 | 4 |
| BRWD1 | NNT | 0.73028 | 3 | 0 | 3 |
| BRWD1 | STYX | 0.729 | 3 | 0 | 3 |
| BRWD1 | CDC73 | 0.723971 | 4 | 0 | 4 |
| BRWD1 | CCNJ | 0.719842 | 3 | 0 | 3 |
| BRWD1 | LUC7L2 | 0.714726 | 3 | 0 | 3 |
| BRWD1 | ZNF248 | 0.714427 | 3 | 0 | 3 |
| BRWD1 | CCDC90B | 0.714098 | 4 | 0 | 4 |
For details and further investigation, click here
