| Full name: tetratricopeptide repeat domain 4 | Alias Symbol: MGC5097|FLJ41930|CNS1 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 7268 | HGNC ID: HGNC:12394 | Ensembl Gene: ENSG00000243725 | OMIM ID: 606753 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TTC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC4 | 7268 | 218442_at | 0.6061 | 0.0808 | |
| GSE20347 | TTC4 | 7268 | 218442_at | 0.5595 | 0.0031 | |
| GSE23400 | TTC4 | 7268 | 218442_at | 0.2362 | 0.0000 | |
| GSE26886 | TTC4 | 7268 | 218442_at | 0.1137 | 0.6391 | |
| GSE29001 | TTC4 | 7268 | 218442_at | 0.3156 | 0.0503 | |
| GSE38129 | TTC4 | 7268 | 218442_at | 0.6229 | 0.0000 | |
| GSE45670 | TTC4 | 7268 | 218442_at | 0.5156 | 0.0009 | |
| GSE53622 | TTC4 | 7268 | 60057 | 0.5597 | 0.0000 | |
| GSE53624 | TTC4 | 7268 | 60057 | 0.8954 | 0.0000 | |
| GSE63941 | TTC4 | 7268 | 218442_at | 0.4173 | 0.4112 | |
| GSE77861 | TTC4 | 7268 | 218442_at | 0.2567 | 0.1355 | |
| GSE97050 | TTC4 | 7268 | A_23_P230 | 0.3809 | 0.2591 | |
| SRP007169 | TTC4 | 7268 | RNAseq | 0.5909 | 0.1770 | |
| SRP008496 | TTC4 | 7268 | RNAseq | 0.6033 | 0.0124 | |
| SRP064894 | TTC4 | 7268 | RNAseq | 0.5608 | 0.0004 | |
| SRP133303 | TTC4 | 7268 | RNAseq | 0.5724 | 0.0028 | |
| SRP159526 | TTC4 | 7268 | RNAseq | 1.0676 | 0.0516 | |
| SRP193095 | TTC4 | 7268 | RNAseq | 0.4326 | 0.0004 | |
| SRP219564 | TTC4 | 7268 | RNAseq | 0.4379 | 0.2313 | |
| TCGA | TTC4 | 7268 | RNAseq | 0.1760 | 0.0019 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TTC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC4 | 7268 | 3 | 4 | 23 | |
| GSE20123 | TTC4 | 7268 | 3 | 3 | 24 | |
| GSE43470 | TTC4 | 7268 | 7 | 2 | 34 | |
| GSE46452 | TTC4 | 7268 | 2 | 1 | 56 | |
| GSE47630 | TTC4 | 7268 | 8 | 4 | 28 | |
| GSE54993 | TTC4 | 7268 | 0 | 0 | 70 | |
| GSE54994 | TTC4 | 7268 | 10 | 3 | 40 | |
| GSE60625 | TTC4 | 7268 | 0 | 0 | 11 | |
| GSE74703 | TTC4 | 7268 | 5 | 1 | 30 | |
| GSE74704 | TTC4 | 7268 | 2 | 0 | 18 | |
| TCGA | TTC4 | 7268 | 10 | 18 | 68 |
Total number of gains: 50; Total number of losses: 36; Total Number of normals: 402.
Somatic mutations of TTC4:
Generating mutation plots.
Highly correlated genes for TTC4:
Showing top 20/1803 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC4 | SPNS1 | 0.85211 | 3 | 0 | 3 |
| TTC4 | EBNA1BP2 | 0.839484 | 3 | 0 | 3 |
| TTC4 | RPRD1B | 0.810412 | 3 | 0 | 3 |
| TTC4 | PPP5C | 0.792929 | 3 | 0 | 3 |
| TTC4 | ZNF707 | 0.784482 | 3 | 0 | 3 |
| TTC4 | CD47 | 0.753197 | 3 | 0 | 3 |
| TTC4 | TBRG4 | 0.747522 | 4 | 0 | 4 |
| TTC4 | PPIL1 | 0.742397 | 6 | 0 | 6 |
| TTC4 | RRP36 | 0.735645 | 5 | 0 | 5 |
| TTC4 | SNRNP200 | 0.731023 | 3 | 0 | 3 |
| TTC4 | AFAP1L2 | 0.730279 | 3 | 0 | 3 |
| TTC4 | JKAMP | 0.728471 | 6 | 0 | 6 |
| TTC4 | SCNM1 | 0.728341 | 3 | 0 | 3 |
| TTC4 | TMEM189 | 0.725391 | 3 | 0 | 3 |
| TTC4 | XPO6 | 0.72506 | 8 | 0 | 8 |
| TTC4 | TMEM201 | 0.724012 | 4 | 0 | 4 |
| TTC4 | NAA11 | 0.714653 | 3 | 0 | 3 |
| TTC4 | NNT | 0.713486 | 3 | 0 | 3 |
| TTC4 | METTL23 | 0.713165 | 5 | 0 | 4 |
| TTC4 | RDH11 | 0.712657 | 5 | 0 | 5 |
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