NOTCH2

 

Full name: notch receptor 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p12
Entrez ID: 4853 HGNC ID: HGNC:7882 Ensembl Gene: ENSG00000134250 OMIM ID: 600275
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

NOTCH2 involved pathways:

KEGG pathway Description View
hsa04330Notch signaling pathway
hsa04919Thyroid hormone signaling pathway

 

Expression of NOTCH2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NOTCH2 4853 202443_x_at -0.3531 0.5067
GSE20347 NOTCH2 4853 202443_x_at -1.0194 0.0000
GSE23400 NOTCH2 4853 202443_x_at -0.5768 0.0000
GSE26886 NOTCH2 4853 202443_x_at -0.9626 0.0000
GSE29001 NOTCH2 4853 202443_x_at -0.6825 0.0946
GSE38129 NOTCH2 4853 202443_x_at -0.8113 0.0000
GSE45670 NOTCH2 4853 202443_x_at -0.2533 0.1170
GSE53622 NOTCH2 4853 14813 -0.7108 0.0000
GSE53624 NOTCH2 4853 14813 -0.8513 0.0000
GSE63941 NOTCH2 4853 202443_x_at -0.9756 0.1483
GSE77861 NOTCH2 4853 202443_x_at -0.7412 0.1315
GSE97050 NOTCH2 4853 A_33_P3258824 -0.3864 0.1367
SRP007169 NOTCH2 4853 RNAseq -0.0574 0.9028
SRP008496 NOTCH2 4853 RNAseq -0.2647 0.4417
SRP064894 NOTCH2 4853 RNAseq -0.3841 0.0789
SRP133303 NOTCH2 4853 RNAseq -0.5957 0.0000
SRP159526 NOTCH2 4853 RNAseq -1.0193 0.0000
SRP193095 NOTCH2 4853 RNAseq -0.2581 0.2573
SRP219564 NOTCH2 4853 RNAseq -0.3125 0.3335
TCGA NOTCH2 4853 RNAseq -0.0435 0.4683

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by NOTCH2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NOTCH2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NOTCH2 4853 3 5 22
GSE20123 NOTCH2 4853 4 5 21
GSE43470 NOTCH2 4853 1 3 39
GSE46452 NOTCH2 4853 2 1 56
GSE47630 NOTCH2 4853 11 3 26
GSE54993 NOTCH2 4853 0 2 68
GSE54994 NOTCH2 4853 12 0 41
GSE60625 NOTCH2 4853 0 0 11
GSE74703 NOTCH2 4853 1 3 32
GSE74704 NOTCH2 4853 2 3 15
TCGA NOTCH2 4853 34 16 46

Total number of gains: 70; Total number of losses: 41; Total Number of normals: 377.  

 

Somatic mutations of NOTCH2:

 

Generating mutation plots.

 

Highly correlated genes for NOTCH2:

 

Showing top 20/1408 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NOTCH2MRPS18A0.820277303
NOTCH2GALNT110.792952303
NOTCH2ZNF8290.784065303
NOTCH2NOA10.779658303
NOTCH2PPP2R5E0.769426303
NOTCH2TMEM2180.766474303
NOTCH2ZFP820.763348303
NOTCH2MACROD20.758375303
NOTCH2ESYT20.757211303
NOTCH2AQR0.756328303
NOTCH2HDHD20.74861505
NOTCH2KIAA20260.747431403
NOTCH2WWP10.744286303
NOTCH2OS90.743172404
NOTCH2NBPF110.741464303
NOTCH2DDI20.739142303
NOTCH2SRP680.735407303
NOTCH2TRIM220.731643303
NOTCH2ZNF3470.731454404
NOTCH2SNX170.726692303

For details and further investigation, click here