| Full name: mitochondrial ribosomal protein S18A | Alias Symbol: FLJ10548|MRPS18-3 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 55168 | HGNC ID: HGNC:14515 | Ensembl Gene: ENSG00000096080 | OMIM ID: 611981 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPS18A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS18A | 55168 | 221693_s_at | -0.1278 | 0.8291 | |
| GSE20347 | MRPS18A | 55168 | 218385_at | -0.2216 | 0.0210 | |
| GSE23400 | MRPS18A | 55168 | 221693_s_at | -0.1665 | 0.0013 | |
| GSE26886 | MRPS18A | 55168 | 218385_at | 0.1453 | 0.5250 | |
| GSE29001 | MRPS18A | 55168 | 218385_at | -0.4516 | 0.0376 | |
| GSE38129 | MRPS18A | 55168 | 221693_s_at | -0.2766 | 0.1104 | |
| GSE45670 | MRPS18A | 55168 | 221693_s_at | 0.0312 | 0.8423 | |
| GSE63941 | MRPS18A | 55168 | 221693_s_at | 0.5740 | 0.1106 | |
| GSE77861 | MRPS18A | 55168 | 221693_s_at | -0.3930 | 0.1754 | |
| GSE97050 | MRPS18A | 55168 | A_23_P122387 | 0.1133 | 0.6898 | |
| SRP007169 | MRPS18A | 55168 | RNAseq | -1.3045 | 0.0003 | |
| SRP008496 | MRPS18A | 55168 | RNAseq | -1.1442 | 0.0000 | |
| SRP064894 | MRPS18A | 55168 | RNAseq | -0.2721 | 0.3204 | |
| SRP133303 | MRPS18A | 55168 | RNAseq | -0.0843 | 0.5852 | |
| SRP159526 | MRPS18A | 55168 | RNAseq | -0.3159 | 0.1594 | |
| SRP193095 | MRPS18A | 55168 | RNAseq | -0.5434 | 0.0000 | |
| SRP219564 | MRPS18A | 55168 | RNAseq | -0.2567 | 0.3834 | |
| TCGA | MRPS18A | 55168 | RNAseq | -0.0796 | 0.1938 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MRPS18A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRPS18A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS18A | 55168 | 7 | 0 | 23 | |
| GSE20123 | MRPS18A | 55168 | 7 | 0 | 23 | |
| GSE43470 | MRPS18A | 55168 | 6 | 0 | 37 | |
| GSE46452 | MRPS18A | 55168 | 2 | 9 | 48 | |
| GSE47630 | MRPS18A | 55168 | 8 | 4 | 28 | |
| GSE54993 | MRPS18A | 55168 | 3 | 2 | 65 | |
| GSE54994 | MRPS18A | 55168 | 10 | 4 | 39 | |
| GSE60625 | MRPS18A | 55168 | 0 | 1 | 10 | |
| GSE74703 | MRPS18A | 55168 | 6 | 0 | 30 | |
| GSE74704 | MRPS18A | 55168 | 3 | 0 | 17 | |
| TCGA | MRPS18A | 55168 | 22 | 11 | 63 |
Total number of gains: 74; Total number of losses: 31; Total Number of normals: 383.
Somatic mutations of MRPS18A:
Generating mutation plots.
Highly correlated genes for MRPS18A:
Showing top 20/327 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS18A | DCAF10 | 0.841806 | 3 | 0 | 3 |
| MRPS18A | NOTCH2 | 0.820277 | 3 | 0 | 3 |
| MRPS18A | GDE1 | 0.780462 | 3 | 0 | 3 |
| MRPS18A | FBXW9 | 0.780136 | 3 | 0 | 3 |
| MRPS18A | ZACN | 0.77838 | 3 | 0 | 3 |
| MRPS18A | ZKSCAN4 | 0.777581 | 3 | 0 | 3 |
| MRPS18A | ERCC6 | 0.772986 | 3 | 0 | 3 |
| MRPS18A | CHCHD1 | 0.77261 | 3 | 0 | 3 |
| MRPS18A | ZNF616 | 0.771399 | 3 | 0 | 3 |
| MRPS18A | MRPL1 | 0.752644 | 3 | 0 | 3 |
| MRPS18A | ZMPSTE24 | 0.752522 | 3 | 0 | 3 |
| MRPS18A | MCOLN1 | 0.748895 | 3 | 0 | 3 |
| MRPS18A | USP3 | 0.74615 | 3 | 0 | 3 |
| MRPS18A | UBA52 | 0.737776 | 4 | 0 | 4 |
| MRPS18A | STUB1 | 0.728099 | 3 | 0 | 3 |
| MRPS18A | CELA3A | 0.727922 | 3 | 0 | 3 |
| MRPS18A | HACL1 | 0.72716 | 3 | 0 | 3 |
| MRPS18A | NKAPL | 0.72669 | 3 | 0 | 3 |
| MRPS18A | SDHB | 0.726363 | 4 | 0 | 4 |
| MRPS18A | FAHD1 | 0.725389 | 3 | 0 | 3 |
For details and further investigation, click here
