| Full name: signal recognition particle 68 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 6730 | HGNC ID: HGNC:11302 | Ensembl Gene: ENSG00000167881 | OMIM ID: 604858 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SRP68:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRP68 | 6730 | 224607_s_at | -0.1237 | 0.8060 | |
| GSE26886 | SRP68 | 6730 | 224607_s_at | -0.5084 | 0.0006 | |
| GSE45670 | SRP68 | 6730 | 224607_s_at | -0.0328 | 0.8553 | |
| GSE53622 | SRP68 | 6730 | 37227 | -0.0306 | 0.6567 | |
| GSE53624 | SRP68 | 6730 | 37227 | -0.2639 | 0.0000 | |
| GSE63941 | SRP68 | 6730 | 224607_s_at | 1.1202 | 0.0009 | |
| GSE77861 | SRP68 | 6730 | 224607_s_at | -0.0412 | 0.8683 | |
| GSE97050 | SRP68 | 6730 | A_23_P118353 | -0.0544 | 0.8241 | |
| SRP007169 | SRP68 | 6730 | RNAseq | -0.4849 | 0.2077 | |
| SRP008496 | SRP68 | 6730 | RNAseq | -0.5548 | 0.0493 | |
| SRP064894 | SRP68 | 6730 | RNAseq | -0.1186 | 0.4481 | |
| SRP133303 | SRP68 | 6730 | RNAseq | 0.2803 | 0.1923 | |
| SRP159526 | SRP68 | 6730 | RNAseq | -0.2792 | 0.1179 | |
| SRP193095 | SRP68 | 6730 | RNAseq | -0.3617 | 0.0031 | |
| SRP219564 | SRP68 | 6730 | RNAseq | -0.3637 | 0.2344 | |
| TCGA | SRP68 | 6730 | RNAseq | 0.0523 | 0.2467 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SRP68 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRP68:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRP68 | 6730 | 7 | 2 | 21 | |
| GSE20123 | SRP68 | 6730 | 7 | 2 | 21 | |
| GSE43470 | SRP68 | 6730 | 5 | 3 | 35 | |
| GSE46452 | SRP68 | 6730 | 34 | 0 | 25 | |
| GSE47630 | SRP68 | 6730 | 8 | 1 | 31 | |
| GSE54993 | SRP68 | 6730 | 2 | 5 | 63 | |
| GSE54994 | SRP68 | 6730 | 10 | 4 | 39 | |
| GSE60625 | SRP68 | 6730 | 6 | 0 | 5 | |
| GSE74703 | SRP68 | 6730 | 5 | 1 | 30 | |
| GSE74704 | SRP68 | 6730 | 5 | 1 | 14 | |
| TCGA | SRP68 | 6730 | 31 | 10 | 55 |
Total number of gains: 120; Total number of losses: 29; Total Number of normals: 339.
Somatic mutations of SRP68:
Generating mutation plots.
Highly correlated genes for SRP68:
Showing top 20/474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRP68 | SRRM1 | 0.85858 | 3 | 0 | 3 |
| SRP68 | CCDC6 | 0.833743 | 3 | 0 | 3 |
| SRP68 | TJP1 | 0.831424 | 3 | 0 | 3 |
| SRP68 | PRDM2 | 0.814203 | 3 | 0 | 3 |
| SRP68 | PITHD1 | 0.810249 | 4 | 0 | 4 |
| SRP68 | PTGES3 | 0.800797 | 3 | 0 | 3 |
| SRP68 | FAM114A2 | 0.779937 | 3 | 0 | 3 |
| SRP68 | TMEM205 | 0.779506 | 3 | 0 | 3 |
| SRP68 | E2F4 | 0.77871 | 3 | 0 | 3 |
| SRP68 | VPS26A | 0.769192 | 4 | 0 | 4 |
| SRP68 | CHMP2A | 0.745667 | 3 | 0 | 3 |
| SRP68 | UPF3B | 0.745447 | 3 | 0 | 3 |
| SRP68 | TRAPPC8 | 0.744161 | 3 | 0 | 3 |
| SRP68 | GLUD1 | 0.7406 | 3 | 0 | 3 |
| SRP68 | MUC20 | 0.740458 | 3 | 0 | 3 |
| SRP68 | UGP2 | 0.73924 | 3 | 0 | 3 |
| SRP68 | PLXNA2 | 0.737835 | 3 | 0 | 3 |
| SRP68 | ALG10 | 0.737567 | 3 | 0 | 3 |
| SRP68 | ZDHHC6 | 0.737543 | 3 | 0 | 3 |
| SRP68 | NOTCH2 | 0.735407 | 3 | 0 | 3 |
For details and further investigation, click here
