| Full name: WW domain containing E3 ubiquitin protein ligase 1 | Alias Symbol: AIP5|DKFZP434D2111 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 11059 | HGNC ID: HGNC:17004 | Ensembl Gene: ENSG00000123124 | OMIM ID: 602307 |
| Drug and gene relationship at DGIdb | |||
Expression of WWP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WWP1 | 11059 | 212638_s_at | 0.1017 | 0.7761 | |
| GSE20347 | WWP1 | 11059 | 212638_s_at | 0.0889 | 0.6528 | |
| GSE23400 | WWP1 | 11059 | 212638_s_at | 0.0322 | 0.7455 | |
| GSE26886 | WWP1 | 11059 | 212638_s_at | -0.9786 | 0.0004 | |
| GSE29001 | WWP1 | 11059 | 212638_s_at | 0.0495 | 0.9020 | |
| GSE38129 | WWP1 | 11059 | 212638_s_at | -0.0735 | 0.8034 | |
| GSE45670 | WWP1 | 11059 | 212638_s_at | -0.3145 | 0.0157 | |
| GSE53622 | WWP1 | 11059 | 69677 | -0.3055 | 0.0000 | |
| GSE53624 | WWP1 | 11059 | 69677 | -0.2221 | 0.0000 | |
| GSE63941 | WWP1 | 11059 | 212638_s_at | 0.0967 | 0.8493 | |
| GSE77861 | WWP1 | 11059 | 212638_s_at | 0.2686 | 0.3693 | |
| GSE97050 | WWP1 | 11059 | A_23_P146990 | -0.2046 | 0.4368 | |
| SRP007169 | WWP1 | 11059 | RNAseq | -0.2367 | 0.4744 | |
| SRP008496 | WWP1 | 11059 | RNAseq | -0.1231 | 0.5000 | |
| SRP064894 | WWP1 | 11059 | RNAseq | -0.0957 | 0.6200 | |
| SRP133303 | WWP1 | 11059 | RNAseq | -0.1612 | 0.3365 | |
| SRP159526 | WWP1 | 11059 | RNAseq | -0.2387 | 0.5178 | |
| SRP193095 | WWP1 | 11059 | RNAseq | -0.0944 | 0.4567 | |
| SRP219564 | WWP1 | 11059 | RNAseq | -0.4909 | 0.0086 | |
| TCGA | WWP1 | 11059 | RNAseq | -0.1556 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WWP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WWP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WWP1 | 11059 | 14 | 1 | 15 | |
| GSE20123 | WWP1 | 11059 | 16 | 1 | 13 | |
| GSE43470 | WWP1 | 11059 | 19 | 1 | 23 | |
| GSE46452 | WWP1 | 11059 | 21 | 0 | 38 | |
| GSE47630 | WWP1 | 11059 | 23 | 0 | 17 | |
| GSE54993 | WWP1 | 11059 | 0 | 20 | 50 | |
| GSE54994 | WWP1 | 11059 | 32 | 1 | 20 | |
| GSE60625 | WWP1 | 11059 | 0 | 4 | 7 | |
| GSE74703 | WWP1 | 11059 | 16 | 1 | 19 | |
| GSE74704 | WWP1 | 11059 | 10 | 0 | 10 | |
| TCGA | WWP1 | 11059 | 54 | 2 | 40 |
Total number of gains: 205; Total number of losses: 31; Total Number of normals: 252.
Somatic mutations of WWP1:
Generating mutation plots.
Highly correlated genes for WWP1:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WWP1 | METTL14 | 0.863721 | 3 | 0 | 3 |
| WWP1 | NBEAL1 | 0.842707 | 3 | 0 | 3 |
| WWP1 | MRFAP1 | 0.814353 | 3 | 0 | 3 |
| WWP1 | LYSMD1 | 0.808719 | 3 | 0 | 3 |
| WWP1 | ZNF567 | 0.807301 | 3 | 0 | 3 |
| WWP1 | ZNF7 | 0.791211 | 3 | 0 | 3 |
| WWP1 | TMEM181 | 0.788722 | 4 | 0 | 4 |
| WWP1 | MYLIP | 0.788535 | 3 | 0 | 3 |
| WWP1 | ZSCAN29 | 0.788385 | 3 | 0 | 3 |
| WWP1 | EXOC8 | 0.784195 | 3 | 0 | 3 |
| WWP1 | TADA1 | 0.780855 | 3 | 0 | 3 |
| WWP1 | CBX5 | 0.773642 | 3 | 0 | 3 |
| WWP1 | IMPACT | 0.770122 | 3 | 0 | 3 |
| WWP1 | AP1AR | 0.764076 | 3 | 0 | 3 |
| WWP1 | CRNKL1 | 0.763192 | 3 | 0 | 3 |
| WWP1 | PTGES3 | 0.759115 | 3 | 0 | 3 |
| WWP1 | UCHL5 | 0.759054 | 3 | 0 | 3 |
| WWP1 | NUFIP2 | 0.758557 | 4 | 0 | 4 |
| WWP1 | ZNF566 | 0.756388 | 4 | 0 | 4 |
| WWP1 | ZNF397 | 0.756351 | 4 | 0 | 4 |
For details and further investigation, click here
