| Full name: retinoid X receptor beta | Alias Symbol: NR2B2|H-2RIIBP|RCoR-1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 6257 | HGNC ID: HGNC:10478 | Ensembl Gene: ENSG00000204231 | OMIM ID: 180246 |
| Drug and gene relationship at DGIdb | |||
RXRB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer | |
| hsa05223 | Non-small cell lung cancer |
Expression of RXRB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RXRB | 6257 | 209148_at | 0.0966 | 0.8835 | |
| GSE20347 | RXRB | 6257 | 209148_at | 0.0103 | 0.9186 | |
| GSE23400 | RXRB | 6257 | 209148_at | 0.0095 | 0.8226 | |
| GSE26886 | RXRB | 6257 | 209148_at | -0.3341 | 0.0118 | |
| GSE29001 | RXRB | 6257 | 209148_at | -0.0424 | 0.8638 | |
| GSE38129 | RXRB | 6257 | 209148_at | -0.0316 | 0.6834 | |
| GSE45670 | RXRB | 6257 | 209148_at | -0.0594 | 0.6430 | |
| GSE53622 | RXRB | 6257 | 44296 | 0.0477 | 0.4246 | |
| GSE53624 | RXRB | 6257 | 44296 | -0.0972 | 0.1559 | |
| GSE63941 | RXRB | 6257 | 209148_at | -0.1729 | 0.3140 | |
| GSE77861 | RXRB | 6257 | 209148_at | -0.1407 | 0.4007 | |
| GSE97050 | RXRB | 6257 | A_23_P59179 | 0.0549 | 0.7798 | |
| SRP007169 | RXRB | 6257 | RNAseq | -0.3754 | 0.3221 | |
| SRP008496 | RXRB | 6257 | RNAseq | -0.4244 | 0.0322 | |
| SRP064894 | RXRB | 6257 | RNAseq | 0.0507 | 0.6919 | |
| SRP133303 | RXRB | 6257 | RNAseq | -0.3311 | 0.0220 | |
| SRP159526 | RXRB | 6257 | RNAseq | 0.0822 | 0.7937 | |
| SRP193095 | RXRB | 6257 | RNAseq | -0.0157 | 0.8771 | |
| SRP219564 | RXRB | 6257 | RNAseq | -0.0418 | 0.8834 | |
| TCGA | RXRB | 6257 | RNAseq | -0.0967 | 0.0527 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RXRB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RXRB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RXRB | 6257 | 5 | 0 | 25 | |
| GSE20123 | RXRB | 6257 | 5 | 0 | 25 | |
| GSE43470 | RXRB | 6257 | 4 | 1 | 38 | |
| GSE46452 | RXRB | 6257 | 2 | 9 | 48 | |
| GSE47630 | RXRB | 6257 | 8 | 4 | 28 | |
| GSE54993 | RXRB | 6257 | 3 | 1 | 66 | |
| GSE54994 | RXRB | 6257 | 11 | 4 | 38 | |
| GSE60625 | RXRB | 6257 | 1 | 0 | 10 | |
| GSE74703 | RXRB | 6257 | 4 | 0 | 32 | |
| GSE74704 | RXRB | 6257 | 2 | 0 | 18 | |
| TCGA | RXRB | 6257 | 15 | 16 | 65 |
Total number of gains: 60; Total number of losses: 35; Total Number of normals: 393.
Somatic mutations of RXRB:
Generating mutation plots.
Highly correlated genes for RXRB:
Showing top 20/55 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RXRB | GRIPAP1 | 0.76268 | 3 | 0 | 3 |
| RXRB | ZSCAN9 | 0.725107 | 3 | 0 | 3 |
| RXRB | TULP1 | 0.715611 | 3 | 0 | 3 |
| RXRB | NUDT16L1 | 0.694364 | 3 | 0 | 3 |
| RXRB | LRCH4 | 0.680777 | 3 | 0 | 3 |
| RXRB | SYNGAP1 | 0.670731 | 3 | 0 | 3 |
| RXRB | LMAN1L | 0.667689 | 3 | 0 | 3 |
| RXRB | CYB561D1 | 0.660889 | 3 | 0 | 3 |
| RXRB | RIPK4 | 0.656004 | 3 | 0 | 3 |
| RXRB | BTBD9 | 0.654164 | 4 | 0 | 3 |
| RXRB | CLN3 | 0.647243 | 4 | 0 | 3 |
| RXRB | PHYHIP | 0.644724 | 3 | 0 | 3 |
| RXRB | CCNL2 | 0.638728 | 4 | 0 | 3 |
| RXRB | MBP | 0.619429 | 3 | 0 | 3 |
| RXRB | ZNF576 | 0.61737 | 4 | 0 | 3 |
| RXRB | MOB2 | 0.617339 | 4 | 0 | 4 |
| RXRB | PGBD2 | 0.615824 | 4 | 0 | 3 |
| RXRB | BAZ2A | 0.615273 | 4 | 0 | 3 |
| RXRB | JADE3 | 0.613774 | 3 | 0 | 3 |
| RXRB | TINCR | 0.609728 | 3 | 0 | 3 |
For details and further investigation, click here
