| Full name: nuclear mitotic apparatus protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 4926 | HGNC ID: HGNC:8059 | Ensembl Gene: ENSG00000137497 | OMIM ID: 164009 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NUMA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUMA1 | 4926 | 200747_s_at | 0.3330 | 0.5030 | |
| GSE20347 | NUMA1 | 4926 | 200747_s_at | -0.2236 | 0.2862 | |
| GSE23400 | NUMA1 | 4926 | 200747_s_at | -0.0430 | 0.6469 | |
| GSE26886 | NUMA1 | 4926 | 200747_s_at | 0.2489 | 0.2918 | |
| GSE29001 | NUMA1 | 4926 | 200747_s_at | -0.5858 | 0.0329 | |
| GSE38129 | NUMA1 | 4926 | 200747_s_at | -0.3025 | 0.0642 | |
| GSE45670 | NUMA1 | 4926 | 200747_s_at | -0.1711 | 0.3005 | |
| GSE53622 | NUMA1 | 4926 | 79001 | -0.2284 | 0.0199 | |
| GSE53624 | NUMA1 | 4926 | 79001 | -0.0507 | 0.5827 | |
| GSE63941 | NUMA1 | 4926 | 200747_s_at | 0.2087 | 0.7495 | |
| GSE77861 | NUMA1 | 4926 | 200747_s_at | -0.1829 | 0.4572 | |
| GSE97050 | NUMA1 | 4926 | A_23_P162120 | 0.3298 | 0.4977 | |
| SRP007169 | NUMA1 | 4926 | RNAseq | -0.2229 | 0.5425 | |
| SRP008496 | NUMA1 | 4926 | RNAseq | -0.0460 | 0.8582 | |
| SRP064894 | NUMA1 | 4926 | RNAseq | -0.1978 | 0.3666 | |
| SRP133303 | NUMA1 | 4926 | RNAseq | 0.2159 | 0.5031 | |
| SRP159526 | NUMA1 | 4926 | RNAseq | -0.9376 | 0.0001 | |
| SRP193095 | NUMA1 | 4926 | RNAseq | -0.4023 | 0.0082 | |
| SRP219564 | NUMA1 | 4926 | RNAseq | 0.1198 | 0.7359 | |
| TCGA | NUMA1 | 4926 | RNAseq | -0.0508 | 0.3246 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NUMA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUMA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUMA1 | 4926 | 10 | 7 | 13 | |
| GSE20123 | NUMA1 | 4926 | 10 | 7 | 13 | |
| GSE43470 | NUMA1 | 4926 | 9 | 4 | 30 | |
| GSE46452 | NUMA1 | 4926 | 13 | 16 | 30 | |
| GSE47630 | NUMA1 | 4926 | 10 | 10 | 20 | |
| GSE54993 | NUMA1 | 4926 | 7 | 3 | 60 | |
| GSE54994 | NUMA1 | 4926 | 14 | 11 | 28 | |
| GSE60625 | NUMA1 | 4926 | 0 | 7 | 4 | |
| GSE74703 | NUMA1 | 4926 | 7 | 3 | 26 | |
| GSE74704 | NUMA1 | 4926 | 7 | 4 | 9 | |
| TCGA | NUMA1 | 4926 | 36 | 20 | 40 |
Total number of gains: 123; Total number of losses: 92; Total Number of normals: 273.
Somatic mutations of NUMA1:
Generating mutation plots.
Highly correlated genes for NUMA1:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUMA1 | FSIP2 | 0.758635 | 3 | 0 | 3 |
| NUMA1 | SCFD2 | 0.754763 | 3 | 0 | 3 |
| NUMA1 | TYSND1 | 0.748847 | 3 | 0 | 3 |
| NUMA1 | SLC25A10 | 0.744905 | 3 | 0 | 3 |
| NUMA1 | FAM111A | 0.73769 | 3 | 0 | 3 |
| NUMA1 | LAMTOR1 | 0.717588 | 7 | 0 | 7 |
| NUMA1 | PTPRU | 0.716544 | 3 | 0 | 3 |
| NUMA1 | MFSD5 | 0.71015 | 3 | 0 | 3 |
| NUMA1 | E2F4 | 0.709186 | 3 | 0 | 3 |
| NUMA1 | UNC119 | 0.707064 | 3 | 0 | 3 |
| NUMA1 | SLC35D3 | 0.700256 | 3 | 0 | 3 |
| NUMA1 | GTF3C1 | 0.691316 | 4 | 0 | 3 |
| NUMA1 | ZNF597 | 0.689529 | 3 | 0 | 3 |
| NUMA1 | ZNF792 | 0.684399 | 3 | 0 | 3 |
| NUMA1 | LRTOMT | 0.678326 | 7 | 0 | 6 |
| NUMA1 | ZCCHC3 | 0.677475 | 3 | 0 | 3 |
| NUMA1 | EPHB6 | 0.675539 | 3 | 0 | 3 |
| NUMA1 | C2CD2L | 0.670272 | 3 | 0 | 3 |
| NUMA1 | RHBDF1 | 0.668051 | 4 | 0 | 3 |
| NUMA1 | ZNF747 | 0.666968 | 3 | 0 | 3 |
For details and further investigation, click here
