| Full name: general transcription factor IIIC subunit 1 | Alias Symbol: TFIIIC220 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 2975 | HGNC ID: HGNC:4664 | Ensembl Gene: ENSG00000077235 | OMIM ID: 603246 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of GTF3C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF3C1 | 2975 | 35671_at | -0.3616 | 0.4764 | |
| GSE20347 | GTF3C1 | 2975 | 35671_at | -0.7435 | 0.0000 | |
| GSE23400 | GTF3C1 | 2975 | 35671_at | -0.4339 | 0.0000 | |
| GSE26886 | GTF3C1 | 2975 | 35671_at | -0.7162 | 0.0005 | |
| GSE29001 | GTF3C1 | 2975 | 35671_at | -0.6385 | 0.0014 | |
| GSE38129 | GTF3C1 | 2975 | 35671_at | -0.4805 | 0.0001 | |
| GSE45670 | GTF3C1 | 2975 | 35671_at | -0.2604 | 0.1290 | |
| GSE53622 | GTF3C1 | 2975 | 115582 | -0.6905 | 0.0000 | |
| GSE53624 | GTF3C1 | 2975 | 115582 | -0.5722 | 0.0000 | |
| GSE63941 | GTF3C1 | 2975 | 35671_at | 0.1855 | 0.4628 | |
| GSE77861 | GTF3C1 | 2975 | 35671_at | -0.3813 | 0.1910 | |
| GSE97050 | GTF3C1 | 2975 | A_23_P152344 | -0.0228 | 0.9338 | |
| SRP007169 | GTF3C1 | 2975 | RNAseq | -0.3308 | 0.3799 | |
| SRP008496 | GTF3C1 | 2975 | RNAseq | -0.3908 | 0.1704 | |
| SRP064894 | GTF3C1 | 2975 | RNAseq | -1.1238 | 0.0000 | |
| SRP133303 | GTF3C1 | 2975 | RNAseq | -0.7127 | 0.0000 | |
| SRP159526 | GTF3C1 | 2975 | RNAseq | -0.7921 | 0.0016 | |
| SRP193095 | GTF3C1 | 2975 | RNAseq | -0.7711 | 0.0000 | |
| SRP219564 | GTF3C1 | 2975 | RNAseq | -0.9971 | 0.0073 | |
| TCGA | GTF3C1 | 2975 | RNAseq | -0.0430 | 0.3412 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GTF3C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF3C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF3C1 | 2975 | 3 | 5 | 22 | |
| GSE20123 | GTF3C1 | 2975 | 3 | 4 | 23 | |
| GSE43470 | GTF3C1 | 2975 | 4 | 3 | 36 | |
| GSE46452 | GTF3C1 | 2975 | 38 | 1 | 20 | |
| GSE47630 | GTF3C1 | 2975 | 11 | 7 | 22 | |
| GSE54993 | GTF3C1 | 2975 | 3 | 5 | 62 | |
| GSE54994 | GTF3C1 | 2975 | 4 | 9 | 40 | |
| GSE60625 | GTF3C1 | 2975 | 4 | 0 | 7 | |
| GSE74703 | GTF3C1 | 2975 | 4 | 2 | 30 | |
| GSE74704 | GTF3C1 | 2975 | 2 | 2 | 16 | |
| TCGA | GTF3C1 | 2975 | 19 | 12 | 65 |
Total number of gains: 95; Total number of losses: 50; Total Number of normals: 343.
Somatic mutations of GTF3C1:
Generating mutation plots.
Highly correlated genes for GTF3C1:
Showing top 20/1551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF3C1 | EVPL | 0.820751 | 10 | 0 | 10 |
| GTF3C1 | PLEKHM1 | 0.787063 | 12 | 0 | 11 |
| GTF3C1 | TOM1 | 0.773972 | 12 | 0 | 11 |
| GTF3C1 | GLTP | 0.773784 | 9 | 0 | 9 |
| GTF3C1 | GDPD3 | 0.770185 | 10 | 0 | 10 |
| GTF3C1 | VPS25 | 0.769348 | 6 | 0 | 6 |
| GTF3C1 | CYSRT1 | 0.766849 | 6 | 0 | 6 |
| GTF3C1 | SCNN1B | 0.761135 | 10 | 0 | 10 |
| GTF3C1 | CCNYL1 | 0.759645 | 5 | 0 | 5 |
| GTF3C1 | CLIC3 | 0.754008 | 9 | 0 | 8 |
| GTF3C1 | MALL | 0.751943 | 11 | 0 | 10 |
| GTF3C1 | MFSD5 | 0.751219 | 12 | 0 | 11 |
| GTF3C1 | NLRX1 | 0.751034 | 11 | 0 | 10 |
| GTF3C1 | RECQL5 | 0.749671 | 11 | 0 | 11 |
| GTF3C1 | KCTD21 | 0.748573 | 3 | 0 | 3 |
| GTF3C1 | OTUB1 | 0.747687 | 3 | 0 | 3 |
| GTF3C1 | MLKL | 0.744364 | 3 | 0 | 3 |
| GTF3C1 | EHD3 | 0.743333 | 11 | 0 | 11 |
| GTF3C1 | SESN2 | 0.739066 | 6 | 0 | 6 |
| GTF3C1 | PADI1 | 0.738946 | 8 | 0 | 8 |
For details and further investigation, click here
