| Full name: EPH receptor B6 | Alias Symbol: HEP | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 2051 | HGNC ID: HGNC:3396 | Ensembl Gene: ENSG00000106123 | OMIM ID: 602757 |
| Drug and gene relationship at DGIdb | |||
EPHB6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHB6 | 2051 | 204718_at | -0.1440 | 0.7346 | |
| GSE20347 | EPHB6 | 2051 | 204718_at | -0.7908 | 0.0002 | |
| GSE23400 | EPHB6 | 2051 | 204718_at | -0.4570 | 0.0000 | |
| GSE26886 | EPHB6 | 2051 | 204718_at | 0.1802 | 0.5001 | |
| GSE29001 | EPHB6 | 2051 | 204718_at | -0.4977 | 0.0592 | |
| GSE38129 | EPHB6 | 2051 | 204718_at | -0.5512 | 0.0180 | |
| GSE45670 | EPHB6 | 2051 | 204718_at | -0.4106 | 0.1351 | |
| GSE53622 | EPHB6 | 2051 | 102723 | -1.1436 | 0.0000 | |
| GSE53624 | EPHB6 | 2051 | 102723 | -1.2087 | 0.0000 | |
| GSE63941 | EPHB6 | 2051 | 204718_at | 0.3340 | 0.2201 | |
| GSE77861 | EPHB6 | 2051 | 204718_at | -0.4448 | 0.2784 | |
| GSE97050 | EPHB6 | 2051 | A_23_P145935 | 0.0111 | 0.9764 | |
| SRP007169 | EPHB6 | 2051 | RNAseq | -0.2526 | 0.6241 | |
| SRP008496 | EPHB6 | 2051 | RNAseq | -0.0428 | 0.9350 | |
| SRP064894 | EPHB6 | 2051 | RNAseq | -1.0465 | 0.0032 | |
| SRP133303 | EPHB6 | 2051 | RNAseq | -1.2853 | 0.0004 | |
| SRP159526 | EPHB6 | 2051 | RNAseq | -0.0395 | 0.9562 | |
| SRP193095 | EPHB6 | 2051 | RNAseq | -1.0123 | 0.0002 | |
| SRP219564 | EPHB6 | 2051 | RNAseq | -1.7878 | 0.0025 | |
| TCGA | EPHB6 | 2051 | RNAseq | -0.0699 | 0.6955 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by EPHB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHB6 | 2051 | 4 | 2 | 24 | |
| GSE20123 | EPHB6 | 2051 | 4 | 2 | 24 | |
| GSE43470 | EPHB6 | 2051 | 2 | 4 | 37 | |
| GSE46452 | EPHB6 | 2051 | 7 | 2 | 50 | |
| GSE47630 | EPHB6 | 2051 | 6 | 7 | 27 | |
| GSE54993 | EPHB6 | 2051 | 3 | 4 | 63 | |
| GSE54994 | EPHB6 | 2051 | 5 | 8 | 40 | |
| GSE60625 | EPHB6 | 2051 | 0 | 0 | 11 | |
| GSE74703 | EPHB6 | 2051 | 2 | 4 | 30 | |
| GSE74704 | EPHB6 | 2051 | 2 | 2 | 16 | |
| TCGA | EPHB6 | 2051 | 28 | 23 | 45 |
Total number of gains: 63; Total number of losses: 58; Total Number of normals: 367.
Somatic mutations of EPHB6:
Generating mutation plots.
Highly correlated genes for EPHB6:
Showing top 20/529 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHB6 | SLC16A14 | 0.699667 | 4 | 0 | 4 |
| EPHB6 | ZKSCAN4 | 0.677063 | 3 | 0 | 3 |
| EPHB6 | NUMA1 | 0.675539 | 3 | 0 | 3 |
| EPHB6 | FBXL14 | 0.662423 | 4 | 0 | 4 |
| EPHB6 | ABHD16A | 0.660771 | 3 | 0 | 3 |
| EPHB6 | GLTP | 0.648862 | 7 | 0 | 6 |
| EPHB6 | ZNF480 | 0.648674 | 3 | 0 | 3 |
| EPHB6 | SLC9A9 | 0.647889 | 6 | 0 | 6 |
| EPHB6 | KIF21A | 0.647456 | 3 | 0 | 3 |
| EPHB6 | NDUFS3 | 0.647182 | 4 | 0 | 3 |
| EPHB6 | DBI | 0.645349 | 10 | 0 | 8 |
| EPHB6 | MUC20 | 0.640547 | 6 | 0 | 5 |
| EPHB6 | SERPINB11 | 0.629196 | 5 | 0 | 3 |
| EPHB6 | ALDH3B2 | 0.628402 | 7 | 0 | 6 |
| EPHB6 | SLC16A6 | 0.628314 | 8 | 0 | 8 |
| EPHB6 | ABHD12 | 0.621514 | 4 | 0 | 3 |
| EPHB6 | ALDH3A2 | 0.621191 | 9 | 0 | 8 |
| EPHB6 | PMF1 | 0.619391 | 3 | 0 | 3 |
| EPHB6 | API5 | 0.619066 | 3 | 0 | 3 |
| EPHB6 | RNF208 | 0.611443 | 6 | 0 | 4 |
For details and further investigation, click here
