| Full name: leucine rich transmembrane and O-methyltransferase domain containing | Alias Symbol: COMT2|CFAP111 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 220074 | HGNC ID: HGNC:25033 | Ensembl Gene: ENSG00000184154 | OMIM ID: 612414 |
| Drug and gene relationship at DGIdb | |||
Expression of LRTOMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRTOMT | 220074 | 226717_at | 0.3489 | 0.5709 | |
| GSE26886 | LRTOMT | 220074 | 226717_at | 0.2377 | 0.0610 | |
| GSE45670 | LRTOMT | 220074 | 226717_at | 0.0431 | 0.8493 | |
| GSE53622 | LRTOMT | 220074 | 65054 | 0.1022 | 0.5286 | |
| GSE53624 | LRTOMT | 220074 | 65054 | 0.0452 | 0.7504 | |
| GSE63941 | LRTOMT | 220074 | 226717_at | 0.8966 | 0.1492 | |
| GSE77861 | LRTOMT | 220074 | 226717_at | -0.1752 | 0.1641 | |
| GSE97050 | LRTOMT | 220074 | A_23_P98763 | 0.4209 | 0.5354 | |
| SRP007169 | LRTOMT | 220074 | RNAseq | -1.0618 | 0.0212 | |
| SRP008496 | LRTOMT | 220074 | RNAseq | -0.2574 | 0.4423 | |
| SRP064894 | LRTOMT | 220074 | RNAseq | -0.3019 | 0.1915 | |
| SRP133303 | LRTOMT | 220074 | RNAseq | 0.5265 | 0.0608 | |
| SRP159526 | LRTOMT | 220074 | RNAseq | -0.5967 | 0.0120 | |
| SRP193095 | LRTOMT | 220074 | RNAseq | -0.0614 | 0.6933 | |
| SRP219564 | LRTOMT | 220074 | RNAseq | -0.3205 | 0.3057 | |
| TCGA | LRTOMT | 220074 | RNAseq | -0.1028 | 0.3954 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LRTOMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRTOMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRTOMT | 220074 | 10 | 7 | 13 | |
| GSE20123 | LRTOMT | 220074 | 10 | 7 | 13 | |
| GSE43470 | LRTOMT | 220074 | 9 | 4 | 30 | |
| GSE46452 | LRTOMT | 220074 | 13 | 16 | 30 | |
| GSE47630 | LRTOMT | 220074 | 10 | 10 | 20 | |
| GSE54993 | LRTOMT | 220074 | 7 | 3 | 60 | |
| GSE54994 | LRTOMT | 220074 | 14 | 11 | 28 | |
| GSE60625 | LRTOMT | 220074 | 0 | 7 | 4 | |
| GSE74703 | LRTOMT | 220074 | 7 | 3 | 26 | |
| GSE74704 | LRTOMT | 220074 | 7 | 4 | 9 | |
| TCGA | LRTOMT | 220074 | 36 | 20 | 40 |
Total number of gains: 123; Total number of losses: 92; Total Number of normals: 273.
Somatic mutations of LRTOMT:
Generating mutation plots.
Highly correlated genes for LRTOMT:
Showing top 20/152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRTOMT | C2CD2 | 0.778105 | 3 | 0 | 3 |
| LRTOMT | PTPRU | 0.770649 | 3 | 0 | 3 |
| LRTOMT | RABEP2 | 0.7685 | 3 | 0 | 3 |
| LRTOMT | MPV17L | 0.761895 | 3 | 0 | 3 |
| LRTOMT | POLA2 | 0.751114 | 3 | 0 | 3 |
| LRTOMT | GYG2 | 0.748032 | 3 | 0 | 3 |
| LRTOMT | ERP27 | 0.747176 | 3 | 0 | 3 |
| LRTOMT | TADA3 | 0.743185 | 3 | 0 | 3 |
| LRTOMT | NDUFAF3 | 0.735438 | 3 | 0 | 3 |
| LRTOMT | PYGO1 | 0.731183 | 3 | 0 | 3 |
| LRTOMT | USP13 | 0.730071 | 4 | 0 | 3 |
| LRTOMT | SEMA4A | 0.729473 | 3 | 0 | 3 |
| LRTOMT | PRTN3 | 0.728076 | 3 | 0 | 3 |
| LRTOMT | CATSPER1 | 0.727871 | 3 | 0 | 3 |
| LRTOMT | PRDX4 | 0.724449 | 3 | 0 | 3 |
| LRTOMT | SLC25A35 | 0.718055 | 3 | 0 | 3 |
| LRTOMT | BRI3 | 0.711557 | 3 | 0 | 3 |
| LRTOMT | NFKB1 | 0.707167 | 3 | 0 | 3 |
| LRTOMT | MOSPD3 | 0.703529 | 4 | 0 | 3 |
| LRTOMT | RNF208 | 0.701418 | 3 | 0 | 3 |
For details and further investigation, click here
