| Full name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Alias Symbol: FLJ20625|p18|p27RF-Rho|Pdro|Ragulator1 | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 55004 | HGNC ID: HGNC:26068 | Ensembl Gene: ENSG00000149357 | OMIM ID: 613510 |
Screen Evidence:
| |||
LAMTOR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway |
Expression of LAMTOR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMTOR1 | 55004 | 223009_at | 0.6965 | 0.1637 | |
| GSE26886 | LAMTOR1 | 55004 | 223009_at | 0.2428 | 0.2238 | |
| GSE45670 | LAMTOR1 | 55004 | 223009_at | 0.1773 | 0.3847 | |
| GSE53622 | LAMTOR1 | 55004 | 31266 | 0.0201 | 0.8557 | |
| GSE53624 | LAMTOR1 | 55004 | 31266 | 0.1512 | 0.0318 | |
| GSE63941 | LAMTOR1 | 55004 | 223009_at | -0.1449 | 0.7937 | |
| GSE77861 | LAMTOR1 | 55004 | 223009_at | -0.1141 | 0.6894 | |
| GSE97050 | LAMTOR1 | 55004 | A_23_P2114 | 0.4647 | 0.2726 | |
| SRP007169 | LAMTOR1 | 55004 | RNAseq | -0.9373 | 0.0055 | |
| SRP008496 | LAMTOR1 | 55004 | RNAseq | -0.6795 | 0.0093 | |
| SRP064894 | LAMTOR1 | 55004 | RNAseq | 0.2730 | 0.3673 | |
| SRP133303 | LAMTOR1 | 55004 | RNAseq | 1.0951 | 0.0050 | |
| SRP159526 | LAMTOR1 | 55004 | RNAseq | -0.6504 | 0.0366 | |
| SRP193095 | LAMTOR1 | 55004 | RNAseq | -0.1494 | 0.4821 | |
| SRP219564 | LAMTOR1 | 55004 | RNAseq | 0.0127 | 0.9745 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LAMTOR1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of LAMTOR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMTOR1 | 55004 | 10 | 7 | 13 | |
| GSE20123 | LAMTOR1 | 55004 | 10 | 7 | 13 | |
| GSE43470 | LAMTOR1 | 55004 | 9 | 4 | 30 | |
| GSE46452 | LAMTOR1 | 55004 | 12 | 17 | 30 | |
| GSE47630 | LAMTOR1 | 55004 | 10 | 10 | 20 | |
| GSE54993 | LAMTOR1 | 55004 | 7 | 3 | 60 | |
| GSE54994 | LAMTOR1 | 55004 | 14 | 11 | 28 | |
| GSE60625 | LAMTOR1 | 55004 | 0 | 7 | 4 | |
| GSE74703 | LAMTOR1 | 55004 | 7 | 3 | 26 | |
| GSE74704 | LAMTOR1 | 55004 | 7 | 4 | 9 | |
| TCGA | LAMTOR1 | 55004 | 36 | 20 | 40 |
Total number of gains: 122; Total number of losses: 93; Total Number of normals: 273.
Somatic mutations of LAMTOR1:
Generating mutation plots.
Highly correlated genes for LAMTOR1:
Showing top 20/104 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMTOR1 | MAGED1 | 0.781428 | 3 | 0 | 3 |
| LAMTOR1 | FAM171B | 0.761628 | 3 | 0 | 3 |
| LAMTOR1 | GABPB1 | 0.760999 | 3 | 0 | 3 |
| LAMTOR1 | SLC30A6 | 0.759439 | 3 | 0 | 3 |
| LAMTOR1 | CCDC117 | 0.756332 | 3 | 0 | 3 |
| LAMTOR1 | CENPW | 0.751323 | 3 | 0 | 3 |
| LAMTOR1 | PRMT6 | 0.744939 | 3 | 0 | 3 |
| LAMTOR1 | STOML1 | 0.738435 | 3 | 0 | 3 |
| LAMTOR1 | GSPT1 | 0.727102 | 3 | 0 | 3 |
| LAMTOR1 | MGAT2 | 0.725662 | 4 | 0 | 4 |
| LAMTOR1 | RNASEH1 | 0.722584 | 3 | 0 | 3 |
| LAMTOR1 | XRCC6 | 0.722153 | 3 | 0 | 3 |
| LAMTOR1 | RNF40 | 0.719025 | 3 | 0 | 3 |
| LAMTOR1 | NUMA1 | 0.717588 | 7 | 0 | 7 |
| LAMTOR1 | ALDH5A1 | 0.712114 | 3 | 0 | 3 |
| LAMTOR1 | ANAPC15 | 0.708356 | 7 | 0 | 7 |
| LAMTOR1 | PAQR4 | 0.701664 | 3 | 0 | 3 |
| LAMTOR1 | THBD | 0.701264 | 3 | 0 | 3 |
| LAMTOR1 | FTSJ1 | 0.700626 | 3 | 0 | 3 |
| LAMTOR1 | DONSON | 0.700189 | 3 | 0 | 3 |
For details and further investigation, click here
