| Full name: abl interactor 2 | Alias Symbol: ABI-2|AIP-1|ABI2B|AblBP3|argBPIA|SSH3BP2 | ||
| Type: protein-coding gene | Cytoband: 2q33.2 | ||
| Entrez ID: 10152 | HGNC ID: HGNC:24011 | Ensembl Gene: ENSG00000138443 | OMIM ID: 606442 |
| Drug and gene relationship at DGIdb | |||
ABI2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ABI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABI2 | 10152 | 225098_at | -0.3228 | 0.6232 | |
| GSE20347 | ABI2 | 10152 | 209856_x_at | 0.4899 | 0.0000 | |
| GSE23400 | ABI2 | 10152 | 207268_x_at | 0.0576 | 0.1927 | |
| GSE26886 | ABI2 | 10152 | 225112_at | 0.8431 | 0.0102 | |
| GSE29001 | ABI2 | 10152 | 207268_x_at | 0.2375 | 0.1630 | |
| GSE38129 | ABI2 | 10152 | 207268_x_at | 0.6715 | 0.0000 | |
| GSE45670 | ABI2 | 10152 | 225098_at | -0.5708 | 0.0127 | |
| GSE53622 | ABI2 | 10152 | 21969 | 0.0567 | 0.7018 | |
| GSE53624 | ABI2 | 10152 | 21969 | 0.0634 | 0.5505 | |
| GSE63941 | ABI2 | 10152 | 211793_s_at | 0.8220 | 0.0085 | |
| GSE77861 | ABI2 | 10152 | 225112_at | 0.4872 | 0.0640 | |
| GSE97050 | ABI2 | 10152 | A_24_P933418 | -0.5087 | 0.2469 | |
| SRP007169 | ABI2 | 10152 | RNAseq | 1.4585 | 0.0001 | |
| SRP008496 | ABI2 | 10152 | RNAseq | 1.5499 | 0.0000 | |
| SRP064894 | ABI2 | 10152 | RNAseq | 0.1494 | 0.2853 | |
| SRP133303 | ABI2 | 10152 | RNAseq | 0.2603 | 0.0577 | |
| SRP159526 | ABI2 | 10152 | RNAseq | 0.4964 | 0.1497 | |
| SRP193095 | ABI2 | 10152 | RNAseq | 0.4046 | 0.0007 | |
| SRP219564 | ABI2 | 10152 | RNAseq | -0.1181 | 0.8111 | |
| TCGA | ABI2 | 10152 | RNAseq | -0.0942 | 0.2001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ABI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABI2 | 10152 | 7 | 4 | 19 | |
| GSE20123 | ABI2 | 10152 | 7 | 4 | 19 | |
| GSE43470 | ABI2 | 10152 | 2 | 4 | 37 | |
| GSE46452 | ABI2 | 10152 | 1 | 4 | 54 | |
| GSE47630 | ABI2 | 10152 | 4 | 5 | 31 | |
| GSE54993 | ABI2 | 10152 | 0 | 3 | 67 | |
| GSE54994 | ABI2 | 10152 | 10 | 8 | 35 | |
| GSE60625 | ABI2 | 10152 | 0 | 3 | 8 | |
| GSE74703 | ABI2 | 10152 | 2 | 3 | 31 | |
| GSE74704 | ABI2 | 10152 | 3 | 2 | 15 | |
| TCGA | ABI2 | 10152 | 20 | 13 | 63 |
Total number of gains: 56; Total number of losses: 53; Total Number of normals: 379.
Somatic mutations of ABI2:
Generating mutation plots.
Highly correlated genes for ABI2:
Showing top 20/732 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABI2 | KCTD7 | 0.775158 | 3 | 0 | 3 |
| ABI2 | STRADA | 0.768771 | 3 | 0 | 3 |
| ABI2 | RCOR3 | 0.75417 | 3 | 0 | 3 |
| ABI2 | PXN | 0.745383 | 3 | 0 | 3 |
| ABI2 | WIPF3 | 0.739018 | 3 | 0 | 3 |
| ABI2 | SSBP4 | 0.732352 | 3 | 0 | 3 |
| ABI2 | CCDC28A | 0.721354 | 3 | 0 | 3 |
| ABI2 | CLIP2 | 0.71921 | 3 | 0 | 3 |
| ABI2 | MAP1LC3A | 0.718921 | 3 | 0 | 3 |
| ABI2 | TBC1D16 | 0.718756 | 3 | 0 | 3 |
| ABI2 | DDHD1 | 0.717935 | 3 | 0 | 3 |
| ABI2 | BANF1 | 0.716873 | 5 | 0 | 5 |
| ABI2 | CCDC85B | 0.716756 | 3 | 0 | 3 |
| ABI2 | TLE1 | 0.715815 | 3 | 0 | 3 |
| ABI2 | NCOR2 | 0.712617 | 3 | 0 | 3 |
| ABI2 | TTC3 | 0.711039 | 3 | 0 | 3 |
| ABI2 | SLC41A1 | 0.7094 | 3 | 0 | 3 |
| ABI2 | FAN1 | 0.709265 | 3 | 0 | 3 |
| ABI2 | ZNF532 | 0.707227 | 3 | 0 | 3 |
| ABI2 | LGI2 | 0.705689 | 3 | 0 | 3 |
For details and further investigation, click here
