| Full name: recombination signal binding protein for immunoglobulin kappa J region | Alias Symbol: SUH|IGKJRB|RBPJK|KBF2|RBP-J|CBF1 | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 3516 | HGNC ID: HGNC:5724 | Ensembl Gene: ENSG00000168214 | OMIM ID: 147183 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RBPJ involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway | |
| hsa05169 | Epstein-Barr virus infection |
Expression of RBPJ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBPJ | 3516 | 211974_x_at | -0.0044 | 0.9955 | |
| GSE20347 | RBPJ | 3516 | 211974_x_at | 0.1927 | 0.2881 | |
| GSE23400 | RBPJ | 3516 | 211974_x_at | 0.0777 | 0.2306 | |
| GSE26886 | RBPJ | 3516 | 211974_x_at | 0.1788 | 0.5695 | |
| GSE29001 | RBPJ | 3516 | 211974_x_at | 0.2702 | 0.1386 | |
| GSE38129 | RBPJ | 3516 | 211974_x_at | -0.0768 | 0.6472 | |
| GSE45670 | RBPJ | 3516 | 211974_x_at | -0.5791 | 0.0000 | |
| GSE53622 | RBPJ | 3516 | 88784 | 0.0469 | 0.4486 | |
| GSE53624 | RBPJ | 3516 | 88784 | 0.0371 | 0.6269 | |
| GSE63941 | RBPJ | 3516 | 211974_x_at | -1.6806 | 0.0005 | |
| GSE77861 | RBPJ | 3516 | 211974_x_at | 0.2360 | 0.4208 | |
| GSE97050 | RBPJ | 3516 | A_23_P29994 | -0.3108 | 0.2067 | |
| SRP007169 | RBPJ | 3516 | RNAseq | 0.5628 | 0.0783 | |
| SRP008496 | RBPJ | 3516 | RNAseq | 0.8167 | 0.0036 | |
| SRP064894 | RBPJ | 3516 | RNAseq | -0.0445 | 0.8203 | |
| SRP133303 | RBPJ | 3516 | RNAseq | 0.0860 | 0.6310 | |
| SRP159526 | RBPJ | 3516 | RNAseq | 0.0075 | 0.9814 | |
| SRP193095 | RBPJ | 3516 | RNAseq | 0.0819 | 0.4487 | |
| SRP219564 | RBPJ | 3516 | RNAseq | 0.1611 | 0.4562 | |
| TCGA | RBPJ | 3516 | RNAseq | -0.1303 | 0.0069 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RBPJ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBPJ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBPJ | 3516 | 0 | 18 | 12 | |
| GSE20123 | RBPJ | 3516 | 0 | 16 | 14 | |
| GSE43470 | RBPJ | 3516 | 0 | 14 | 29 | |
| GSE46452 | RBPJ | 3516 | 1 | 36 | 22 | |
| GSE47630 | RBPJ | 3516 | 1 | 19 | 20 | |
| GSE54993 | RBPJ | 3516 | 9 | 0 | 61 | |
| GSE54994 | RBPJ | 3516 | 5 | 11 | 37 | |
| GSE60625 | RBPJ | 3516 | 0 | 0 | 11 | |
| GSE74703 | RBPJ | 3516 | 0 | 12 | 24 | |
| GSE74704 | RBPJ | 3516 | 0 | 10 | 10 | |
| TCGA | RBPJ | 3516 | 11 | 47 | 38 |
Total number of gains: 27; Total number of losses: 183; Total Number of normals: 278.
Somatic mutations of RBPJ:
Generating mutation plots.
Highly correlated genes for RBPJ:
Showing top 20/685 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBPJ | MRVI1 | 0.819776 | 3 | 0 | 3 |
| RBPJ | ATP6V1H | 0.809432 | 3 | 0 | 3 |
| RBPJ | DROSHA | 0.784961 | 3 | 0 | 3 |
| RBPJ | RHOU | 0.78158 | 3 | 0 | 3 |
| RBPJ | MYOCD | 0.78069 | 3 | 0 | 3 |
| RBPJ | PRRX1 | 0.776614 | 3 | 0 | 3 |
| RBPJ | GOLPH3 | 0.770731 | 3 | 0 | 3 |
| RBPJ | C11orf96 | 0.769102 | 3 | 0 | 3 |
| RBPJ | EPDR1 | 0.763817 | 3 | 0 | 3 |
| RBPJ | DAP | 0.756989 | 3 | 0 | 3 |
| RBPJ | S1PR1 | 0.751234 | 4 | 0 | 3 |
| RBPJ | FKBP5 | 0.751155 | 3 | 0 | 3 |
| RBPJ | RB1CC1 | 0.747785 | 3 | 0 | 3 |
| RBPJ | RICTOR | 0.743697 | 3 | 0 | 3 |
| RBPJ | MAK16 | 0.741764 | 3 | 0 | 3 |
| RBPJ | YTHDF3 | 0.741702 | 4 | 0 | 4 |
| RBPJ | CCL8 | 0.741237 | 3 | 0 | 3 |
| RBPJ | CDH6 | 0.727334 | 3 | 0 | 3 |
| RBPJ | CNRIP1 | 0.726225 | 4 | 0 | 3 |
| RBPJ | TGFBR3 | 0.724153 | 3 | 0 | 3 |
For details and further investigation, click here
