| Full name: VPS28 subunit of ESCRT-I | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 51160 | HGNC ID: HGNC:18178 | Ensembl Gene: ENSG00000160948 | OMIM ID: 611952 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of VPS28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS28 | 51160 | 218679_s_at | -0.0651 | 0.8667 | |
| GSE20347 | VPS28 | 51160 | 218679_s_at | -0.3196 | 0.0120 | |
| GSE23400 | VPS28 | 51160 | 218679_s_at | -0.0178 | 0.8026 | |
| GSE26886 | VPS28 | 51160 | 218679_s_at | 0.0239 | 0.9486 | |
| GSE29001 | VPS28 | 51160 | 218679_s_at | -0.4923 | 0.1967 | |
| GSE38129 | VPS28 | 51160 | 218679_s_at | -0.2869 | 0.0030 | |
| GSE45670 | VPS28 | 51160 | 218679_s_at | -0.0966 | 0.4601 | |
| GSE53622 | VPS28 | 51160 | 15374 | -0.2020 | 0.0008 | |
| GSE53624 | VPS28 | 51160 | 15374 | -0.1182 | 0.0495 | |
| GSE63941 | VPS28 | 51160 | 218679_s_at | 0.0676 | 0.9096 | |
| GSE77861 | VPS28 | 51160 | 218679_s_at | -0.2060 | 0.3204 | |
| GSE97050 | VPS28 | 51160 | A_23_P31903 | -0.1187 | 0.6208 | |
| SRP007169 | VPS28 | 51160 | RNAseq | -1.2526 | 0.0001 | |
| SRP008496 | VPS28 | 51160 | RNAseq | -0.9004 | 0.0000 | |
| SRP064894 | VPS28 | 51160 | RNAseq | 0.4213 | 0.1965 | |
| SRP133303 | VPS28 | 51160 | RNAseq | -0.2861 | 0.0734 | |
| SRP159526 | VPS28 | 51160 | RNAseq | -0.1143 | 0.4844 | |
| SRP193095 | VPS28 | 51160 | RNAseq | -0.2445 | 0.0659 | |
| SRP219564 | VPS28 | 51160 | RNAseq | 0.0665 | 0.8523 | |
| TCGA | VPS28 | 51160 | RNAseq | -0.0351 | 0.5482 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by VPS28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS28 | 51160 | 17 | 1 | 12 | |
| GSE20123 | VPS28 | 51160 | 17 | 1 | 12 | |
| GSE43470 | VPS28 | 51160 | 16 | 2 | 25 | |
| GSE46452 | VPS28 | 51160 | 28 | 0 | 31 | |
| GSE47630 | VPS28 | 51160 | 25 | 1 | 14 | |
| GSE54993 | VPS28 | 51160 | 0 | 25 | 45 | |
| GSE54994 | VPS28 | 51160 | 39 | 1 | 13 | |
| GSE60625 | VPS28 | 51160 | 3 | 4 | 4 | |
| GSE74703 | VPS28 | 51160 | 14 | 1 | 21 | |
| GSE74704 | VPS28 | 51160 | 10 | 0 | 10 | |
| TCGA | VPS28 | 51160 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of VPS28:
Generating mutation plots.
Highly correlated genes for VPS28:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS28 | NIT2 | 0.784201 | 3 | 0 | 3 |
| VPS28 | ADCK1 | 0.756185 | 3 | 0 | 3 |
| VPS28 | VTI1B | 0.749234 | 3 | 0 | 3 |
| VPS28 | ACO2 | 0.747799 | 3 | 0 | 3 |
| VPS28 | NXF1 | 0.741138 | 3 | 0 | 3 |
| VPS28 | RPS4X | 0.735812 | 3 | 0 | 3 |
| VPS28 | TAGAP | 0.73221 | 3 | 0 | 3 |
| VPS28 | SURF1 | 0.73171 | 3 | 0 | 3 |
| VPS28 | RCSD1 | 0.725656 | 3 | 0 | 3 |
| VPS28 | HERPUD1 | 0.715133 | 3 | 0 | 3 |
| VPS28 | HMGN2 | 0.714879 | 3 | 0 | 3 |
| VPS28 | AHCY | 0.712622 | 3 | 0 | 3 |
| VPS28 | UBXN1 | 0.708565 | 4 | 0 | 3 |
| VPS28 | RPH3AL | 0.70565 | 3 | 0 | 3 |
| VPS28 | OGG1 | 0.704653 | 3 | 0 | 3 |
| VPS28 | PLXNB2 | 0.701415 | 3 | 0 | 3 |
| VPS28 | NCKAP1L | 0.698125 | 3 | 0 | 3 |
| VPS28 | ANKRD44 | 0.697403 | 4 | 0 | 3 |
| VPS28 | GPRC5B | 0.696761 | 3 | 0 | 3 |
| VPS28 | DOK1 | 0.694607 | 3 | 0 | 3 |
For details and further investigation, click here
