| Full name: opioid receptor kappa 1 | Alias Symbol: KOR|OPRK | ||
| Type: protein-coding gene | Cytoband: 8q11.23 | ||
| Entrez ID: 4986 | HGNC ID: HGNC:8154 | Ensembl Gene: ENSG00000082556 | OMIM ID: 165196 |
| Drug and gene relationship at DGIdb | |||
Expression of OPRK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OPRK1 | 4986 | 207553_at | -0.0355 | 0.9147 | |
| GSE20347 | OPRK1 | 4986 | 207553_at | 0.0395 | 0.7487 | |
| GSE23400 | OPRK1 | 4986 | 207553_at | -0.0764 | 0.0321 | |
| GSE26886 | OPRK1 | 4986 | 207553_at | -0.0063 | 0.9684 | |
| GSE29001 | OPRK1 | 4986 | 207553_at | -0.0255 | 0.8840 | |
| GSE38129 | OPRK1 | 4986 | 207553_at | 0.1914 | 0.1373 | |
| GSE45670 | OPRK1 | 4986 | 207553_at | 0.2599 | 0.0049 | |
| GSE53622 | OPRK1 | 4986 | 28837 | 0.1661 | 0.0553 | |
| GSE53624 | OPRK1 | 4986 | 28837 | -0.5229 | 0.0000 | |
| GSE63941 | OPRK1 | 4986 | 207553_at | 0.2794 | 0.1976 | |
| GSE77861 | OPRK1 | 4986 | 207553_at | -0.0378 | 0.7596 | |
| SRP133303 | OPRK1 | 4986 | RNAseq | 0.3438 | 0.2804 | |
| TCGA | OPRK1 | 4986 | RNAseq | 3.0645 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by OPRK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OPRK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OPRK1 | 4986 | 15 | 2 | 13 | |
| GSE20123 | OPRK1 | 4986 | 15 | 2 | 13 | |
| GSE43470 | OPRK1 | 4986 | 14 | 3 | 26 | |
| GSE46452 | OPRK1 | 4986 | 21 | 3 | 35 | |
| GSE47630 | OPRK1 | 4986 | 23 | 1 | 16 | |
| GSE54993 | OPRK1 | 4986 | 1 | 16 | 53 | |
| GSE54994 | OPRK1 | 4986 | 28 | 0 | 25 | |
| GSE60625 | OPRK1 | 4986 | 0 | 4 | 7 | |
| GSE74703 | OPRK1 | 4986 | 13 | 2 | 21 | |
| GSE74704 | OPRK1 | 4986 | 11 | 0 | 9 | |
| TCGA | OPRK1 | 4986 | 43 | 9 | 44 |
Total number of gains: 184; Total number of losses: 42; Total Number of normals: 262.
Somatic mutations of OPRK1:
Generating mutation plots.
Highly correlated genes for OPRK1:
Showing top 20/396 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OPRK1 | OR10J1 | 0.757186 | 3 | 0 | 3 |
| OPRK1 | BIRC7 | 0.730789 | 3 | 0 | 3 |
| OPRK1 | CST8 | 0.722948 | 3 | 0 | 3 |
| OPRK1 | ATP8B3 | 0.709814 | 4 | 0 | 4 |
| OPRK1 | TESPA1 | 0.702523 | 3 | 0 | 3 |
| OPRK1 | LCT | 0.700315 | 5 | 0 | 5 |
| OPRK1 | SCGB1D1 | 0.698102 | 3 | 0 | 3 |
| OPRK1 | VGF | 0.697444 | 4 | 0 | 4 |
| OPRK1 | LINC00837 | 0.695254 | 3 | 0 | 3 |
| OPRK1 | LZTS1 | 0.687659 | 4 | 0 | 4 |
| OPRK1 | P2RX6 | 0.683763 | 4 | 0 | 4 |
| OPRK1 | F11 | 0.682166 | 3 | 0 | 3 |
| OPRK1 | KIAA0087 | 0.681839 | 3 | 0 | 3 |
| OPRK1 | SGK2 | 0.678245 | 3 | 0 | 3 |
| OPRK1 | MAG | 0.676608 | 3 | 0 | 3 |
| OPRK1 | IL17A | 0.673149 | 4 | 0 | 3 |
| OPRK1 | LUZP4 | 0.669804 | 3 | 0 | 3 |
| OPRK1 | FGF4 | 0.66939 | 3 | 0 | 3 |
| OPRK1 | PSG9 | 0.667729 | 4 | 0 | 4 |
| OPRK1 | GABRD | 0.664948 | 3 | 0 | 3 |
For details and further investigation, click here
