| Full name: lactase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q21.3 | ||
| Entrez ID: 3938 | HGNC ID: HGNC:6530 | Ensembl Gene: ENSG00000115850 | OMIM ID: 603202 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LCT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LCT | 3938 | 206945_at | -0.0852 | 0.7026 | |
| GSE20347 | LCT | 3938 | 206945_at | 0.0377 | 0.7636 | |
| GSE23400 | LCT | 3938 | 206945_at | -0.2192 | 0.0000 | |
| GSE26886 | LCT | 3938 | 206945_at | 0.0020 | 0.9901 | |
| GSE29001 | LCT | 3938 | 206945_at | -0.0452 | 0.8222 | |
| GSE38129 | LCT | 3938 | 206945_at | -0.0282 | 0.8219 | |
| GSE45670 | LCT | 3938 | 206945_at | 0.1770 | 0.1325 | |
| GSE53622 | LCT | 3938 | 112917 | 0.2119 | 0.0184 | |
| GSE53624 | LCT | 3938 | 112917 | 0.3391 | 0.0000 | |
| GSE63941 | LCT | 3938 | 206945_at | 0.0475 | 0.8381 | |
| GSE77861 | LCT | 3938 | 206945_at | -0.1244 | 0.2334 | |
| GSE97050 | LCT | 3938 | A_23_P79217 | 0.1465 | 0.5191 | |
| TCGA | LCT | 3938 | RNAseq | 2.3321 | 0.0098 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LCT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LCT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LCT | 3938 | 2 | 4 | 24 | |
| GSE20123 | LCT | 3938 | 2 | 4 | 24 | |
| GSE43470 | LCT | 3938 | 2 | 1 | 40 | |
| GSE46452 | LCT | 3938 | 1 | 4 | 54 | |
| GSE47630 | LCT | 3938 | 5 | 2 | 33 | |
| GSE54993 | LCT | 3938 | 0 | 6 | 64 | |
| GSE54994 | LCT | 3938 | 9 | 0 | 44 | |
| GSE60625 | LCT | 3938 | 0 | 3 | 8 | |
| GSE74703 | LCT | 3938 | 2 | 1 | 33 | |
| GSE74704 | LCT | 3938 | 1 | 1 | 18 | |
| TCGA | LCT | 3938 | 21 | 10 | 65 |
Total number of gains: 45; Total number of losses: 36; Total Number of normals: 407.
Somatic mutations of LCT:
Generating mutation plots.
Highly correlated genes for LCT:
Showing top 20/887 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LCT | OBSL1 | 0.831207 | 3 | 0 | 3 |
| LCT | SHANK1 | 0.775185 | 3 | 0 | 3 |
| LCT | C10orf90 | 0.756211 | 4 | 0 | 4 |
| LCT | LRRC31 | 0.753508 | 4 | 0 | 4 |
| LCT | PKLR | 0.750613 | 4 | 0 | 3 |
| LCT | TRIM17 | 0.750376 | 3 | 0 | 3 |
| LCT | TTR | 0.744681 | 4 | 0 | 4 |
| LCT | HCRTR1 | 0.735719 | 3 | 0 | 3 |
| LCT | DGCR6L | 0.73403 | 3 | 0 | 3 |
| LCT | AGRP | 0.729941 | 5 | 0 | 4 |
| LCT | REG3A | 0.727904 | 4 | 0 | 4 |
| LCT | SLC6A12 | 0.725315 | 4 | 0 | 4 |
| LCT | ADAMTS12 | 0.724022 | 4 | 0 | 4 |
| LCT | DIO3 | 0.723907 | 4 | 0 | 4 |
| LCT | RNF17 | 0.718547 | 5 | 0 | 4 |
| LCT | SLC30A3 | 0.714765 | 8 | 0 | 8 |
| LCT | DNMT3L | 0.714366 | 3 | 0 | 3 |
| LCT | ADAMTS6 | 0.711444 | 5 | 0 | 5 |
| LCT | IQSEC3 | 0.705994 | 5 | 0 | 5 |
| LCT | TRPV3 | 0.705238 | 3 | 0 | 3 |
For details and further investigation, click here
