| Full name: ORAI calcium release-activated calcium modulator 3 | Alias Symbol: MGC13024 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 93129 | HGNC ID: HGNC:28185 | Ensembl Gene: ENSG00000175938 | OMIM ID: 610930 |
| Drug and gene relationship at DGIdb | |||
ORAI3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of ORAI3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORAI3 | 93129 | 221864_at | -0.2748 | 0.5152 | |
| GSE20347 | ORAI3 | 93129 | 221864_at | 0.0467 | 0.8398 | |
| GSE23400 | ORAI3 | 93129 | 221864_at | 0.0040 | 0.9544 | |
| GSE26886 | ORAI3 | 93129 | 221864_at | 0.3271 | 0.3224 | |
| GSE29001 | ORAI3 | 93129 | 221864_at | 0.1118 | 0.7404 | |
| GSE38129 | ORAI3 | 93129 | 221864_at | -0.0901 | 0.6076 | |
| GSE45670 | ORAI3 | 93129 | 221864_at | -0.2670 | 0.2811 | |
| GSE63941 | ORAI3 | 93129 | 221864_at | -1.1787 | 0.0862 | |
| GSE77861 | ORAI3 | 93129 | 221864_at | 0.3156 | 0.2301 | |
| GSE97050 | ORAI3 | 93129 | A_23_P106898 | -0.2609 | 0.2616 | |
| SRP007169 | ORAI3 | 93129 | RNAseq | 0.6363 | 0.2474 | |
| SRP008496 | ORAI3 | 93129 | RNAseq | 0.9201 | 0.0097 | |
| SRP064894 | ORAI3 | 93129 | RNAseq | 0.3992 | 0.2094 | |
| SRP133303 | ORAI3 | 93129 | RNAseq | 0.1006 | 0.6334 | |
| SRP159526 | ORAI3 | 93129 | RNAseq | 0.1372 | 0.6872 | |
| SRP193095 | ORAI3 | 93129 | RNAseq | 0.1342 | 0.3215 | |
| SRP219564 | ORAI3 | 93129 | RNAseq | 0.2486 | 0.5877 | |
| TCGA | ORAI3 | 93129 | RNAseq | 0.0750 | 0.3623 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ORAI3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ORAI3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORAI3 | 93129 | 5 | 5 | 20 | |
| GSE20123 | ORAI3 | 93129 | 5 | 4 | 21 | |
| GSE43470 | ORAI3 | 93129 | 3 | 3 | 37 | |
| GSE46452 | ORAI3 | 93129 | 38 | 1 | 20 | |
| GSE47630 | ORAI3 | 93129 | 11 | 7 | 22 | |
| GSE54993 | ORAI3 | 93129 | 2 | 5 | 63 | |
| GSE54994 | ORAI3 | 93129 | 5 | 9 | 39 | |
| GSE60625 | ORAI3 | 93129 | 4 | 0 | 7 | |
| GSE74703 | ORAI3 | 93129 | 3 | 2 | 31 | |
| GSE74704 | ORAI3 | 93129 | 3 | 2 | 15 | |
| TCGA | ORAI3 | 93129 | 20 | 10 | 66 |
Total number of gains: 99; Total number of losses: 48; Total Number of normals: 341.
Somatic mutations of ORAI3:
Generating mutation plots.
Highly correlated genes for ORAI3:
Showing top 20/356 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORAI3 | BVES | 0.827305 | 3 | 0 | 3 |
| ORAI3 | NUDT2 | 0.810746 | 3 | 0 | 3 |
| ORAI3 | R3HDM2 | 0.787765 | 3 | 0 | 3 |
| ORAI3 | SMAD4 | 0.774985 | 3 | 0 | 3 |
| ORAI3 | HNRNPA0 | 0.774086 | 3 | 0 | 3 |
| ORAI3 | CEP44 | 0.757581 | 3 | 0 | 3 |
| ORAI3 | C11orf68 | 0.741786 | 3 | 0 | 3 |
| ORAI3 | MIF4GD | 0.740208 | 3 | 0 | 3 |
| ORAI3 | VPS39 | 0.740002 | 3 | 0 | 3 |
| ORAI3 | TMEM219 | 0.735328 | 3 | 0 | 3 |
| ORAI3 | ATP2A3 | 0.731976 | 3 | 0 | 3 |
| ORAI3 | NR2F2 | 0.72819 | 4 | 0 | 3 |
| ORAI3 | CDC42EP4 | 0.725754 | 3 | 0 | 3 |
| ORAI3 | GPATCH1 | 0.724499 | 3 | 0 | 3 |
| ORAI3 | ABCA3 | 0.72006 | 4 | 0 | 4 |
| ORAI3 | STAU1 | 0.718385 | 3 | 0 | 3 |
| ORAI3 | TRIM44 | 0.713845 | 3 | 0 | 3 |
| ORAI3 | TBC1D8 | 0.713732 | 3 | 0 | 3 |
| ORAI3 | UFC1 | 0.713225 | 3 | 0 | 3 |
| ORAI3 | SNAPIN | 0.712318 | 3 | 0 | 3 |
For details and further investigation, click here
