| Full name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 | Alias Symbol: SERCA3 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 489 | HGNC ID: HGNC:813 | Ensembl Gene: ENSG00000074370 | OMIM ID: 601929 |
| Drug and gene relationship at DGIdb | |||
ATP2A3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway |
Expression of ATP2A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP2A3 | 489 | 213036_x_at | -0.1595 | 0.8695 | |
| GSE20347 | ATP2A3 | 489 | 213036_x_at | 0.0635 | 0.6184 | |
| GSE23400 | ATP2A3 | 489 | 213036_x_at | -0.3307 | 0.0000 | |
| GSE26886 | ATP2A3 | 489 | 213036_x_at | 0.4668 | 0.0101 | |
| GSE29001 | ATP2A3 | 489 | 213036_x_at | -0.0534 | 0.8276 | |
| GSE38129 | ATP2A3 | 489 | 213036_x_at | -0.3172 | 0.2343 | |
| GSE45670 | ATP2A3 | 489 | 213036_x_at | -0.2730 | 0.1006 | |
| GSE53622 | ATP2A3 | 489 | 73925 | -0.9513 | 0.0000 | |
| GSE53624 | ATP2A3 | 489 | 73925 | -1.0768 | 0.0000 | |
| GSE63941 | ATP2A3 | 489 | 213036_x_at | 0.7773 | 0.2435 | |
| GSE77861 | ATP2A3 | 489 | 213036_x_at | 0.1549 | 0.4335 | |
| GSE97050 | ATP2A3 | 489 | A_24_P202319 | -0.0561 | 0.8987 | |
| SRP007169 | ATP2A3 | 489 | RNAseq | 0.0314 | 0.9550 | |
| SRP008496 | ATP2A3 | 489 | RNAseq | -0.1549 | 0.6708 | |
| SRP064894 | ATP2A3 | 489 | RNAseq | -0.5583 | 0.1035 | |
| SRP133303 | ATP2A3 | 489 | RNAseq | -1.5528 | 0.0000 | |
| SRP159526 | ATP2A3 | 489 | RNAseq | -0.9360 | 0.1112 | |
| SRP193095 | ATP2A3 | 489 | RNAseq | -1.1188 | 0.0139 | |
| SRP219564 | ATP2A3 | 489 | RNAseq | -0.0507 | 0.9162 | |
| TCGA | ATP2A3 | 489 | RNAseq | -0.7808 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ATP2A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP2A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP2A3 | 489 | 5 | 3 | 22 | |
| GSE20123 | ATP2A3 | 489 | 5 | 4 | 21 | |
| GSE43470 | ATP2A3 | 489 | 1 | 6 | 36 | |
| GSE46452 | ATP2A3 | 489 | 34 | 1 | 24 | |
| GSE47630 | ATP2A3 | 489 | 7 | 1 | 32 | |
| GSE54993 | ATP2A3 | 489 | 4 | 3 | 63 | |
| GSE54994 | ATP2A3 | 489 | 5 | 9 | 39 | |
| GSE60625 | ATP2A3 | 489 | 4 | 0 | 7 | |
| GSE74703 | ATP2A3 | 489 | 1 | 3 | 32 | |
| GSE74704 | ATP2A3 | 489 | 3 | 2 | 15 | |
| TCGA | ATP2A3 | 489 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 53; Total Number of normals: 348.
Somatic mutations of ATP2A3:
Generating mutation plots.
Highly correlated genes for ATP2A3:
Showing top 20/603 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP2A3 | DACT2 | 0.735424 | 3 | 0 | 3 |
| ATP2A3 | ZNF721 | 0.733378 | 3 | 0 | 3 |
| ATP2A3 | KHNYN | 0.732205 | 3 | 0 | 3 |
| ATP2A3 | ORAI3 | 0.731976 | 3 | 0 | 3 |
| ATP2A3 | ZNF414 | 0.727778 | 3 | 0 | 3 |
| ATP2A3 | TAGAP | 0.727229 | 4 | 0 | 4 |
| ATP2A3 | SLFN11 | 0.725806 | 3 | 0 | 3 |
| ATP2A3 | IL16 | 0.725754 | 5 | 0 | 5 |
| ATP2A3 | PKN1 | 0.720772 | 5 | 0 | 4 |
| ATP2A3 | SSBP4 | 0.72069 | 3 | 0 | 3 |
| ATP2A3 | PIGS | 0.7189 | 4 | 0 | 3 |
| ATP2A3 | RCSD1 | 0.71582 | 5 | 0 | 5 |
| ATP2A3 | GHDC | 0.714076 | 4 | 0 | 3 |
| ATP2A3 | DHRSX | 0.712996 | 3 | 0 | 3 |
| ATP2A3 | SETX | 0.712079 | 4 | 0 | 4 |
| ATP2A3 | ZBTB39 | 0.704314 | 4 | 0 | 4 |
| ATP2A3 | TMEM200C | 0.70395 | 3 | 0 | 3 |
| ATP2A3 | C16orf54 | 0.701494 | 5 | 0 | 5 |
| ATP2A3 | CLCN7 | 0.700491 | 3 | 0 | 3 |
| ATP2A3 | PRELID2 | 0.696739 | 3 | 0 | 3 |
For details and further investigation, click here
