| Full name: ubiquitin-fold modifier conjugating enzyme 1 | Alias Symbol: HSPC155 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 51506 | HGNC ID: HGNC:26941 | Ensembl Gene: ENSG00000143222 | OMIM ID: 610554 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UFC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UFC1 | 51506 | 217797_at | -0.2584 | 0.5302 | |
| GSE20347 | UFC1 | 51506 | 217797_at | -0.5409 | 0.0007 | |
| GSE23400 | UFC1 | 51506 | 217797_at | -0.3131 | 0.0000 | |
| GSE26886 | UFC1 | 51506 | 217797_at | -0.3600 | 0.1852 | |
| GSE29001 | UFC1 | 51506 | 217797_at | -0.6703 | 0.1666 | |
| GSE38129 | UFC1 | 51506 | 217797_at | -0.3498 | 0.0063 | |
| GSE45670 | UFC1 | 51506 | 217797_at | -0.3703 | 0.0055 | |
| GSE53622 | UFC1 | 51506 | 44986 | -0.2427 | 0.0000 | |
| GSE53624 | UFC1 | 51506 | 44986 | -0.4332 | 0.0000 | |
| GSE63941 | UFC1 | 51506 | 217797_at | -0.1366 | 0.7738 | |
| GSE77861 | UFC1 | 51506 | 217797_at | -0.3457 | 0.1446 | |
| GSE97050 | UFC1 | 51506 | A_23_P103905 | -0.2504 | 0.3381 | |
| SRP007169 | UFC1 | 51506 | RNAseq | -1.8345 | 0.0000 | |
| SRP008496 | UFC1 | 51506 | RNAseq | -1.4147 | 0.0000 | |
| SRP064894 | UFC1 | 51506 | RNAseq | -0.4703 | 0.0366 | |
| SRP133303 | UFC1 | 51506 | RNAseq | -0.3688 | 0.0157 | |
| SRP159526 | UFC1 | 51506 | RNAseq | -0.4407 | 0.1411 | |
| SRP193095 | UFC1 | 51506 | RNAseq | -0.9054 | 0.0000 | |
| SRP219564 | UFC1 | 51506 | RNAseq | -0.5140 | 0.0843 | |
| TCGA | UFC1 | 51506 | RNAseq | -0.1133 | 0.0474 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by UFC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UFC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UFC1 | 51506 | 10 | 0 | 20 | |
| GSE20123 | UFC1 | 51506 | 10 | 0 | 20 | |
| GSE43470 | UFC1 | 51506 | 7 | 2 | 34 | |
| GSE46452 | UFC1 | 51506 | 2 | 1 | 56 | |
| GSE47630 | UFC1 | 51506 | 14 | 0 | 26 | |
| GSE54993 | UFC1 | 51506 | 0 | 6 | 64 | |
| GSE54994 | UFC1 | 51506 | 16 | 0 | 37 | |
| GSE60625 | UFC1 | 51506 | 0 | 0 | 11 | |
| GSE74703 | UFC1 | 51506 | 7 | 2 | 27 | |
| GSE74704 | UFC1 | 51506 | 4 | 0 | 16 | |
| TCGA | UFC1 | 51506 | 45 | 3 | 48 |
Total number of gains: 115; Total number of losses: 14; Total Number of normals: 359.
Somatic mutations of UFC1:
Generating mutation plots.
Highly correlated genes for UFC1:
Showing top 20/1000 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UFC1 | TRAPPC2L | 0.774803 | 4 | 0 | 4 |
| UFC1 | CUL1 | 0.760442 | 3 | 0 | 3 |
| UFC1 | SEC22B | 0.75193 | 3 | 0 | 3 |
| UFC1 | IKZF5 | 0.737943 | 3 | 0 | 3 |
| UFC1 | FBXO8 | 0.732197 | 5 | 0 | 5 |
| UFC1 | MACROD2 | 0.726454 | 3 | 0 | 3 |
| UFC1 | ARID1A | 0.725764 | 3 | 0 | 3 |
| UFC1 | STK19 | 0.719591 | 6 | 0 | 5 |
| UFC1 | CNOT6 | 0.718993 | 3 | 0 | 3 |
| UFC1 | AZIN1 | 0.715984 | 3 | 0 | 3 |
| UFC1 | SPA17 | 0.715961 | 3 | 0 | 3 |
| UFC1 | NIPSNAP3A | 0.715582 | 5 | 0 | 4 |
| UFC1 | ORAI3 | 0.713225 | 3 | 0 | 3 |
| UFC1 | HOXA4 | 0.708391 | 3 | 0 | 3 |
| UFC1 | CCNYL1 | 0.69943 | 3 | 0 | 3 |
| UFC1 | POLR2L | 0.698737 | 4 | 0 | 3 |
| UFC1 | DLD | 0.698182 | 4 | 0 | 3 |
| UFC1 | PTAR1 | 0.695398 | 3 | 0 | 3 |
| UFC1 | SCOC | 0.69428 | 4 | 0 | 3 |
| UFC1 | HEIH | 0.693838 | 3 | 0 | 3 |
For details and further investigation, click here
