SMAD4

 

Full name: SMAD family member 4 Alias Symbol: DPC4
Type: protein-coding gene Cytoband: 18q21.2
Entrez ID: 4089 HGNC ID: HGNC:6770 Ensembl Gene: ENSG00000141646 OMIM ID: 600993
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 22/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SMAD4 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia

 

Expression of SMAD4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMAD4 4089 202527_s_at -0.5406 0.3932
GSE20347 SMAD4 4089 202527_s_at 0.2483 0.2665
GSE23400 SMAD4 4089 202527_s_at 0.3396 0.0021
GSE26886 SMAD4 4089 235725_at 0.2248 0.2548
GSE29001 SMAD4 4089 202527_s_at 0.0368 0.9018
GSE38129 SMAD4 4089 202527_s_at 0.2278 0.1938
GSE45670 SMAD4 4089 202527_s_at -0.4045 0.0083
GSE53622 SMAD4 4089 545 -0.2794 0.0001
GSE53624 SMAD4 4089 545 -0.0912 0.2229
GSE63941 SMAD4 4089 202527_s_at -1.0495 0.1912
GSE77861 SMAD4 4089 235725_at 0.1527 0.3401
GSE97050 SMAD4 A_19_P00804817 -0.8282 0.1049
SRP007169 SMAD4 4089 RNAseq 0.8121 0.0316
SRP008496 SMAD4 4089 RNAseq 1.4731 0.0003
SRP064894 SMAD4 4089 RNAseq -0.0978 0.5100
SRP133303 SMAD4 4089 RNAseq -0.1797 0.2047
SRP159526 SMAD4 4089 RNAseq -0.2308 0.3148
SRP193095 SMAD4 4089 RNAseq -0.1752 0.1038
SRP219564 SMAD4 4089 RNAseq -0.3292 0.2373
TCGA SMAD4 4089 RNAseq -0.2148 0.0001

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SMAD4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMAD4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMAD4 4089 1 9 20
GSE20123 SMAD4 4089 1 9 20
GSE43470 SMAD4 4089 0 4 39
GSE46452 SMAD4 4089 1 26 32
GSE47630 SMAD4 4089 5 20 15
GSE54993 SMAD4 4089 9 0 61
GSE54994 SMAD4 4089 1 17 35
GSE60625 SMAD4 4089 0 4 7
GSE74703 SMAD4 4089 0 4 32
GSE74704 SMAD4 4089 1 6 13
TCGA SMAD4 4089 8 45 43

Total number of gains: 27; Total number of losses: 144; Total Number of normals: 317.  

 

Somatic mutations of SMAD4:

 

Generating mutation plots.

 

Highly correlated genes for SMAD4:

 

Showing top 20/626 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMAD4DUSP30.778128303
SMAD4ORAI30.774985303
SMAD4RBPMS20.732535403
SMAD4HOXA40.727156303
SMAD4MAMDC20.726857404
SMAD4CASQ20.724743403
SMAD4IQUB0.718958303
SMAD4KIF5C0.718395404
SMAD4CGNL10.716486303
SMAD4NPY1R0.711402303
SMAD4ARL10.704167404
SMAD4FHL10.704089504
SMAD4SELENBP10.70376404
SMAD4RGMB0.703743403
SMAD4ZFAND50.701692403
SMAD4FNIP20.700589504
SMAD4MKLN10.695975505
SMAD4SLC2A130.692824303
SMAD4GRB20.69022303
SMAD4FLNA0.688518403

For details and further investigation, click here