| Full name: oxytocin receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 5021 | HGNC ID: HGNC:8529 | Ensembl Gene: ENSG00000180914 | OMIM ID: 167055 |
| Drug and gene relationship at DGIdb | |||
OXTR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04921 | Oxytocin signaling pathway |
Expression of OXTR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OXTR | 5021 | 206825_at | -0.9412 | 0.4715 | |
| GSE20347 | OXTR | 5021 | 206825_at | 0.1546 | 0.0902 | |
| GSE23400 | OXTR | 5021 | 206825_at | -0.0986 | 0.0371 | |
| GSE26886 | OXTR | 5021 | 206825_at | 0.5929 | 0.0176 | |
| GSE29001 | OXTR | 5021 | 206825_at | 0.2151 | 0.1855 | |
| GSE38129 | OXTR | 5021 | 206825_at | 0.1945 | 0.1031 | |
| GSE45670 | OXTR | 5021 | 206825_at | 0.2767 | 0.2324 | |
| GSE53622 | OXTR | 5021 | 94668 | 0.3757 | 0.0067 | |
| GSE53624 | OXTR | 5021 | 94668 | 0.4751 | 0.0006 | |
| GSE63941 | OXTR | 5021 | 206825_at | -2.4946 | 0.0166 | |
| GSE77861 | OXTR | 5021 | 206825_at | -0.1330 | 0.2912 | |
| GSE97050 | OXTR | 5021 | A_33_P3413741 | 0.0280 | 0.9051 | |
| SRP007169 | OXTR | 5021 | RNAseq | 2.2100 | 0.0254 | |
| SRP064894 | OXTR | 5021 | RNAseq | -0.0622 | 0.8692 | |
| SRP133303 | OXTR | 5021 | RNAseq | 0.5418 | 0.0005 | |
| SRP159526 | OXTR | 5021 | RNAseq | -1.2910 | 0.1337 | |
| SRP193095 | OXTR | 5021 | RNAseq | 0.3761 | 0.0046 | |
| SRP219564 | OXTR | 5021 | RNAseq | 0.7480 | 0.2094 | |
| TCGA | OXTR | 5021 | RNAseq | 0.4594 | 0.0649 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by OXTR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OXTR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OXTR | 5021 | 1 | 18 | 11 | |
| GSE20123 | OXTR | 5021 | 1 | 18 | 11 | |
| GSE43470 | OXTR | 5021 | 0 | 20 | 23 | |
| GSE46452 | OXTR | 5021 | 2 | 17 | 40 | |
| GSE47630 | OXTR | 5021 | 1 | 23 | 16 | |
| GSE54993 | OXTR | 5021 | 6 | 1 | 63 | |
| GSE54994 | OXTR | 5021 | 3 | 31 | 19 | |
| GSE60625 | OXTR | 5021 | 5 | 0 | 6 | |
| GSE74703 | OXTR | 5021 | 0 | 17 | 19 | |
| GSE74704 | OXTR | 5021 | 1 | 11 | 8 | |
| TCGA | OXTR | 5021 | 5 | 65 | 26 |
Total number of gains: 25; Total number of losses: 221; Total Number of normals: 242.
Somatic mutations of OXTR:
Generating mutation plots.
Highly correlated genes for OXTR:
Showing top 20/269 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OXTR | GRIA4 | 0.753868 | 3 | 0 | 3 |
| OXTR | LINC00276 | 0.74125 | 3 | 0 | 3 |
| OXTR | SLC26A5 | 0.733363 | 3 | 0 | 3 |
| OXTR | SLC25A53 | 0.730596 | 3 | 0 | 3 |
| OXTR | OR2AT4 | 0.726054 | 3 | 0 | 3 |
| OXTR | ZBTB46-AS1 | 0.723555 | 3 | 0 | 3 |
| OXTR | ALG11 | 0.716884 | 3 | 0 | 3 |
| OXTR | ARL17A | 0.710811 | 3 | 0 | 3 |
| OXTR | BFSP2-AS1 | 0.707686 | 3 | 0 | 3 |
| OXTR | CD200 | 0.702624 | 3 | 0 | 3 |
| OXTR | C22orf31 | 0.696669 | 3 | 0 | 3 |
| OXTR | OR2T33 | 0.695926 | 4 | 0 | 3 |
| OXTR | CRIP1 | 0.695251 | 3 | 0 | 3 |
| OXTR | PDHA2 | 0.693097 | 3 | 0 | 3 |
| OXTR | CELA3A | 0.692113 | 3 | 0 | 3 |
| OXTR | GFAP | 0.685811 | 3 | 0 | 3 |
| OXTR | KCNJ9 | 0.675835 | 4 | 0 | 3 |
| OXTR | PTGER2 | 0.673266 | 5 | 0 | 4 |
| OXTR | ADCY9 | 0.671335 | 3 | 0 | 3 |
| OXTR | MAP4 | 0.670225 | 5 | 0 | 4 |
For details and further investigation, click here
