| Full name: p21 (RAC1) activated kinase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 10298 | HGNC ID: HGNC:16059 | Ensembl Gene: ENSG00000130669 | OMIM ID: 605451 |
| Drug and gene relationship at DGIdb | |||
PAK4 involved pathways:
Expression of PAK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAK4 | 10298 | 203154_s_at | 0.0164 | 0.9755 | |
| GSE20347 | PAK4 | 10298 | 203154_s_at | -0.1204 | 0.4614 | |
| GSE23400 | PAK4 | 10298 | 203154_s_at | -0.1234 | 0.0141 | |
| GSE26886 | PAK4 | 10298 | 203154_s_at | 0.2211 | 0.2510 | |
| GSE29001 | PAK4 | 10298 | 203154_s_at | -0.4250 | 0.0612 | |
| GSE38129 | PAK4 | 10298 | 203154_s_at | -0.0026 | 0.9869 | |
| GSE45670 | PAK4 | 10298 | 203154_s_at | 0.0306 | 0.7775 | |
| GSE53622 | PAK4 | 10298 | 156444 | 0.0275 | 0.7599 | |
| GSE53624 | PAK4 | 10298 | 128396 | -0.0259 | 0.6925 | |
| GSE63941 | PAK4 | 10298 | 203154_s_at | 1.3132 | 0.0000 | |
| GSE77861 | PAK4 | 10298 | 203154_s_at | 0.1117 | 0.6384 | |
| GSE97050 | PAK4 | 10298 | A_24_P313822 | 0.2585 | 0.4133 | |
| SRP007169 | PAK4 | 10298 | RNAseq | 0.5211 | 0.3498 | |
| SRP008496 | PAK4 | 10298 | RNAseq | -0.3042 | 0.4425 | |
| SRP064894 | PAK4 | 10298 | RNAseq | -0.0446 | 0.8621 | |
| SRP133303 | PAK4 | 10298 | RNAseq | 0.0729 | 0.6926 | |
| SRP159526 | PAK4 | 10298 | RNAseq | 0.2596 | 0.2881 | |
| SRP193095 | PAK4 | 10298 | RNAseq | -0.2164 | 0.0762 | |
| SRP219564 | PAK4 | 10298 | RNAseq | -0.2803 | 0.4841 | |
| TCGA | PAK4 | 10298 | RNAseq | 0.0735 | 0.1242 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PAK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAK4 | 10298 | 7 | 4 | 19 | |
| GSE20123 | PAK4 | 10298 | 7 | 3 | 20 | |
| GSE43470 | PAK4 | 10298 | 4 | 11 | 28 | |
| GSE46452 | PAK4 | 10298 | 47 | 2 | 10 | |
| GSE47630 | PAK4 | 10298 | 9 | 5 | 26 | |
| GSE54993 | PAK4 | 10298 | 17 | 3 | 50 | |
| GSE54994 | PAK4 | 10298 | 7 | 10 | 36 | |
| GSE60625 | PAK4 | 10298 | 9 | 0 | 2 | |
| GSE74703 | PAK4 | 10298 | 4 | 7 | 25 | |
| GSE74704 | PAK4 | 10298 | 7 | 1 | 12 | |
| TCGA | PAK4 | 10298 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 62; Total Number of normals: 294.
Somatic mutations of PAK4:
Generating mutation plots.
Highly correlated genes for PAK4:
Showing top 20/272 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAK4 | NEUROD6 | 0.676533 | 3 | 0 | 3 |
| PAK4 | VIPR1 | 0.652626 | 3 | 0 | 3 |
| PAK4 | TMEM214 | 0.635718 | 4 | 0 | 3 |
| PAK4 | GPSM3 | 0.635342 | 3 | 0 | 3 |
| PAK4 | GATAD2B | 0.635212 | 3 | 0 | 3 |
| PAK4 | SUGP1 | 0.634652 | 4 | 0 | 3 |
| PAK4 | HCN3 | 0.62379 | 4 | 0 | 3 |
| PAK4 | KDM8 | 0.619299 | 3 | 0 | 3 |
| PAK4 | WAS | 0.618892 | 3 | 0 | 3 |
| PAK4 | FBXO27 | 0.618839 | 6 | 0 | 5 |
| PAK4 | UNC13D | 0.617172 | 4 | 0 | 4 |
| PAK4 | DEF6 | 0.610806 | 5 | 0 | 3 |
| PAK4 | LSR | 0.607024 | 8 | 0 | 7 |
| PAK4 | CAMSAP3 | 0.606201 | 5 | 0 | 5 |
| PAK4 | OPHN1 | 0.604424 | 5 | 0 | 4 |
| PAK4 | ITPKC | 0.603058 | 5 | 0 | 4 |
| PAK4 | CCDC114 | 0.601176 | 3 | 0 | 3 |
| PAK4 | MCRS1 | 0.598661 | 4 | 0 | 3 |
| PAK4 | TRAPPC1 | 0.597962 | 5 | 0 | 3 |
| PAK4 | ACTN4 | 0.597262 | 13 | 0 | 9 |
For details and further investigation, click here
