| Full name: actinin alpha 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 81 | HGNC ID: HGNC:166 | Ensembl Gene: ENSG00000130402 | OMIM ID: 604638 |
| Drug and gene relationship at DGIdb | |||
ACTN4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04520 | Adherens junction | |
| hsa04530 | Tight junction | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ACTN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTN4 | 81 | 200601_at | -0.3014 | 0.5160 | |
| GSE20347 | ACTN4 | 81 | 200601_at | -0.2726 | 0.2087 | |
| GSE23400 | ACTN4 | 81 | 200601_at | -0.2454 | 0.0047 | |
| GSE26886 | ACTN4 | 81 | 200601_at | 0.2095 | 0.3692 | |
| GSE29001 | ACTN4 | 81 | 200601_at | -0.3993 | 0.3516 | |
| GSE38129 | ACTN4 | 81 | 200601_at | -0.0667 | 0.6712 | |
| GSE45670 | ACTN4 | 81 | 200601_at | -0.2224 | 0.0316 | |
| GSE53622 | ACTN4 | 81 | 80626 | -0.6189 | 0.0000 | |
| GSE53624 | ACTN4 | 81 | 80626 | -0.5201 | 0.0000 | |
| GSE63941 | ACTN4 | 81 | 200601_at | 0.5250 | 0.2440 | |
| GSE77861 | ACTN4 | 81 | 200601_at | 0.2679 | 0.3904 | |
| GSE97050 | ACTN4 | 81 | A_23_P101655 | -0.2665 | 0.4466 | |
| SRP007169 | ACTN4 | 81 | RNAseq | -0.7894 | 0.1224 | |
| SRP008496 | ACTN4 | 81 | RNAseq | -1.0715 | 0.0025 | |
| SRP064894 | ACTN4 | 81 | RNAseq | -0.5828 | 0.0013 | |
| SRP133303 | ACTN4 | 81 | RNAseq | -0.3667 | 0.1296 | |
| SRP159526 | ACTN4 | 81 | RNAseq | -0.2643 | 0.3547 | |
| SRP193095 | ACTN4 | 81 | RNAseq | -0.3838 | 0.0072 | |
| SRP219564 | ACTN4 | 81 | RNAseq | -0.5707 | 0.0389 | |
| TCGA | ACTN4 | 81 | RNAseq | 0.0354 | 0.3463 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACTN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACTN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTN4 | 81 | 7 | 4 | 19 | |
| GSE20123 | ACTN4 | 81 | 7 | 3 | 20 | |
| GSE43470 | ACTN4 | 81 | 4 | 10 | 29 | |
| GSE46452 | ACTN4 | 81 | 47 | 2 | 10 | |
| GSE47630 | ACTN4 | 81 | 9 | 5 | 26 | |
| GSE54993 | ACTN4 | 81 | 17 | 3 | 50 | |
| GSE54994 | ACTN4 | 81 | 6 | 9 | 38 | |
| GSE60625 | ACTN4 | 81 | 9 | 0 | 2 | |
| GSE74703 | ACTN4 | 81 | 4 | 6 | 26 | |
| GSE74704 | ACTN4 | 81 | 7 | 1 | 12 | |
| TCGA | ACTN4 | 81 | 16 | 15 | 65 |
Total number of gains: 133; Total number of losses: 58; Total Number of normals: 297.
Somatic mutations of ACTN4:
Generating mutation plots.
Highly correlated genes for ACTN4:
Showing top 20/351 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTN4 | PIAS3 | 0.659978 | 3 | 0 | 3 |
| ACTN4 | EID2 | 0.657516 | 4 | 0 | 4 |
| ACTN4 | UPK3B | 0.654469 | 3 | 0 | 3 |
| ACTN4 | KRT78 | 0.653957 | 5 | 0 | 4 |
| ACTN4 | DMPK | 0.652415 | 4 | 0 | 4 |
| ACTN4 | GGT6 | 0.652329 | 4 | 0 | 3 |
| ACTN4 | SLC46A2 | 0.651192 | 4 | 0 | 4 |
| ACTN4 | KAZN | 0.650115 | 9 | 0 | 8 |
| ACTN4 | EPGN | 0.648141 | 3 | 0 | 3 |
| ACTN4 | WDR26 | 0.646347 | 4 | 0 | 4 |
| ACTN4 | PHLDB3 | 0.642245 | 4 | 0 | 4 |
| ACTN4 | USF2 | 0.63584 | 7 | 0 | 6 |
| ACTN4 | PERM1 | 0.633718 | 3 | 0 | 3 |
| ACTN4 | CPEB4 | 0.633166 | 4 | 0 | 4 |
| ACTN4 | CTNND1 | 0.632755 | 3 | 0 | 3 |
| ACTN4 | PLEKHN1 | 0.632328 | 5 | 0 | 4 |
| ACTN4 | TMEM79 | 0.625 | 5 | 0 | 4 |
| ACTN4 | CRISP2 | 0.620141 | 5 | 0 | 4 |
| ACTN4 | RMND5B | 0.619137 | 5 | 0 | 4 |
| ACTN4 | CASKIN2 | 0.611773 | 3 | 0 | 3 |
For details and further investigation, click here
