| Full name: unc-13 homolog D | Alias Symbol: Munc13-4 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 201294 | HGNC ID: HGNC:23147 | Ensembl Gene: ENSG00000092929 | OMIM ID: 608897 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UNC13D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC13D | 201294 | 226678_at | -0.1678 | 0.6021 | |
| GSE26886 | UNC13D | 201294 | 226678_at | -0.2343 | 0.1889 | |
| GSE45670 | UNC13D | 201294 | 226678_at | 0.0752 | 0.5644 | |
| GSE53622 | UNC13D | 201294 | 167331 | -0.8552 | 0.0000 | |
| GSE53624 | UNC13D | 201294 | 167331 | -0.8673 | 0.0000 | |
| GSE63941 | UNC13D | 201294 | 226678_at | 0.5371 | 0.0911 | |
| GSE77861 | UNC13D | 201294 | 226678_at | -0.2484 | 0.0736 | |
| GSE97050 | UNC13D | 201294 | A_24_P53215 | 0.1279 | 0.5817 | |
| SRP007169 | UNC13D | 201294 | RNAseq | -1.9460 | 0.0010 | |
| SRP008496 | UNC13D | 201294 | RNAseq | -2.6683 | 0.0000 | |
| SRP064894 | UNC13D | 201294 | RNAseq | -0.8319 | 0.0002 | |
| SRP133303 | UNC13D | 201294 | RNAseq | -0.7172 | 0.0212 | |
| SRP159526 | UNC13D | 201294 | RNAseq | -2.1393 | 0.0000 | |
| SRP193095 | UNC13D | 201294 | RNAseq | -0.7460 | 0.0006 | |
| SRP219564 | UNC13D | 201294 | RNAseq | -1.1028 | 0.0345 | |
| TCGA | UNC13D | 201294 | RNAseq | -0.1477 | 0.2952 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by UNC13D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC13D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC13D | 201294 | 7 | 2 | 21 | |
| GSE20123 | UNC13D | 201294 | 7 | 2 | 21 | |
| GSE43470 | UNC13D | 201294 | 5 | 3 | 35 | |
| GSE46452 | UNC13D | 201294 | 34 | 0 | 25 | |
| GSE47630 | UNC13D | 201294 | 8 | 1 | 31 | |
| GSE54993 | UNC13D | 201294 | 2 | 5 | 63 | |
| GSE54994 | UNC13D | 201294 | 10 | 4 | 39 | |
| GSE60625 | UNC13D | 201294 | 6 | 0 | 5 | |
| GSE74703 | UNC13D | 201294 | 5 | 1 | 30 | |
| GSE74704 | UNC13D | 201294 | 5 | 1 | 14 | |
| TCGA | UNC13D | 201294 | 32 | 9 | 55 |
Total number of gains: 121; Total number of losses: 28; Total Number of normals: 339.
Somatic mutations of UNC13D:
Generating mutation plots.
Highly correlated genes for UNC13D:
Showing top 20/721 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC13D | LRBA | 0.749173 | 3 | 0 | 3 |
| UNC13D | AP1M2 | 0.717489 | 3 | 0 | 3 |
| UNC13D | ARHGEF5 | 0.715497 | 3 | 0 | 3 |
| UNC13D | TMEM38A | 0.708964 | 3 | 0 | 3 |
| UNC13D | LACTBL1 | 0.704465 | 3 | 0 | 3 |
| UNC13D | SLC35F6 | 0.700979 | 4 | 0 | 4 |
| UNC13D | RIPK3 | 0.699658 | 4 | 0 | 4 |
| UNC13D | DCXR | 0.692981 | 4 | 0 | 4 |
| UNC13D | AP1G2 | 0.691305 | 5 | 0 | 4 |
| UNC13D | ACOT11 | 0.690396 | 4 | 0 | 4 |
| UNC13D | SYTL1 | 0.682061 | 6 | 0 | 6 |
| UNC13D | DDI2 | 0.67924 | 3 | 0 | 3 |
| UNC13D | HSH2D | 0.674565 | 3 | 0 | 3 |
| UNC13D | TSPO | 0.672998 | 5 | 0 | 5 |
| UNC13D | TAS1R2 | 0.672128 | 3 | 0 | 3 |
| UNC13D | COMMD8 | 0.669278 | 3 | 0 | 3 |
| UNC13D | SLC50A1 | 0.66915 | 3 | 0 | 3 |
| UNC13D | NAAA | 0.668904 | 3 | 0 | 3 |
| UNC13D | FAM214B | 0.668842 | 6 | 0 | 6 |
| UNC13D | ITPRIP | 0.668706 | 6 | 0 | 6 |
For details and further investigation, click here
