| Full name: microspherule protein 1 | Alias Symbol: ICP22BP|MSP58|P78|MCRS2|INO80Q | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 10445 | HGNC ID: HGNC:6960 | Ensembl Gene: ENSG00000187778 | OMIM ID: 609504 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MCRS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCRS1 | 10445 | 202556_s_at | 0.2585 | 0.4898 | |
| GSE20347 | MCRS1 | 10445 | 202556_s_at | -0.0570 | 0.6488 | |
| GSE23400 | MCRS1 | 10445 | 202556_s_at | 0.0127 | 0.7875 | |
| GSE26886 | MCRS1 | 10445 | 202556_s_at | -0.8182 | 0.0031 | |
| GSE29001 | MCRS1 | 10445 | 202556_s_at | -0.0625 | 0.8245 | |
| GSE38129 | MCRS1 | 10445 | 202556_s_at | 0.0643 | 0.4905 | |
| GSE45670 | MCRS1 | 10445 | 202556_s_at | -0.0027 | 0.9839 | |
| GSE53622 | MCRS1 | 10445 | 58309 | 0.0644 | 0.3018 | |
| GSE53624 | MCRS1 | 10445 | 58309 | 0.1070 | 0.1171 | |
| GSE63941 | MCRS1 | 10445 | 202556_s_at | 1.4675 | 0.0001 | |
| GSE77861 | MCRS1 | 10445 | 202556_s_at | 0.0246 | 0.9134 | |
| GSE97050 | MCRS1 | 10445 | A_23_P48237 | 0.1231 | 0.8715 | |
| SRP007169 | MCRS1 | 10445 | RNAseq | -0.5129 | 0.1628 | |
| SRP008496 | MCRS1 | 10445 | RNAseq | -0.4802 | 0.0300 | |
| SRP064894 | MCRS1 | 10445 | RNAseq | 0.2035 | 0.3086 | |
| SRP133303 | MCRS1 | 10445 | RNAseq | 0.1060 | 0.5137 | |
| SRP159526 | MCRS1 | 10445 | RNAseq | -0.0871 | 0.6612 | |
| SRP193095 | MCRS1 | 10445 | RNAseq | -0.1184 | 0.1075 | |
| SRP219564 | MCRS1 | 10445 | RNAseq | 0.0736 | 0.8046 | |
| TCGA | MCRS1 | 10445 | RNAseq | -0.0011 | 0.9819 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MCRS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCRS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCRS1 | 10445 | 7 | 1 | 22 | |
| GSE20123 | MCRS1 | 10445 | 7 | 1 | 22 | |
| GSE43470 | MCRS1 | 10445 | 3 | 1 | 39 | |
| GSE46452 | MCRS1 | 10445 | 8 | 1 | 50 | |
| GSE47630 | MCRS1 | 10445 | 11 | 2 | 27 | |
| GSE54993 | MCRS1 | 10445 | 0 | 5 | 65 | |
| GSE54994 | MCRS1 | 10445 | 4 | 1 | 48 | |
| GSE60625 | MCRS1 | 10445 | 0 | 0 | 11 | |
| GSE74703 | MCRS1 | 10445 | 3 | 1 | 32 | |
| GSE74704 | MCRS1 | 10445 | 5 | 1 | 14 | |
| TCGA | MCRS1 | 10445 | 16 | 11 | 69 |
Total number of gains: 64; Total number of losses: 25; Total Number of normals: 399.
Somatic mutations of MCRS1:
Generating mutation plots.
Highly correlated genes for MCRS1:
Showing top 20/225 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCRS1 | VAMP8 | 0.694853 | 3 | 0 | 3 |
| MCRS1 | UBL7 | 0.693996 | 6 | 0 | 5 |
| MCRS1 | SLC9A3R1 | 0.691242 | 3 | 0 | 3 |
| MCRS1 | NDUFS3 | 0.679384 | 4 | 0 | 3 |
| MCRS1 | ANAPC11 | 0.67748 | 3 | 0 | 3 |
| MCRS1 | PPP2R1A | 0.672598 | 5 | 0 | 4 |
| MCRS1 | TRIM26 | 0.668165 | 3 | 0 | 3 |
| MCRS1 | SOX13 | 0.668147 | 4 | 0 | 3 |
| MCRS1 | WNK2 | 0.666838 | 3 | 0 | 3 |
| MCRS1 | NAPA | 0.661873 | 3 | 0 | 3 |
| MCRS1 | SPRYD4 | 0.659108 | 4 | 0 | 3 |
| MCRS1 | TECR | 0.657905 | 4 | 0 | 4 |
| MCRS1 | PLK1 | 0.657815 | 3 | 0 | 3 |
| MCRS1 | ACO2 | 0.657653 | 3 | 0 | 3 |
| MCRS1 | RPL8 | 0.654235 | 4 | 0 | 3 |
| MCRS1 | TMEM109 | 0.650502 | 3 | 0 | 3 |
| MCRS1 | ETNK2 | 0.646044 | 3 | 0 | 3 |
| MCRS1 | KRT5 | 0.639015 | 3 | 0 | 3 |
| MCRS1 | PABPC4L | 0.638468 | 3 | 0 | 3 |
| MCRS1 | LARP4 | 0.635198 | 5 | 0 | 5 |
For details and further investigation, click here
