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Multi-Omics Database of ESCC

 

PCDH18

 

Full name: protocadherin 18 Alias Symbol: KIAA1562|PCDH68L
Type: protein-coding gene Cytoband: 4q28.3
Entrez ID: 54510 HGNC ID: HGNC:14268 Ensembl Gene: ENSG00000189184 OMIM ID: 608287
Drug and gene relationship at DGIdb

 

Expression of PCDH18:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PCDH18 54510 225975_at -0.7441 0.2884
GSE26886 PCDH18 54510 225975_at 0.4234 0.2843
GSE45670 PCDH18 54510 225975_at -1.0897 0.0160
GSE53622 PCDH18 54510 21842 -0.3174 0.0388
GSE53624 PCDH18 54510 21842 -0.1874 0.3117
GSE63941 PCDH18 54510 225975_at -7.2363 0.0000
GSE77861 PCDH18 54510 225975_at 0.6122 0.0332
GSE97050 PCDH18 54510 A_33_P3225760 -0.6667 0.1210
SRP007169 PCDH18 54510 RNAseq 1.5194 0.0010
SRP008496 PCDH18 54510 RNAseq 1.5750 0.0001
SRP064894 PCDH18 54510 RNAseq -0.0090 0.9774
SRP133303 PCDH18 54510 RNAseq -0.3804 0.2162
SRP159526 PCDH18 54510 RNAseq 0.3696 0.4042
SRP193095 PCDH18 54510 RNAseq 0.6718 0.0364
SRP219564 PCDH18 54510 RNAseq -0.3731 0.5419
TCGA PCDH18 54510 RNAseq -0.1560 0.2574

Upregulated datasets: 2; Downregulated datasets: 2.  

 

Survival by PCDH18 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PCDH18:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PCDH18 54510 0 12 18
GSE20123 PCDH18 54510 0 12 18
GSE43470 PCDH18 54510 0 13 30
GSE46452 PCDH18 54510 1 36 22
GSE47630 PCDH18 54510 0 22 18
GSE54993 PCDH18 54510 10 0 60
GSE54994 PCDH18 54510 2 10 41
GSE60625 PCDH18 54510 0 1 10
GSE74703 PCDH18 54510 0 11 25
GSE74704 PCDH18 54510 0 6 14
TCGA PCDH18 54510 10 32 54

Total number of gains: 23; Total number of losses: 155; Total Number of normals: 310.  

 

Somatic mutations of PCDH18:

 

Generating mutation plots.

 

Highly correlated genes for PCDH18:

 

Showing top 20/988 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PCDH18KLF70.83043303
PCDH18CXCL50.823343303
PCDH18SGTB0.797402404
PCDH18C20orf1940.792561303
PCDH18FAM50A0.773832303
PCDH18KRT33B0.772481303
PCDH18KIAA03550.768158303
PCDH18DUSP60.761966303
PCDH18TCEAL60.757627303
PCDH18EHD20.756445303
PCDH18CYYR10.755917504
PCDH18PRPS10.752969303
PCDH18YLPM10.752509303
PCDH18NR2F10.751289303
PCDH18TNFSF120.750467303
PCDH18MRC20.749275303
PCDH18CD99L20.748861404
PCDH18PEG30.748685404
PCDH18SLC15A40.747233303
PCDH18FGFR10.745527605

For details and further investigation, click here