FGFR1

 

Full name: fibroblast growth factor receptor 1 Alias Symbol: H2|H3|H4|H5|CEK|FLG|BFGFR|N-SAM|CD331
Type: protein-coding gene Cytoband: 8p11.23
Entrez ID: 2260 HGNC ID: HGNC:3688 Ensembl Gene: ENSG00000077782 OMIM ID: 136350
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 13/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

FGFR1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04520Adherens junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05215Prostate cancer
hsa05218Melanoma

 

Expression of FGFR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGFR1 2260 211535_s_at -0.8116 0.1684
GSE20347 FGFR1 2260 215404_x_at 0.3270 0.1141
GSE23400 FGFR1 2260 210973_s_at -0.2323 0.0010
GSE26886 FGFR1 2260 215404_x_at 0.3287 0.0747
GSE29001 FGFR1 2260 215404_x_at 0.1396 0.5400
GSE38129 FGFR1 2260 211535_s_at 0.0075 0.9851
GSE45670 FGFR1 2260 215404_x_at 0.2468 0.0474
GSE53622 FGFR1 2260 35412 -0.3684 0.0435
GSE53624 FGFR1 2260 35412 -0.1762 0.1466
GSE63941 FGFR1 2260 211535_s_at -3.8622 0.0000
GSE77861 FGFR1 2260 207937_x_at 0.0939 0.4071
GSE97050 FGFR1 2260 A_23_P372923 -0.7182 0.2104
SRP007169 FGFR1 2260 RNAseq 2.0355 0.0007
SRP008496 FGFR1 2260 RNAseq 2.2483 0.0000
SRP064894 FGFR1 2260 RNAseq -0.4066 0.2363
SRP133303 FGFR1 2260 RNAseq 0.3536 0.3539
SRP193095 FGFR1 2260 RNAseq 1.4188 0.0000
SRP219564 FGFR1 2260 RNAseq -0.3909 0.6203
TCGA FGFR1 2260 RNAseq -0.3420 0.0096

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by FGFR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FGFR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGFR1 2260 10 4 16
GSE20123 FGFR1 2260 11 4 15
GSE43470 FGFR1 2260 8 6 29
GSE46452 FGFR1 2260 21 5 33
GSE47630 FGFR1 2260 12 7 21
GSE54993 FGFR1 2260 2 16 52
GSE54994 FGFR1 2260 17 7 29
GSE60625 FGFR1 2260 3 0 8
GSE74703 FGFR1 2260 8 5 23
GSE74704 FGFR1 2260 9 1 10
TCGA FGFR1 2260 37 21 38

Total number of gains: 138; Total number of losses: 76; Total Number of normals: 274.  

 

Somatic mutations of FGFR1:

 

Generating mutation plots.

 

Highly correlated genes for FGFR1:

 

Showing top 20/735 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGFR1KLHL240.841672505
FGFR1ACO10.814309404
FGFR1ALMS10.810363605
FGFR1AFF30.789611404
FGFR1SLC2A130.781963303
FGFR1RSPH90.766971303
FGFR1ANKRD10-IT10.763392404
FGFR1FXYD60.762187606
FGFR1FAM161B0.761053404
FGFR1C11orf960.759757403
FGFR1IL13RA20.747158303
FGFR1PCDH180.745527605
FGFR1TAOK10.74542504
FGFR1SFTPB0.745313505
FGFR1LRCH20.744262505
FGFR1VEZT0.739833404
FGFR1CHRNG0.739616303
FGFR1TIMP30.739276504
FGFR1ZEB10.737184303
FGFR1IL11RA0.730972303

For details and further investigation, click here