| Full name: phosphoribosyl pyrophosphate synthetase 1 | Alias Symbol: CMTX5|DFNX1 | ||
| Type: protein-coding gene | Cytoband: Xq22.3 | ||
| Entrez ID: 5631 | HGNC ID: HGNC:9462 | Ensembl Gene: ENSG00000147224 | OMIM ID: 311850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PRPS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPS1 | 5631 | 209440_at | 0.3921 | 0.2870 | |
| GSE20347 | PRPS1 | 5631 | 209440_at | 1.0079 | 0.0000 | |
| GSE23400 | PRPS1 | 5631 | 209440_at | 0.6788 | 0.0000 | |
| GSE26886 | PRPS1 | 5631 | 209440_at | 1.7955 | 0.0000 | |
| GSE29001 | PRPS1 | 5631 | 209440_at | 0.8439 | 0.0079 | |
| GSE38129 | PRPS1 | 5631 | 209440_at | 0.9211 | 0.0000 | |
| GSE45670 | PRPS1 | 5631 | 209440_at | 0.5353 | 0.0158 | |
| GSE53622 | PRPS1 | 5631 | 23491 | 0.7059 | 0.0000 | |
| GSE53624 | PRPS1 | 5631 | 23491 | 0.7713 | 0.0000 | |
| GSE63941 | PRPS1 | 5631 | 209440_at | 0.0925 | 0.9041 | |
| GSE77861 | PRPS1 | 5631 | 209440_at | 1.0331 | 0.0005 | |
| GSE97050 | PRPS1 | 5631 | A_23_P95764 | 0.1093 | 0.6337 | |
| SRP007169 | PRPS1 | 5631 | RNAseq | 1.0828 | 0.0201 | |
| SRP008496 | PRPS1 | 5631 | RNAseq | 1.0352 | 0.0002 | |
| SRP064894 | PRPS1 | 5631 | RNAseq | 0.6082 | 0.0004 | |
| SRP133303 | PRPS1 | 5631 | RNAseq | 1.0451 | 0.0000 | |
| SRP159526 | PRPS1 | 5631 | RNAseq | 0.8328 | 0.0019 | |
| SRP193095 | PRPS1 | 5631 | RNAseq | 0.8274 | 0.0000 | |
| SRP219564 | PRPS1 | 5631 | RNAseq | 0.8128 | 0.0718 | |
| TCGA | PRPS1 | 5631 | RNAseq | 0.2002 | 0.0008 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by PRPS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPS1:
No record found for this gene.
Somatic mutations of PRPS1:
Generating mutation plots.
Highly correlated genes for PRPS1:
Showing top 20/2148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPS1 | CRTC2 | 0.809712 | 3 | 0 | 3 |
| PRPS1 | NEK3 | 0.792631 | 3 | 0 | 3 |
| PRPS1 | TMTC1 | 0.776901 | 4 | 0 | 4 |
| PRPS1 | WDR54 | 0.773221 | 7 | 0 | 7 |
| PRPS1 | WDR75 | 0.760261 | 4 | 0 | 4 |
| PRPS1 | PCDH18 | 0.752969 | 3 | 0 | 3 |
| PRPS1 | ARPC1B | 0.747958 | 11 | 0 | 11 |
| PRPS1 | CERS2 | 0.746802 | 9 | 0 | 9 |
| PRPS1 | SLC25A32 | 0.744835 | 11 | 0 | 10 |
| PRPS1 | C11orf49 | 0.738265 | 3 | 0 | 3 |
| PRPS1 | DMTF1 | 0.735292 | 3 | 0 | 3 |
| PRPS1 | ADSL | 0.734891 | 11 | 0 | 11 |
| PRPS1 | PET117 | 0.734628 | 3 | 0 | 3 |
| PRPS1 | TBC1D8B | 0.734245 | 3 | 0 | 3 |
| PRPS1 | ACD | 0.733851 | 11 | 0 | 10 |
| PRPS1 | SLC39A14 | 0.732536 | 12 | 0 | 11 |
| PRPS1 | NUDCD1 | 0.731216 | 6 | 0 | 6 |
| PRPS1 | ACBD6 | 0.730967 | 5 | 0 | 4 |
| PRPS1 | CKS1B | 0.730473 | 11 | 0 | 11 |
| PRPS1 | SNX10 | 0.729783 | 10 | 0 | 10 |
For details and further investigation, click here
