| Full name: dual specificity phosphatase 6 | Alias Symbol: MKP-3|PYST1 | ||
| Type: protein-coding gene | Cytoband: 12q21.33 | ||
| Entrez ID: 1848 | HGNC ID: HGNC:3072 | Ensembl Gene: ENSG00000139318 | OMIM ID: 602748 |
| Drug and gene relationship at DGIdb | |||
DUSP6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUSP6 | 1848 | 208892_s_at | 0.2706 | 0.7954 | |
| GSE20347 | DUSP6 | 1848 | 208891_at | 0.7047 | 0.0292 | |
| GSE23400 | DUSP6 | 1848 | 208891_at | 0.8585 | 0.0000 | |
| GSE26886 | DUSP6 | 1848 | 208891_at | 2.5553 | 0.0000 | |
| GSE29001 | DUSP6 | 1848 | 208891_at | 0.9174 | 0.0294 | |
| GSE38129 | DUSP6 | 1848 | 208891_at | 0.5449 | 0.0464 | |
| GSE45670 | DUSP6 | 1848 | 208892_s_at | -0.0414 | 0.9470 | |
| GSE53622 | DUSP6 | 1848 | 33323 | 0.6571 | 0.0000 | |
| GSE53624 | DUSP6 | 1848 | 33323 | 0.9368 | 0.0000 | |
| GSE63941 | DUSP6 | 1848 | 208891_at | -2.6557 | 0.0596 | |
| GSE77861 | DUSP6 | 1848 | 208891_at | 2.4064 | 0.0046 | |
| GSE97050 | DUSP6 | 1848 | A_23_P139704 | 0.6052 | 0.1956 | |
| SRP007169 | DUSP6 | 1848 | RNAseq | 1.8120 | 0.0000 | |
| SRP008496 | DUSP6 | 1848 | RNAseq | 2.1249 | 0.0000 | |
| SRP064894 | DUSP6 | 1848 | RNAseq | 0.9726 | 0.0000 | |
| SRP133303 | DUSP6 | 1848 | RNAseq | 0.9450 | 0.0068 | |
| SRP159526 | DUSP6 | 1848 | RNAseq | 1.0373 | 0.0311 | |
| SRP193095 | DUSP6 | 1848 | RNAseq | 1.5342 | 0.0000 | |
| SRP219564 | DUSP6 | 1848 | RNAseq | 0.8711 | 0.1389 | |
| TCGA | DUSP6 | 1848 | RNAseq | 0.1360 | 0.2013 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by DUSP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP6 | 1848 | 3 | 2 | 25 | |
| GSE20123 | DUSP6 | 1848 | 3 | 2 | 25 | |
| GSE43470 | DUSP6 | 1848 | 3 | 0 | 40 | |
| GSE46452 | DUSP6 | 1848 | 9 | 1 | 49 | |
| GSE47630 | DUSP6 | 1848 | 11 | 1 | 28 | |
| GSE54993 | DUSP6 | 1848 | 0 | 6 | 64 | |
| GSE54994 | DUSP6 | 1848 | 6 | 1 | 46 | |
| GSE60625 | DUSP6 | 1848 | 0 | 0 | 11 | |
| GSE74703 | DUSP6 | 1848 | 3 | 0 | 33 | |
| GSE74704 | DUSP6 | 1848 | 1 | 2 | 17 | |
| TCGA | DUSP6 | 1848 | 19 | 10 | 67 |
Total number of gains: 58; Total number of losses: 25; Total Number of normals: 405.
Somatic mutations of DUSP6:
Generating mutation plots.
Highly correlated genes for DUSP6:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP6 | PCDH18 | 0.761966 | 3 | 0 | 3 |
| DUSP6 | ALKBH6 | 0.749785 | 3 | 0 | 3 |
| DUSP6 | CPNE8 | 0.744887 | 3 | 0 | 3 |
| DUSP6 | PRTFDC1 | 0.720735 | 5 | 0 | 5 |
| DUSP6 | AFAP1L2 | 0.716129 | 4 | 0 | 4 |
| DUSP6 | STK32B | 0.714866 | 3 | 0 | 3 |
| DUSP6 | LRRC8C | 0.706782 | 3 | 0 | 3 |
| DUSP6 | FMNL2 | 0.706684 | 7 | 0 | 7 |
| DUSP6 | C11orf96 | 0.705952 | 4 | 0 | 3 |
| DUSP6 | TEX10 | 0.699423 | 3 | 0 | 3 |
| DUSP6 | IKBIP | 0.698765 | 7 | 0 | 7 |
| DUSP6 | RAB34 | 0.69764 | 3 | 0 | 3 |
| DUSP6 | RAD50 | 0.69453 | 3 | 0 | 3 |
| DUSP6 | FAM126A | 0.691799 | 4 | 0 | 3 |
| DUSP6 | USP40 | 0.690621 | 3 | 0 | 3 |
| DUSP6 | RILPL1 | 0.686164 | 4 | 0 | 4 |
| DUSP6 | IL4R | 0.684841 | 3 | 0 | 3 |
| DUSP6 | FBLIM1 | 0.684543 | 6 | 0 | 6 |
| DUSP6 | FADS1 | 0.684065 | 3 | 0 | 3 |
| DUSP6 | ITPA | 0.683371 | 3 | 0 | 3 |
For details and further investigation, click here
