| Full name: mannose receptor C type 2 | Alias Symbol: KIAA0709|ENDO180|CLEC13E|CD280 | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 9902 | HGNC ID: HGNC:16875 | Ensembl Gene: ENSG00000011028 | OMIM ID: 612264 |
| Drug and gene relationship at DGIdb | |||
MRC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05152 | Tuberculosis |
Expression of MRC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRC2 | 9902 | 37408_at | -0.0467 | 0.9074 | |
| GSE20347 | MRC2 | 9902 | 37408_at | -0.0909 | 0.6475 | |
| GSE23400 | MRC2 | 9902 | 37408_at | -0.0391 | 0.6322 | |
| GSE26886 | MRC2 | 9902 | 37408_at | 0.6287 | 0.1113 | |
| GSE29001 | MRC2 | 9902 | 37408_at | -0.2453 | 0.4445 | |
| GSE38129 | MRC2 | 9902 | 37408_at | -0.1685 | 0.3086 | |
| GSE45670 | MRC2 | 9902 | 37408_at | -0.6230 | 0.0045 | |
| GSE63941 | MRC2 | 9902 | 37408_at | -4.0363 | 0.0001 | |
| GSE77861 | MRC2 | 9902 | 37408_at | -0.1512 | 0.5704 | |
| GSE97050 | MRC2 | 9902 | A_33_P3364741 | 0.3380 | 0.4405 | |
| SRP007169 | MRC2 | 9902 | RNAseq | 0.4093 | 0.3072 | |
| SRP008496 | MRC2 | 9902 | RNAseq | 1.1437 | 0.0076 | |
| SRP064894 | MRC2 | 9902 | RNAseq | 0.9557 | 0.0001 | |
| SRP133303 | MRC2 | 9902 | RNAseq | 0.3204 | 0.3366 | |
| SRP159526 | MRC2 | 9902 | RNAseq | -0.3482 | 0.3293 | |
| SRP193095 | MRC2 | 9902 | RNAseq | 0.2513 | 0.3015 | |
| SRP219564 | MRC2 | 9902 | RNAseq | 0.6102 | 0.0636 | |
| TCGA | MRC2 | 9902 | RNAseq | 0.0285 | 0.7223 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by MRC2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MRC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRC2 | 9902 | 4 | 1 | 25 | |
| GSE20123 | MRC2 | 9902 | 4 | 1 | 25 | |
| GSE43470 | MRC2 | 9902 | 5 | 0 | 38 | |
| GSE46452 | MRC2 | 9902 | 31 | 0 | 28 | |
| GSE47630 | MRC2 | 9902 | 7 | 1 | 32 | |
| GSE54993 | MRC2 | 9902 | 2 | 5 | 63 | |
| GSE54994 | MRC2 | 9902 | 9 | 5 | 39 | |
| GSE60625 | MRC2 | 9902 | 4 | 0 | 7 | |
| GSE74703 | MRC2 | 9902 | 5 | 0 | 31 | |
| GSE74704 | MRC2 | 9902 | 3 | 1 | 16 | |
| TCGA | MRC2 | 9902 | 30 | 7 | 59 |
Total number of gains: 104; Total number of losses: 21; Total Number of normals: 363.
Somatic mutations of MRC2:
Generating mutation plots.
Highly correlated genes for MRC2:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRC2 | ST3GAL2 | 0.811998 | 3 | 0 | 3 |
| MRC2 | FIBIN | 0.774607 | 3 | 0 | 3 |
| MRC2 | ZDHHC14 | 0.772133 | 3 | 0 | 3 |
| MRC2 | ARHGAP31 | 0.771288 | 3 | 0 | 3 |
| MRC2 | TBC1D23 | 0.769276 | 3 | 0 | 3 |
| MRC2 | DPP4 | 0.765097 | 3 | 0 | 3 |
| MRC2 | PHRF1 | 0.752875 | 3 | 0 | 3 |
| MRC2 | PCDH18 | 0.749275 | 3 | 0 | 3 |
| MRC2 | PRRX2 | 0.74718 | 3 | 0 | 3 |
| MRC2 | USP4 | 0.746059 | 3 | 0 | 3 |
| MRC2 | TRIM23 | 0.741728 | 3 | 0 | 3 |
| MRC2 | GOLGA3 | 0.741712 | 3 | 0 | 3 |
| MRC2 | TSHZ3 | 0.738746 | 3 | 0 | 3 |
| MRC2 | ZNF469 | 0.73821 | 3 | 0 | 3 |
| MRC2 | C11orf24 | 0.733408 | 3 | 0 | 3 |
| MRC2 | CTF1 | 0.72116 | 3 | 0 | 3 |
| MRC2 | FAM160B1 | 0.715219 | 3 | 0 | 3 |
| MRC2 | CACNA2D4 | 0.713442 | 3 | 0 | 3 |
| MRC2 | AHRR | 0.713046 | 3 | 0 | 3 |
| MRC2 | ARSI | 0.707809 | 3 | 0 | 3 |
For details and further investigation, click here
