| Full name: piccolo presynaptic cytomatrix protein | Alias Symbol: KIAA0559|DKFZp779G1236|ACZ | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 27445 | HGNC ID: HGNC:13406 | Ensembl Gene: ENSG00000186472 | OMIM ID: 604918 |
| Drug and gene relationship at DGIdb | |||
PCLO involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion |
Expression of PCLO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCLO | 27445 | 213558_at | -0.1637 | 0.9107 | |
| GSE20347 | PCLO | 27445 | 213558_at | -0.2514 | 0.1285 | |
| GSE23400 | PCLO | 27445 | 213558_at | -0.0441 | 0.6612 | |
| GSE26886 | PCLO | 27445 | 213558_at | 1.1163 | 0.0237 | |
| GSE29001 | PCLO | 27445 | 213558_at | -0.1864 | 0.7934 | |
| GSE38129 | PCLO | 27445 | 213558_at | -0.1440 | 0.5875 | |
| GSE45670 | PCLO | 27445 | 213558_at | -0.1982 | 0.6890 | |
| GSE53622 | PCLO | 27445 | 68232 | -0.7710 | 0.0016 | |
| GSE53624 | PCLO | 27445 | 68232 | -0.9851 | 0.0000 | |
| GSE63941 | PCLO | 27445 | 213558_at | 1.4830 | 0.1301 | |
| GSE77861 | PCLO | 27445 | 213558_at | -0.0772 | 0.7783 | |
| SRP007169 | PCLO | 27445 | RNAseq | 1.1509 | 0.0681 | |
| SRP008496 | PCLO | 27445 | RNAseq | 1.6474 | 0.0007 | |
| SRP064894 | PCLO | 27445 | RNAseq | -0.5042 | 0.3113 | |
| SRP133303 | PCLO | 27445 | RNAseq | -0.6491 | 0.3287 | |
| SRP159526 | PCLO | 27445 | RNAseq | 0.3932 | 0.2983 | |
| SRP193095 | PCLO | 27445 | RNAseq | -0.1196 | 0.6534 | |
| SRP219564 | PCLO | 27445 | RNAseq | -0.8718 | 0.3112 | |
| TCGA | PCLO | 27445 | RNAseq | -0.0875 | 0.7258 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PCLO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCLO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCLO | 27445 | 12 | 1 | 17 | |
| GSE20123 | PCLO | 27445 | 11 | 1 | 18 | |
| GSE43470 | PCLO | 27445 | 4 | 1 | 38 | |
| GSE46452 | PCLO | 27445 | 11 | 0 | 48 | |
| GSE47630 | PCLO | 27445 | 7 | 3 | 30 | |
| GSE54993 | PCLO | 27445 | 1 | 7 | 62 | |
| GSE54994 | PCLO | 27445 | 16 | 3 | 34 | |
| GSE60625 | PCLO | 27445 | 0 | 0 | 11 | |
| GSE74703 | PCLO | 27445 | 3 | 1 | 32 | |
| GSE74704 | PCLO | 27445 | 7 | 1 | 12 | |
| TCGA | PCLO | 27445 | 46 | 8 | 42 |
Total number of gains: 118; Total number of losses: 26; Total Number of normals: 344.
Somatic mutations of PCLO:
Generating mutation plots.
Highly correlated genes for PCLO:
Showing all 18 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCLO | ATF7IP2 | 0.64437 | 3 | 0 | 3 |
| PCLO | OGT | 0.642051 | 3 | 0 | 3 |
| PCLO | GPR143 | 0.605165 | 4 | 0 | 3 |
| PCLO | ADPRM | 0.593436 | 3 | 0 | 3 |
| PCLO | OVOL2 | 0.58721 | 3 | 0 | 3 |
| PCLO | GPATCH1 | 0.574362 | 5 | 0 | 4 |
| PCLO | RPS6KA5 | 0.57073 | 4 | 0 | 3 |
| PCLO | HOOK1 | 0.561412 | 3 | 0 | 3 |
| PCLO | FANCF | 0.558597 | 6 | 0 | 4 |
| PCLO | N4BP2L2 | 0.552427 | 3 | 0 | 3 |
| PCLO | UGGT2 | 0.548536 | 3 | 0 | 3 |
| PCLO | CSAD | 0.54043 | 3 | 0 | 3 |
| PCLO | NCOR1 | 0.528748 | 5 | 0 | 3 |
| PCLO | ZNF33B | 0.527709 | 5 | 0 | 3 |
| PCLO | C11orf49 | 0.51757 | 6 | 0 | 3 |
| PCLO | MRPS31 | 0.515021 | 4 | 0 | 3 |
| PCLO | CASP8 | 0.513445 | 4 | 0 | 3 |
| PCLO | TFB1M | 0.508475 | 4 | 0 | 3 |
For details and further investigation, click here
