CASP8

 

Full name: caspase 8 Alias Symbol: MCH5|MACH|FLICE|Casp-8
Type: protein-coding gene Cytoband: 2q33.1
Entrez ID: 841 HGNC ID: HGNC:1509 Ensembl Gene: ENSG00000064012 OMIM ID: 601763
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CASP8 involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04668TNF signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05168Herpes simplex infection
hsa05200Pathways in cancer

 

Expression of CASP8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CASP8 841 213373_s_at -0.0102 0.9928
GSE20347 CASP8 841 213373_s_at -0.3485 0.1271
GSE23400 CASP8 841 213373_s_at 0.2319 0.0122
GSE26886 CASP8 841 213373_s_at -0.0261 0.9377
GSE29001 CASP8 841 213373_s_at -0.1465 0.5074
GSE38129 CASP8 841 213373_s_at 0.0063 0.9816
GSE45670 CASP8 841 213373_s_at 0.1889 0.2204
GSE53622 CASP8 841 97695 -0.0245 0.7744
GSE53624 CASP8 841 97695 -0.2293 0.0003
GSE63941 CASP8 841 213373_s_at 0.6518 0.1768
GSE77861 CASP8 841 213373_s_at -0.4349 0.4369
GSE97050 CASP8 841 A_24_P148499 0.4483 0.2850
SRP007169 CASP8 841 RNAseq -0.3123 0.5559
SRP008496 CASP8 841 RNAseq 0.1081 0.8073
SRP064894 CASP8 841 RNAseq -0.2549 0.3275
SRP133303 CASP8 841 RNAseq -0.0024 0.9900
SRP159526 CASP8 841 RNAseq -0.4672 0.1255
SRP193095 CASP8 841 RNAseq -0.0368 0.7958
SRP219564 CASP8 841 RNAseq -0.1149 0.8094
TCGA CASP8 841 RNAseq 0.2020 0.0025

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CASP8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CASP8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CASP8 841 6 4 20
GSE20123 CASP8 841 6 4 20
GSE43470 CASP8 841 1 1 41
GSE46452 CASP8 841 1 4 54
GSE47630 CASP8 841 4 5 31
GSE54993 CASP8 841 0 3 67
GSE54994 CASP8 841 10 8 35
GSE60625 CASP8 841 0 3 8
GSE74703 CASP8 841 1 1 34
GSE74704 CASP8 841 3 2 15
TCGA CASP8 841 21 12 63

Total number of gains: 53; Total number of losses: 47; Total Number of normals: 388.  

 

Somatic mutations of CASP8:

 

Generating mutation plots.

 

Highly correlated genes for CASP8:

 

Showing top 20/78 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CASP8SMC50.76717303
CASP8ZAP700.735284303
CASP8FOPNL0.713476303
CASP8RBL10.703043303
CASP8OXNAD10.692702303
CASP8TDRD50.683889303
CASP8MXD30.680326303
CASP8TAP20.671871403
CASP8DEAF10.665962303
CASP8ZNF5710.649706303
CASP8PTPN70.649126403
CASP8MSH30.646305303
CASP8BTLA0.645262403
CASP8METTL90.639578403
CASP8MYCBP20.629324504
CASP8TFAP2A0.627189503
CASP8UNC5CL0.624796403
CASP8COBLL10.619525303
CASP8ELL30.619028403
CASP8CYP4X10.616811303

For details and further investigation, click here