| Full name: ribosomal protein S6 kinase A5 | Alias Symbol: MSK1|RLPK | ||
| Type: protein-coding gene | Cytoband: 14q32.11 | ||
| Entrez ID: 9252 | HGNC ID: HGNC:10434 | Ensembl Gene: ENSG00000100784 | OMIM ID: 603607 |
| Drug and gene relationship at DGIdb | |||
RPS6KA5 involved pathways:
Expression of RPS6KA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KA5 | 9252 | 204633_s_at | -0.0281 | 0.9801 | |
| GSE20347 | RPS6KA5 | 9252 | 204633_s_at | 0.0520 | 0.8676 | |
| GSE23400 | RPS6KA5 | 9252 | 204633_s_at | -0.0229 | 0.8442 | |
| GSE26886 | RPS6KA5 | 9252 | 204633_s_at | 0.6055 | 0.0688 | |
| GSE29001 | RPS6KA5 | 9252 | 204633_s_at | -0.0184 | 0.9545 | |
| GSE38129 | RPS6KA5 | 9252 | 204633_s_at | -0.3345 | 0.1189 | |
| GSE45670 | RPS6KA5 | 9252 | 204633_s_at | -0.5146 | 0.0396 | |
| GSE53622 | RPS6KA5 | 9252 | 28655 | -0.4410 | 0.0000 | |
| GSE53624 | RPS6KA5 | 9252 | 28655 | -0.2484 | 0.0008 | |
| GSE63941 | RPS6KA5 | 9252 | 204633_s_at | 2.0540 | 0.0131 | |
| GSE77861 | RPS6KA5 | 9252 | 204633_s_at | 0.4797 | 0.1882 | |
| GSE97050 | RPS6KA5 | 9252 | A_23_P37375 | -0.5125 | 0.3784 | |
| SRP007169 | RPS6KA5 | 9252 | RNAseq | 1.1832 | 0.0163 | |
| SRP008496 | RPS6KA5 | 9252 | RNAseq | 0.8420 | 0.0308 | |
| SRP064894 | RPS6KA5 | 9252 | RNAseq | -0.2613 | 0.4441 | |
| SRP133303 | RPS6KA5 | 9252 | RNAseq | -0.1857 | 0.3903 | |
| SRP159526 | RPS6KA5 | 9252 | RNAseq | 0.0803 | 0.8488 | |
| SRP193095 | RPS6KA5 | 9252 | RNAseq | 0.2127 | 0.2373 | |
| SRP219564 | RPS6KA5 | 9252 | RNAseq | -0.1172 | 0.8333 | |
| TCGA | RPS6KA5 | 9252 | RNAseq | -0.3361 | 0.0004 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RPS6KA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KA5 | 9252 | 9 | 5 | 16 | |
| GSE20123 | RPS6KA5 | 9252 | 9 | 5 | 16 | |
| GSE43470 | RPS6KA5 | 9252 | 7 | 3 | 33 | |
| GSE46452 | RPS6KA5 | 9252 | 16 | 3 | 40 | |
| GSE47630 | RPS6KA5 | 9252 | 11 | 8 | 21 | |
| GSE54993 | RPS6KA5 | 9252 | 3 | 8 | 59 | |
| GSE54994 | RPS6KA5 | 9252 | 19 | 4 | 30 | |
| GSE60625 | RPS6KA5 | 9252 | 0 | 2 | 9 | |
| GSE74703 | RPS6KA5 | 9252 | 6 | 3 | 27 | |
| GSE74704 | RPS6KA5 | 9252 | 4 | 4 | 12 | |
| TCGA | RPS6KA5 | 9252 | 30 | 22 | 44 |
Total number of gains: 114; Total number of losses: 67; Total Number of normals: 307.
Somatic mutations of RPS6KA5:
Generating mutation plots.
Highly correlated genes for RPS6KA5:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KA5 | NAP1L1 | 0.66559 | 3 | 0 | 3 |
| RPS6KA5 | PAIP1 | 0.660306 | 3 | 0 | 3 |
| RPS6KA5 | PRKAB2 | 0.652952 | 4 | 0 | 4 |
| RPS6KA5 | KLHL23 | 0.643612 | 4 | 0 | 4 |
| RPS6KA5 | CADM2 | 0.643237 | 3 | 0 | 3 |
| RPS6KA5 | ZKSCAN8 | 0.642312 | 3 | 0 | 3 |
| RPS6KA5 | CREB3L4 | 0.629881 | 3 | 0 | 3 |
| RPS6KA5 | GLP2R | 0.628866 | 3 | 0 | 3 |
| RPS6KA5 | OSGIN2 | 0.624354 | 4 | 0 | 4 |
| RPS6KA5 | BRD3 | 0.621944 | 4 | 0 | 3 |
| RPS6KA5 | ZNF232 | 0.617714 | 4 | 0 | 3 |
| RPS6KA5 | FGF13 | 0.604563 | 5 | 0 | 4 |
| RPS6KA5 | FZD3 | 0.60438 | 4 | 0 | 3 |
| RPS6KA5 | COL4A6 | 0.601186 | 6 | 0 | 4 |
| RPS6KA5 | PNMA1 | 0.60061 | 4 | 0 | 3 |
| RPS6KA5 | RNF139 | 0.599702 | 3 | 0 | 3 |
| RPS6KA5 | ASB2 | 0.59967 | 6 | 0 | 4 |
| RPS6KA5 | SNX27 | 0.596936 | 4 | 0 | 3 |
| RPS6KA5 | SERGEF | 0.594799 | 5 | 0 | 4 |
| RPS6KA5 | ZBTB8A | 0.594005 | 4 | 0 | 3 |
For details and further investigation, click here
