| Full name: nuclear receptor corepressor 1 | Alias Symbol: N-CoR|hCIT529I10|TRAC1|hN-CoR|KIAA1047|MGC104216|PPP1R109 | ||
| Type: protein-coding gene | Cytoband: 17p12-p11.2 | ||
| Entrez ID: 9611 | HGNC ID: HGNC:7672 | Ensembl Gene: ENSG00000141027 | OMIM ID: 600849 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NCOR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCOR1 | 9611 | 200854_at | -0.2006 | 0.4253 | |
| GSE20347 | NCOR1 | 9611 | 200854_at | -0.2935 | 0.0691 | |
| GSE23400 | NCOR1 | 9611 | 200857_s_at | -0.2083 | 0.0000 | |
| GSE26886 | NCOR1 | 9611 | 200854_at | 0.1938 | 0.2933 | |
| GSE29001 | NCOR1 | 9611 | 200854_at | -0.1430 | 0.4771 | |
| GSE38129 | NCOR1 | 9611 | 200854_at | -0.2877 | 0.0086 | |
| GSE45670 | NCOR1 | 9611 | 200854_at | -0.0679 | 0.6636 | |
| GSE53622 | NCOR1 | 9611 | 59789 | -0.0060 | 0.9180 | |
| GSE53624 | NCOR1 | 9611 | 59789 | -0.1581 | 0.0026 | |
| GSE63941 | NCOR1 | 9611 | 200854_at | -0.0392 | 0.9506 | |
| GSE77861 | NCOR1 | 9611 | 200854_at | -0.0738 | 0.8189 | |
| GSE97050 | NCOR1 | 9611 | A_24_P204214 | 0.1154 | 0.5193 | |
| SRP007169 | NCOR1 | 9611 | RNAseq | 0.9334 | 0.0372 | |
| SRP008496 | NCOR1 | 9611 | RNAseq | 0.9233 | 0.0001 | |
| SRP064894 | NCOR1 | 9611 | RNAseq | 0.5106 | 0.0692 | |
| SRP133303 | NCOR1 | 9611 | RNAseq | -0.0706 | 0.4292 | |
| SRP159526 | NCOR1 | 9611 | RNAseq | -0.2220 | 0.0983 | |
| SRP193095 | NCOR1 | 9611 | RNAseq | -0.1668 | 0.2072 | |
| SRP219564 | NCOR1 | 9611 | RNAseq | -0.0410 | 0.8517 | |
| TCGA | NCOR1 | 9611 | RNAseq | -0.1570 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NCOR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NCOR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCOR1 | 9611 | 3 | 3 | 24 | |
| GSE20123 | NCOR1 | 9611 | 3 | 4 | 23 | |
| GSE43470 | NCOR1 | 9611 | 2 | 5 | 36 | |
| GSE46452 | NCOR1 | 9611 | 34 | 1 | 24 | |
| GSE47630 | NCOR1 | 9611 | 7 | 1 | 32 | |
| GSE54993 | NCOR1 | 9611 | 3 | 3 | 64 | |
| GSE54994 | NCOR1 | 9611 | 6 | 5 | 42 | |
| GSE60625 | NCOR1 | 9611 | 4 | 0 | 7 | |
| GSE74703 | NCOR1 | 9611 | 2 | 2 | 32 | |
| GSE74704 | NCOR1 | 9611 | 2 | 1 | 17 | |
| TCGA | NCOR1 | 9611 | 17 | 26 | 53 |
Total number of gains: 83; Total number of losses: 51; Total Number of normals: 354.
Somatic mutations of NCOR1:
Generating mutation plots.
Highly correlated genes for NCOR1:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCOR1 | FRAS1 | 0.795498 | 3 | 0 | 3 |
| NCOR1 | MTMR12 | 0.783447 | 3 | 0 | 3 |
| NCOR1 | TMEM218 | 0.771894 | 4 | 0 | 4 |
| NCOR1 | C15orf41 | 0.758333 | 3 | 0 | 3 |
| NCOR1 | AGBL5 | 0.754191 | 3 | 0 | 3 |
| NCOR1 | KLHDC2 | 0.749532 | 3 | 0 | 3 |
| NCOR1 | ECD | 0.7427 | 3 | 0 | 3 |
| NCOR1 | IFT46 | 0.741427 | 4 | 0 | 3 |
| NCOR1 | BBS1 | 0.737814 | 3 | 0 | 3 |
| NCOR1 | IFNAR1 | 0.734178 | 3 | 0 | 3 |
| NCOR1 | TRERF1 | 0.731809 | 3 | 0 | 3 |
| NCOR1 | MCCC1 | 0.73144 | 3 | 0 | 3 |
| NCOR1 | FGFR2 | 0.730145 | 3 | 0 | 3 |
| NCOR1 | PGAP2 | 0.727557 | 3 | 0 | 3 |
| NCOR1 | CTPS2 | 0.724349 | 4 | 0 | 4 |
| NCOR1 | GPR19 | 0.722405 | 3 | 0 | 3 |
| NCOR1 | TMEM109 | 0.715843 | 3 | 0 | 3 |
| NCOR1 | ANAPC16 | 0.713448 | 3 | 0 | 3 |
| NCOR1 | TUBGCP4 | 0.71255 | 3 | 0 | 3 |
| NCOR1 | ELL3 | 0.7103 | 3 | 0 | 3 |
For details and further investigation, click here
