| Full name: ubiquitin specific peptidase 49 | Alias Symbol: MGC20741 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 25862 | HGNC ID: HGNC:20078 | Ensembl Gene: ENSG00000164663 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of USP49:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP49 | 25862 | 229351_at | 0.6040 | 0.3087 | |
| GSE20347 | USP49 | 25862 | 220667_at | 0.0344 | 0.5614 | |
| GSE23400 | USP49 | 25862 | 220667_at | 0.0445 | 0.1837 | |
| GSE26886 | USP49 | 25862 | 229351_at | -0.2505 | 0.2320 | |
| GSE29001 | USP49 | 25862 | 220667_at | 0.0262 | 0.9033 | |
| GSE38129 | USP49 | 25862 | 220667_at | 0.0335 | 0.6228 | |
| GSE45670 | USP49 | 25862 | 229351_at | -0.0650 | 0.6874 | |
| GSE53622 | USP49 | 25862 | 75483 | 0.2878 | 0.0000 | |
| GSE53624 | USP49 | 25862 | 75483 | 0.3611 | 0.0000 | |
| GSE63941 | USP49 | 25862 | 229351_at | 0.0634 | 0.8844 | |
| GSE77861 | USP49 | 25862 | 229351_at | 0.0953 | 0.5260 | |
| GSE97050 | USP49 | 25862 | A_33_P3389973 | 0.2792 | 0.2689 | |
| SRP007169 | USP49 | 25862 | RNAseq | 1.0375 | 0.0471 | |
| SRP008496 | USP49 | 25862 | RNAseq | 0.7375 | 0.1013 | |
| SRP064894 | USP49 | 25862 | RNAseq | 0.2136 | 0.3307 | |
| SRP133303 | USP49 | 25862 | RNAseq | 0.1758 | 0.1982 | |
| SRP159526 | USP49 | 25862 | RNAseq | 0.1211 | 0.5913 | |
| SRP193095 | USP49 | 25862 | RNAseq | 0.2565 | 0.0486 | |
| SRP219564 | USP49 | 25862 | RNAseq | 0.1661 | 0.5988 | |
| TCGA | USP49 | 25862 | RNAseq | 0.1814 | 0.1811 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by USP49 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP49:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP49 | 25862 | 6 | 1 | 23 | |
| GSE20123 | USP49 | 25862 | 6 | 1 | 23 | |
| GSE43470 | USP49 | 25862 | 6 | 0 | 37 | |
| GSE46452 | USP49 | 25862 | 2 | 9 | 48 | |
| GSE47630 | USP49 | 25862 | 8 | 4 | 28 | |
| GSE54993 | USP49 | 25862 | 3 | 2 | 65 | |
| GSE54994 | USP49 | 25862 | 11 | 4 | 38 | |
| GSE60625 | USP49 | 25862 | 0 | 1 | 10 | |
| GSE74703 | USP49 | 25862 | 6 | 0 | 30 | |
| GSE74704 | USP49 | 25862 | 3 | 1 | 16 | |
| TCGA | USP49 | 25862 | 21 | 13 | 62 |
Total number of gains: 72; Total number of losses: 36; Total Number of normals: 380.
Somatic mutations of USP49:
Generating mutation plots.
Highly correlated genes for USP49:
Showing top 20/217 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP49 | ZDHHC23 | 0.779904 | 3 | 0 | 3 |
| USP49 | APTX | 0.768711 | 3 | 0 | 3 |
| USP49 | DMC1 | 0.763785 | 4 | 0 | 3 |
| USP49 | ZNF341 | 0.761602 | 3 | 0 | 3 |
| USP49 | POLD1 | 0.754606 | 3 | 0 | 3 |
| USP49 | VAV2 | 0.747149 | 3 | 0 | 3 |
| USP49 | PDE6C | 0.74621 | 3 | 0 | 3 |
| USP49 | MFSD11 | 0.741687 | 5 | 0 | 5 |
| USP49 | DAB1 | 0.730109 | 5 | 0 | 5 |
| USP49 | SCGN | 0.729589 | 4 | 0 | 4 |
| USP49 | MYBPH | 0.729273 | 3 | 0 | 3 |
| USP49 | BRS3 | 0.721826 | 3 | 0 | 3 |
| USP49 | PRR15 | 0.713924 | 3 | 0 | 3 |
| USP49 | BTNL2 | 0.711316 | 4 | 0 | 4 |
| USP49 | PDCD11 | 0.708543 | 3 | 0 | 3 |
| USP49 | PRDM13 | 0.707989 | 4 | 0 | 3 |
| USP49 | POU1F1 | 0.704094 | 3 | 0 | 3 |
| USP49 | FRMPD4 | 0.702318 | 3 | 0 | 3 |
| USP49 | CHRNA5 | 0.699345 | 3 | 0 | 3 |
| USP49 | CD8B | 0.697854 | 3 | 0 | 3 |
For details and further investigation, click here
