| Full name: dopa decarboxylase | Alias Symbol: AADC | ||
| Type: protein-coding gene | Cytoband: 7p12.2-p12.1 | ||
| Entrez ID: 1644 | HGNC ID: HGNC:2719 | Ensembl Gene: ENSG00000132437 | OMIM ID: 107930 |
| Drug and gene relationship at DGIdb | |||
Expression of DDC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDC | 1644 | 205311_at | 0.1820 | 0.6999 | |
| GSE20347 | DDC | 1644 | 205311_at | 0.6764 | 0.0434 | |
| GSE23400 | DDC | 1644 | 205311_at | 0.3744 | 0.0105 | |
| GSE26886 | DDC | 1644 | 214347_s_at | -0.0527 | 0.7596 | |
| GSE29001 | DDC | 1644 | 205311_at | 0.0184 | 0.9165 | |
| GSE38129 | DDC | 1644 | 205311_at | 0.9169 | 0.0181 | |
| GSE45670 | DDC | 1644 | 214347_s_at | -0.0779 | 0.3539 | |
| GSE53622 | DDC | 1644 | 36052 | 0.1934 | 0.0008 | |
| GSE53624 | DDC | 1644 | 36052 | 0.0563 | 0.5690 | |
| GSE63941 | DDC | 1644 | 205311_at | 0.3401 | 0.6825 | |
| GSE77861 | DDC | 1644 | 214347_s_at | -0.1355 | 0.1522 | |
| GSE97050 | DDC | 1644 | A_33_P3355004 | -0.0805 | 0.7707 | |
| TCGA | DDC | 1644 | RNAseq | -0.8095 | 0.2953 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDC | 1644 | 12 | 0 | 18 | |
| GSE20123 | DDC | 1644 | 11 | 0 | 19 | |
| GSE43470 | DDC | 1644 | 4 | 1 | 38 | |
| GSE46452 | DDC | 1644 | 11 | 1 | 47 | |
| GSE47630 | DDC | 1644 | 8 | 1 | 31 | |
| GSE54993 | DDC | 1644 | 0 | 8 | 62 | |
| GSE54994 | DDC | 1644 | 18 | 2 | 33 | |
| GSE60625 | DDC | 1644 | 0 | 0 | 11 | |
| GSE74703 | DDC | 1644 | 4 | 1 | 31 | |
| GSE74704 | DDC | 1644 | 5 | 0 | 15 | |
| TCGA | DDC | 1644 | 48 | 10 | 38 |
Total number of gains: 121; Total number of losses: 24; Total Number of normals: 343.
Somatic mutations of DDC:
Generating mutation plots.
Highly correlated genes for DDC:
Showing top 20/396 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDC | NLRP6 | 0.787978 | 3 | 0 | 3 |
| DDC | YY2 | 0.785958 | 3 | 0 | 3 |
| DDC | OR2T1 | 0.782787 | 3 | 0 | 3 |
| DDC | CABP1 | 0.778352 | 4 | 0 | 4 |
| DDC | OTOG | 0.777218 | 3 | 0 | 3 |
| DDC | PDE6C | 0.775586 | 3 | 0 | 3 |
| DDC | OR2A5 | 0.775372 | 3 | 0 | 3 |
| DDC | RBM43 | 0.769782 | 3 | 0 | 3 |
| DDC | OR2B11 | 0.769362 | 3 | 0 | 3 |
| DDC | DNAH6 | 0.765209 | 3 | 0 | 3 |
| DDC | TTLL3 | 0.761842 | 3 | 0 | 3 |
| DDC | PRSS38 | 0.759361 | 3 | 0 | 3 |
| DDC | CPLX2 | 0.75586 | 3 | 0 | 3 |
| DDC | MYO1A | 0.752332 | 3 | 0 | 3 |
| DDC | TTC21A | 0.751359 | 3 | 0 | 3 |
| DDC | TEX13B | 0.746135 | 3 | 0 | 3 |
| DDC | SIM1 | 0.745997 | 4 | 0 | 4 |
| DDC | OR10AD1 | 0.742868 | 3 | 0 | 3 |
| DDC | USP51 | 0.741193 | 3 | 0 | 3 |
| DDC | GPHA2 | 0.740683 | 4 | 0 | 3 |
For details and further investigation, click here
