| Full name: phosphodiesterase 6D | Alias Symbol: JBTS22 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 5147 | HGNC ID: HGNC:8788 | Ensembl Gene: ENSG00000156973 | OMIM ID: 602676 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE6D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE6D | 5147 | 204091_at | -0.0901 | 0.8690 | |
| GSE20347 | PDE6D | 5147 | 204091_at | 0.0233 | 0.8846 | |
| GSE23400 | PDE6D | 5147 | 216883_x_at | -0.0311 | 0.4277 | |
| GSE26886 | PDE6D | 5147 | 204091_at | 0.8593 | 0.0003 | |
| GSE29001 | PDE6D | 5147 | 204091_at | 0.1092 | 0.7738 | |
| GSE38129 | PDE6D | 5147 | 204091_at | 0.0506 | 0.7154 | |
| GSE45670 | PDE6D | 5147 | 204091_at | 0.1797 | 0.2352 | |
| GSE53622 | PDE6D | 5147 | 49033 | 0.3884 | 0.0000 | |
| GSE53624 | PDE6D | 5147 | 49033 | 0.2917 | 0.0001 | |
| GSE63941 | PDE6D | 5147 | 204091_at | 0.4003 | 0.1864 | |
| GSE77861 | PDE6D | 5147 | 204091_at | 0.2794 | 0.1379 | |
| GSE97050 | PDE6D | 5147 | A_23_P102517 | 0.2243 | 0.4951 | |
| SRP007169 | PDE6D | 5147 | RNAseq | -0.3674 | 0.3746 | |
| SRP008496 | PDE6D | 5147 | RNAseq | 0.0548 | 0.8609 | |
| SRP064894 | PDE6D | 5147 | RNAseq | 0.3108 | 0.0605 | |
| SRP133303 | PDE6D | 5147 | RNAseq | 0.4811 | 0.0006 | |
| SRP159526 | PDE6D | 5147 | RNAseq | 0.0187 | 0.9372 | |
| SRP193095 | PDE6D | 5147 | RNAseq | 0.0638 | 0.4648 | |
| SRP219564 | PDE6D | 5147 | RNAseq | 0.0753 | 0.8481 | |
| TCGA | PDE6D | 5147 | RNAseq | 0.1763 | 0.0043 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDE6D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE6D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE6D | 5147 | 1 | 12 | 17 | |
| GSE20123 | PDE6D | 5147 | 1 | 12 | 17 | |
| GSE43470 | PDE6D | 5147 | 1 | 8 | 34 | |
| GSE46452 | PDE6D | 5147 | 0 | 5 | 54 | |
| GSE47630 | PDE6D | 5147 | 4 | 5 | 31 | |
| GSE54993 | PDE6D | 5147 | 2 | 2 | 66 | |
| GSE54994 | PDE6D | 5147 | 6 | 10 | 37 | |
| GSE60625 | PDE6D | 5147 | 0 | 3 | 8 | |
| GSE74703 | PDE6D | 5147 | 1 | 6 | 29 | |
| GSE74704 | PDE6D | 5147 | 1 | 5 | 14 | |
| TCGA | PDE6D | 5147 | 12 | 27 | 57 |
Total number of gains: 29; Total number of losses: 95; Total Number of normals: 364.
Somatic mutations of PDE6D:
Generating mutation plots.
Highly correlated genes for PDE6D:
Showing top 20/789 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE6D | FAM199X | 0.822317 | 3 | 0 | 3 |
| PDE6D | LMBR1 | 0.778328 | 3 | 0 | 3 |
| PDE6D | CDC42EP3 | 0.775598 | 3 | 0 | 3 |
| PDE6D | U2SURP | 0.775075 | 3 | 0 | 3 |
| PDE6D | TTI2 | 0.75567 | 3 | 0 | 3 |
| PDE6D | STK17A | 0.755339 | 3 | 0 | 3 |
| PDE6D | NHLRC2 | 0.753738 | 3 | 0 | 3 |
| PDE6D | TXNDC16 | 0.752904 | 3 | 0 | 3 |
| PDE6D | PET117 | 0.752891 | 3 | 0 | 3 |
| PDE6D | ZFP37 | 0.752795 | 3 | 0 | 3 |
| PDE6D | RRNAD1 | 0.750911 | 3 | 0 | 3 |
| PDE6D | CCDC14 | 0.745546 | 3 | 0 | 3 |
| PDE6D | COLEC11 | 0.745326 | 3 | 0 | 3 |
| PDE6D | KLF10 | 0.741276 | 3 | 0 | 3 |
| PDE6D | AGGF1 | 0.737551 | 3 | 0 | 3 |
| PDE6D | GNB5 | 0.734246 | 4 | 0 | 3 |
| PDE6D | ZCCHC8 | 0.731592 | 3 | 0 | 3 |
| PDE6D | GOLIM4 | 0.729782 | 3 | 0 | 3 |
| PDE6D | SARNP | 0.725824 | 3 | 0 | 3 |
| PDE6D | COX10 | 0.719725 | 3 | 0 | 3 |
For details and further investigation, click here
