| Full name: NHL repeat containing 2 | Alias Symbol: FLJ25621|FLJ20147|FLJ33312|MGC45492|DKFZp779F115 | ||
| Type: protein-coding gene | Cytoband: 10q25.3 | ||
| Entrez ID: 374354 | HGNC ID: HGNC:24731 | Ensembl Gene: ENSG00000196865 | OMIM ID: 618277 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NHLRC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NHLRC2 | 374354 | 219353_at | 0.0907 | 0.8724 | |
| GSE20347 | NHLRC2 | 374354 | 219353_at | -0.0277 | 0.8997 | |
| GSE23400 | NHLRC2 | 374354 | 219353_at | -0.0099 | 0.9031 | |
| GSE26886 | NHLRC2 | 374354 | 219353_at | 0.2456 | 0.4628 | |
| GSE29001 | NHLRC2 | 374354 | 219353_at | 0.3181 | 0.1993 | |
| GSE38129 | NHLRC2 | 374354 | 219353_at | -0.2525 | 0.2078 | |
| GSE45670 | NHLRC2 | 374354 | 219353_at | -0.2390 | 0.1424 | |
| GSE53622 | NHLRC2 | 374354 | 52714 | -0.1751 | 0.0268 | |
| GSE53624 | NHLRC2 | 374354 | 52714 | 0.0084 | 0.8764 | |
| GSE63941 | NHLRC2 | 374354 | 219353_at | -0.4963 | 0.2585 | |
| GSE77861 | NHLRC2 | 374354 | 219353_at | 0.2086 | 0.3748 | |
| GSE97050 | NHLRC2 | 374354 | A_24_P252780 | -0.3815 | 0.3270 | |
| SRP007169 | NHLRC2 | 374354 | RNAseq | 0.2100 | 0.6125 | |
| SRP008496 | NHLRC2 | 374354 | RNAseq | 0.5881 | 0.0247 | |
| SRP064894 | NHLRC2 | 374354 | RNAseq | -0.3011 | 0.1634 | |
| SRP133303 | NHLRC2 | 374354 | RNAseq | 0.1058 | 0.4199 | |
| SRP159526 | NHLRC2 | 374354 | RNAseq | -0.1345 | 0.6413 | |
| SRP193095 | NHLRC2 | 374354 | RNAseq | 0.0519 | 0.4749 | |
| SRP219564 | NHLRC2 | 374354 | RNAseq | -0.0973 | 0.7044 | |
| TCGA | NHLRC2 | 374354 | RNAseq | -0.2043 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NHLRC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NHLRC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NHLRC2 | 374354 | 1 | 8 | 21 | |
| GSE20123 | NHLRC2 | 374354 | 1 | 7 | 22 | |
| GSE43470 | NHLRC2 | 374354 | 0 | 9 | 34 | |
| GSE46452 | NHLRC2 | 374354 | 0 | 11 | 48 | |
| GSE47630 | NHLRC2 | 374354 | 2 | 14 | 24 | |
| GSE54993 | NHLRC2 | 374354 | 8 | 0 | 62 | |
| GSE54994 | NHLRC2 | 374354 | 1 | 10 | 42 | |
| GSE60625 | NHLRC2 | 374354 | 0 | 0 | 11 | |
| GSE74703 | NHLRC2 | 374354 | 0 | 6 | 30 | |
| GSE74704 | NHLRC2 | 374354 | 1 | 3 | 16 | |
| TCGA | NHLRC2 | 374354 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of NHLRC2:
Generating mutation plots.
Highly correlated genes for NHLRC2:
Showing top 20/757 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NHLRC2 | NDUFA12 | 0.755658 | 3 | 0 | 3 |
| NHLRC2 | PDE6D | 0.753738 | 3 | 0 | 3 |
| NHLRC2 | WDR35 | 0.753495 | 5 | 0 | 5 |
| NHLRC2 | RRM2B | 0.749202 | 3 | 0 | 3 |
| NHLRC2 | TMEM25 | 0.749021 | 3 | 0 | 3 |
| NHLRC2 | ZNF322 | 0.733904 | 3 | 0 | 3 |
| NHLRC2 | ANKIB1 | 0.727543 | 3 | 0 | 3 |
| NHLRC2 | ZNF518B | 0.715552 | 3 | 0 | 3 |
| NHLRC2 | CFL2 | 0.710032 | 3 | 0 | 3 |
| NHLRC2 | SOS1 | 0.699102 | 4 | 0 | 3 |
| NHLRC2 | FAM160B1 | 0.696689 | 7 | 0 | 7 |
| NHLRC2 | MEPCE | 0.694796 | 3 | 0 | 3 |
| NHLRC2 | ZNF317 | 0.692025 | 3 | 0 | 3 |
| NHLRC2 | CCNT1 | 0.69013 | 4 | 0 | 4 |
| NHLRC2 | DDX5 | 0.688864 | 5 | 0 | 4 |
| NHLRC2 | TMED8 | 0.688052 | 3 | 0 | 3 |
| NHLRC2 | PDK2 | 0.686151 | 3 | 0 | 3 |
| NHLRC2 | GTF3C4 | 0.685316 | 3 | 0 | 3 |
| NHLRC2 | C17orf80 | 0.683722 | 4 | 0 | 3 |
| NHLRC2 | BUD31 | 0.682198 | 3 | 0 | 3 |
For details and further investigation, click here
