| Full name: peroxisomal biogenesis factor 6 | Alias Symbol: PXAAA1|PAF-2 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 5190 | HGNC ID: HGNC:8859 | Ensembl Gene: ENSG00000124587 | OMIM ID: 601498 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PEX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PEX6 | 5190 | 204545_at | -0.2288 | 0.7293 | |
| GSE20347 | PEX6 | 5190 | 204545_at | -0.1739 | 0.4449 | |
| GSE23400 | PEX6 | 5190 | 204545_at | -0.0670 | 0.4572 | |
| GSE26886 | PEX6 | 5190 | 204545_at | -0.6518 | 0.1857 | |
| GSE29001 | PEX6 | 5190 | 204545_at | -0.0708 | 0.8126 | |
| GSE38129 | PEX6 | 5190 | 204545_at | -0.0152 | 0.9560 | |
| GSE45670 | PEX6 | 5190 | 320_at | 0.0935 | 0.5117 | |
| GSE53622 | PEX6 | 5190 | 66329 | -0.0730 | 0.2817 | |
| GSE53624 | PEX6 | 5190 | 66329 | -0.0441 | 0.5515 | |
| GSE63941 | PEX6 | 5190 | 204545_at | 0.4293 | 0.6202 | |
| GSE77861 | PEX6 | 5190 | 320_at | -0.1636 | 0.2869 | |
| GSE97050 | PEX6 | 5190 | A_23_P42144 | 0.0064 | 0.9808 | |
| SRP007169 | PEX6 | 5190 | RNAseq | -1.0126 | 0.0612 | |
| SRP008496 | PEX6 | 5190 | RNAseq | -1.0079 | 0.0158 | |
| SRP064894 | PEX6 | 5190 | RNAseq | 0.4877 | 0.1095 | |
| SRP133303 | PEX6 | 5190 | RNAseq | -0.1094 | 0.7249 | |
| SRP159526 | PEX6 | 5190 | RNAseq | -0.0453 | 0.8645 | |
| SRP193095 | PEX6 | 5190 | RNAseq | -0.1843 | 0.3060 | |
| SRP219564 | PEX6 | 5190 | RNAseq | 0.1218 | 0.8295 | |
| TCGA | PEX6 | 5190 | RNAseq | -0.1129 | 0.3565 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PEX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PEX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PEX6 | 5190 | 7 | 0 | 23 | |
| GSE20123 | PEX6 | 5190 | 7 | 0 | 23 | |
| GSE43470 | PEX6 | 5190 | 6 | 0 | 37 | |
| GSE46452 | PEX6 | 5190 | 2 | 9 | 48 | |
| GSE47630 | PEX6 | 5190 | 8 | 4 | 28 | |
| GSE54993 | PEX6 | 5190 | 3 | 2 | 65 | |
| GSE54994 | PEX6 | 5190 | 11 | 6 | 36 | |
| GSE60625 | PEX6 | 5190 | 0 | 1 | 10 | |
| GSE74703 | PEX6 | 5190 | 6 | 0 | 30 | |
| GSE74704 | PEX6 | 5190 | 3 | 0 | 17 | |
| TCGA | PEX6 | 5190 | 20 | 13 | 63 |
Total number of gains: 73; Total number of losses: 35; Total Number of normals: 380.
Somatic mutations of PEX6:
Generating mutation plots.
Highly correlated genes for PEX6:
Showing top 20/38 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PEX6 | ZNF568 | 0.719031 | 3 | 0 | 3 |
| PEX6 | SLC22A7 | 0.698779 | 3 | 0 | 3 |
| PEX6 | GPR150 | 0.687902 | 3 | 0 | 3 |
| PEX6 | KRT35 | 0.682039 | 4 | 0 | 4 |
| PEX6 | FMR1NB | 0.653279 | 3 | 0 | 3 |
| PEX6 | ZNF81 | 0.650578 | 3 | 0 | 3 |
| PEX6 | FAAH2 | 0.650105 | 3 | 0 | 3 |
| PEX6 | CELF5 | 0.646938 | 3 | 0 | 3 |
| PEX6 | FCN3 | 0.646401 | 4 | 0 | 3 |
| PEX6 | ZC3H10 | 0.628016 | 4 | 0 | 3 |
| PEX6 | ZNF157 | 0.617875 | 4 | 0 | 3 |
| PEX6 | APCDD1 | 0.617795 | 3 | 0 | 3 |
| PEX6 | TAOK2 | 0.617025 | 3 | 0 | 3 |
| PEX6 | ADARB2 | 0.609285 | 4 | 0 | 3 |
| PEX6 | RABGGTB | 0.607998 | 4 | 0 | 3 |
| PEX6 | CDHR5 | 0.594534 | 4 | 0 | 3 |
| PEX6 | GCM2 | 0.592408 | 4 | 0 | 3 |
| PEX6 | CPLX2 | 0.586354 | 5 | 0 | 3 |
| PEX6 | SYT2 | 0.583989 | 5 | 0 | 3 |
| PEX6 | CLTCL1 | 0.583736 | 5 | 0 | 3 |
For details and further investigation, click here
