PFKFB4

 

Full name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 5210 HGNC ID: HGNC:8875 Ensembl Gene: ENSG00000114268 OMIM ID: 605320
Drug and gene relationship at DGIdb

 

PFKFB4 involved pathways:

KEGG pathway Description View
hsa04152AMPK signaling pathway

 

Expression of PFKFB4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PFKFB4 5210 228499_at 0.5982 0.5150
GSE20347 PFKFB4 5210 206246_at 0.0241 0.7487
GSE23400 PFKFB4 5210 206246_at 0.0527 0.2783
GSE26886 PFKFB4 5210 228499_at 0.2142 0.4281
GSE29001 PFKFB4 5210 206246_at 0.0233 0.8737
GSE38129 PFKFB4 5210 206246_at -0.0324 0.7013
GSE45670 PFKFB4 5210 228499_at 0.8216 0.0016
GSE53622 PFKFB4 5210 120406 0.5217 0.0097
GSE53624 PFKFB4 5210 16208 0.8660 0.0000
GSE63941 PFKFB4 5210 228499_at 0.0610 0.9141
GSE77861 PFKFB4 5210 206246_at -0.0063 0.9603
GSE97050 PFKFB4 5210 A_24_P362904 0.0636 0.8494
SRP007169 PFKFB4 5210 RNAseq 0.6690 0.3255
SRP008496 PFKFB4 5210 RNAseq 0.0447 0.9259
SRP064894 PFKFB4 5210 RNAseq 1.1009 0.0004
SRP133303 PFKFB4 5210 RNAseq 1.0676 0.0003
SRP159526 PFKFB4 5210 RNAseq 0.9456 0.0362
SRP193095 PFKFB4 5210 RNAseq 1.1403 0.0000
SRP219564 PFKFB4 5210 RNAseq -0.3348 0.6389
TCGA PFKFB4 5210 RNAseq 0.8410 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by PFKFB4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PFKFB4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PFKFB4 5210 0 18 12
GSE20123 PFKFB4 5210 0 19 11
GSE43470 PFKFB4 5210 0 19 24
GSE46452 PFKFB4 5210 3 16 40
GSE47630 PFKFB4 5210 1 24 15
GSE54993 PFKFB4 5210 6 2 62
GSE54994 PFKFB4 5210 0 36 17
GSE60625 PFKFB4 5210 5 0 6
GSE74703 PFKFB4 5210 0 15 21
GSE74704 PFKFB4 5210 0 12 8
TCGA PFKFB4 5210 0 78 18

Total number of gains: 15; Total number of losses: 239; Total Number of normals: 234.  

 

Somatic mutations of PFKFB4:

 

Generating mutation plots.

 

Highly correlated genes for PFKFB4:

 

Showing top 20/300 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PFKFB4MAGEB10.676965303
PFKFB4NKAIN40.670337303
PFKFB4SLC12A30.659692403
PFKFB4CNIH20.652496404
PFKFB4C20orf1410.651333303
PFKFB4USHBP10.639194303
PFKFB4PRX0.639071404
PFKFB4CC2D1B0.637707404
PFKFB4CDH30.634217303
PFKFB4MYBPC30.633395403
PFKFB4PYHIN10.633063303
PFKFB4SALL40.625263403
PFKFB4OR10H30.624946303
PFKFB4SERPINA60.624762303
PFKFB4RLN30.622876303
PFKFB4DNASE1L20.62261403
PFKFB4KHDRBS20.622019403
PFKFB4DLGAP30.621414404
PFKFB4JAKMIP10.620349303
PFKFB4FOLR30.618836504

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