| Full name: pyrin and HIN domain family member 1 | Alias Symbol: IFIX|MGC23885 | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 149628 | HGNC ID: HGNC:28894 | Ensembl Gene: ENSG00000163564 | OMIM ID: 612677 |
| Drug and gene relationship at DGIdb | |||
Expression of PYHIN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PYHIN1 | 149628 | 216748_at | -0.0765 | 0.8248 | |
| GSE20347 | PYHIN1 | 149628 | 216748_at | -0.0280 | 0.7913 | |
| GSE23400 | PYHIN1 | 149628 | 216748_at | -0.1571 | 0.0001 | |
| GSE26886 | PYHIN1 | 149628 | 216748_at | -0.3334 | 0.0017 | |
| GSE29001 | PYHIN1 | 149628 | 216748_at | -0.2489 | 0.1614 | |
| GSE38129 | PYHIN1 | 149628 | 216748_at | -0.2006 | 0.0095 | |
| GSE45670 | PYHIN1 | 149628 | 216748_at | 0.0839 | 0.5516 | |
| GSE53622 | PYHIN1 | 149628 | 15856 | 0.7585 | 0.0000 | |
| GSE53624 | PYHIN1 | 149628 | 15856 | 0.8498 | 0.0000 | |
| GSE63941 | PYHIN1 | 149628 | 216748_at | 0.2557 | 0.0742 | |
| GSE77861 | PYHIN1 | 149628 | 216748_at | -0.0671 | 0.6164 | |
| GSE97050 | PYHIN1 | 149628 | A_33_P3231407 | 0.9007 | 0.2014 | |
| SRP133303 | PYHIN1 | 149628 | RNAseq | -0.1205 | 0.6705 | |
| SRP193095 | PYHIN1 | 149628 | RNAseq | -0.0431 | 0.9015 | |
| SRP219564 | PYHIN1 | 149628 | RNAseq | 0.9755 | 0.0885 | |
| TCGA | PYHIN1 | 149628 | RNAseq | 0.5522 | 0.1741 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PYHIN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PYHIN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PYHIN1 | 149628 | 9 | 0 | 21 | |
| GSE20123 | PYHIN1 | 149628 | 9 | 0 | 21 | |
| GSE43470 | PYHIN1 | 149628 | 7 | 2 | 34 | |
| GSE46452 | PYHIN1 | 149628 | 2 | 1 | 56 | |
| GSE47630 | PYHIN1 | 149628 | 14 | 0 | 26 | |
| GSE54993 | PYHIN1 | 149628 | 0 | 5 | 65 | |
| GSE54994 | PYHIN1 | 149628 | 16 | 0 | 37 | |
| GSE60625 | PYHIN1 | 149628 | 0 | 0 | 11 | |
| GSE74703 | PYHIN1 | 149628 | 7 | 2 | 27 | |
| GSE74704 | PYHIN1 | 149628 | 3 | 0 | 17 | |
| TCGA | PYHIN1 | 149628 | 42 | 3 | 51 |
Total number of gains: 109; Total number of losses: 13; Total Number of normals: 366.
Somatic mutations of PYHIN1:
Generating mutation plots.
Highly correlated genes for PYHIN1:
Showing top 20/615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PYHIN1 | PBOV1 | 0.717543 | 4 | 0 | 4 |
| PYHIN1 | KHDRBS2 | 0.711027 | 4 | 0 | 4 |
| PYHIN1 | PIK3R6 | 0.707544 | 3 | 0 | 3 |
| PYHIN1 | IFNA7 | 0.707353 | 5 | 0 | 5 |
| PYHIN1 | HLA-DOA | 0.705194 | 7 | 0 | 6 |
| PYHIN1 | IFNA10 | 0.703837 | 5 | 0 | 5 |
| PYHIN1 | NME9 | 0.700408 | 3 | 0 | 3 |
| PYHIN1 | TNFSF8 | 0.697427 | 6 | 0 | 5 |
| PYHIN1 | UTF1 | 0.696631 | 3 | 0 | 3 |
| PYHIN1 | BLK | 0.688661 | 3 | 0 | 3 |
| PYHIN1 | JAK3 | 0.687758 | 7 | 0 | 7 |
| PYHIN1 | RNF17 | 0.686566 | 4 | 0 | 4 |
| PYHIN1 | P2RY8 | 0.680299 | 4 | 0 | 4 |
| PYHIN1 | SIT1 | 0.667784 | 8 | 0 | 7 |
| PYHIN1 | MS4A1 | 0.666925 | 6 | 0 | 5 |
| PYHIN1 | FXYD5 | 0.663055 | 4 | 0 | 3 |
| PYHIN1 | UMOD | 0.661914 | 6 | 0 | 6 |
| PYHIN1 | GJB4 | 0.661498 | 5 | 0 | 4 |
| PYHIN1 | HVCN1 | 0.66127 | 3 | 0 | 3 |
| PYHIN1 | SLC22A13 | 0.656904 | 4 | 0 | 4 |
For details and further investigation, click here
