CDH3

 

Full name: cadherin 3 Alias Symbol: CDHP|PCAD
Type: protein-coding gene Cytoband: 16q22.1
Entrez ID: 1001 HGNC ID: HGNC:1762 Ensembl Gene: ENSG00000062038 OMIM ID: 114021
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CDH3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDH3 1001 203256_at 2.3412 0.0309
GSE20347 CDH3 1001 203256_at 1.4797 0.0001
GSE23400 CDH3 1001 203256_at 1.8371 0.0000
GSE26886 CDH3 1001 203256_at 1.6506 0.0003
GSE29001 CDH3 1001 203256_at 1.4901 0.0016
GSE38129 CDH3 1001 203256_at 2.3476 0.0000
GSE45670 CDH3 1001 203256_at 2.8475 0.0000
GSE63941 CDH3 1001 203256_at 4.7308 0.0005
GSE77861 CDH3 1001 203256_at 1.6260 0.0312
GSE97050 CDH3 1001 A_23_P49155 1.9656 0.1356
SRP007169 CDH3 1001 RNAseq 1.9446 0.0000
SRP008496 CDH3 1001 RNAseq 1.7223 0.0000
SRP064894 CDH3 1001 RNAseq 2.2291 0.0000
SRP133303 CDH3 1001 RNAseq 2.4207 0.0000
SRP159526 CDH3 1001 RNAseq 1.4061 0.0003
SRP193095 CDH3 1001 RNAseq 2.3319 0.0000
SRP219564 CDH3 1001 RNAseq 1.4447 0.2033
TCGA CDH3 1001 RNAseq 1.4228 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by CDH3 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of CDH3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDH3 1001 9 1 20
GSE20123 CDH3 1001 9 1 20
GSE43470 CDH3 1001 1 9 33
GSE46452 CDH3 1001 38 1 20
GSE47630 CDH3 1001 11 8 21
GSE54993 CDH3 1001 2 4 64
GSE54994 CDH3 1001 8 10 35
GSE60625 CDH3 1001 4 0 7
GSE74703 CDH3 1001 1 6 29
GSE74704 CDH3 1001 5 0 15
TCGA CDH3 1001 31 12 53

Total number of gains: 119; Total number of losses: 52; Total Number of normals: 317.  

 

Somatic mutations of CDH3:

 

Generating mutation plots.

 

Highly correlated genes for CDH3:

 

Showing top 20/1471 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDH3LAMB30.80400311011
CDH3MYO1B0.7985810010
CDH3XPR10.791249505
CDH3NETO20.786735909
CDH3LAMC20.78611411011
CDH3FANCD20.777928404
CDH3PLAU0.77695810010
CDH3TPX20.76475610010
CDH3CDCA50.761753505
CDH3CKS1B0.75991210010
CDH3FSCN10.75745911011
CDH3UBE2C0.7509910010
CDH3WDR660.750109706
CDH3ITGB40.74697711010
CDH3AURKB0.74375310010
CDH3CKAP2L0.743201505
CDH3TEAD40.742985909
CDH3TPM30.742496404
CDH3SLC2A10.7404910010
CDH3ITGA60.73837411010

For details and further investigation, click here